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Itgb3
Gene Detail
 Symbol
Name
ID
Itgb3
integrin beta 3
MGI:96612
Synonyms CD61, platelet glycoprotein IIIa (GP3A)
Feature Type protein coding gene
Genetic Map
Chromosome 11
67.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:104608000-104670476 bp, + strand
From VEGA annotation of GRCm38

  62477 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55444  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb3

Human
homologs
Human Homolog ITGB3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
NCBI Gene ID 3690
neXtProt AC  NX_P05106
Human Synonyms  BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT
Human Chr (Location)  17q21.32; chr17:47253842-47312711 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human ITGB3
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations exhibit platelet defects, extended bleeding times, cutaneous and gastrointestinal bleeding, anemia, increased bone mass, hypocalcemia, reduced survival, and placental defects associated with some fetal loss.
 
Human Diseases Modeled Using Mouse Itgb3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Itgb3 interacts with 351 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (87 annotations)
Process activation of protein kinase activity, angiogenesis involved in wound healing, ...
Component alpha9-beta1 integrin-ADAM8 complex, apical plasma membrane, ...
Function cell adhesion molecule binding, extracellular matrix binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (55)    Tissues (11)    Images (30)
Theiler Stages: 12, 13, 17, 23, 28
Assay TypeResults
RNA in situ 49
RT-PCR 6
cDNA source data(42)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) Genomic(1) cDNA(43) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000003177 (Evidence)
Ensembl Gene ModelENSMUSG00000020689 (Evidence)
Entrez Gene16416 (Evidence)
UniGene87150
DFCITC1587496, TC1636564, TC1663335, TC1759073
DoTSDT.101351329, DT.110534038, DT.528847, DT.87024986, DT.99855687
NIA Mouse Gene IndexU043237
Consensus CDS ProjectCCDS25536.1
International Mouse Knockout Project StatusItgb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003177 VEGA Gene Model | MGI Sequence Detail 62477 C57BL/6J ±  kb
transcript OTTMUST00000006575 VEGA | MGI Sequence Detail 5784 Not Applicable 
polypeptide OTTMUSP00000003116 VEGA | MGI Sequence Detail 787 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(5) UniProt(3)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(441 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027068 Integrin beta-3 subunit
InterPro IPR015812 Integrin beta subunit
InterPro IPR014836 Integrin beta subunit, cytoplasmic domain
InterPro IPR002369 Integrin beta subunit, N-terminal
InterPro IPR012896 Integrin beta subunit, tail
InterPro IPR016201 Plexin-like fold
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000002042 integrin beta-3
References (Earliest) J:35481 Phillips DR, et al., GPIIb-IIIa: the responsive integrin. Cell. 1991 May 3;65(3):359-62
(Latest) J:208083 Guo L, et al., Allogeneic platelet transfusions prevent murine T-cell-mediated immune thrombocytopenia. Blood. 2014 Jan 16;123(3):422-7
All references(207)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11491

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory