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Itgb3 Gene Detail
Summary
  • Symbol
    Itgb3
  • Name
    integrin beta 3
  • Synonyms
    CD61, platelet glycoprotein IIIa (GP3A)
  • Feature Type
    protein coding gene
  • IDs
    MGI:96612
    NCBI Gene: 16416
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:104498826-104561302 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 67.84 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    440 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96612
protein coding gene Chr11:104498826-104561302 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019278
protein coding gene Chr11:107782741-107842337 (+)
A/J MGP_AJ_G0019246
protein coding gene Chr11:103189644-103246057 (+)
AKR/J MGP_AKRJ_G0019215
protein coding gene Chr11:106340976-106403347 (+)
BALB/cJ MGP_BALBcJ_G0019220
protein coding gene Chr11:103622931-103679097 (+)
C3H/HeJ MGP_C3HHeJ_G0019029
protein coding gene Chr11:106582049-106639495 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019670
protein coding gene Chr11:111108808-111169494 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017295
protein coding gene Chr11:100575543-100634036 (+)
CAST/EiJ MGP_CASTEiJ_G0018583
protein coding gene Chr11:107643915-107702628 (+)
CBA/J MGP_CBAJ_G0018998
protein coding gene Chr11:115719373-115775702 (+)
DBA/2J MGP_DBA2J_G0019110
protein coding gene Chr11:102674297-102735101 (+)
FVB/NJ MGP_FVBNJ_G0019101
protein coding gene Chr11:102217488-102274869 (+)
LP/J MGP_LPJ_G0019180
protein coding gene Chr11:108247919-108306016 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019131
protein coding gene Chr11:115023371-115083993 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019707
protein coding gene Chr11:106741248-106800805 (+)
PWK/PhJ MGP_PWKPhJ_G0018348
protein coding gene Chr11:103780853-103839029 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018138
protein coding gene Chr11:106532859-106590829 (+)
WSB/EiJ MGP_WSBEiJ_G0018633
protein coding gene Chr11:106753227-106809546 (+)



Homology
more
  • Human Ortholog
    ITGB3, integrin subunit beta 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGB3, integrin subunit beta 3
  • Synonyms
    BDPLT16, BDPLT2, BDPLT24, CD61, GP3A, GPIIIa, GT, GT2
  • Links
    NCBI Gene ID: 3690
    neXtProt AC: NX_P05106
    UniProt: P05106

  • Chr Location
    17q21.32; chr17:47253827-47313743 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with Itgb3 mouse models; 10 with human ITGB3 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    83 phenotypes from 7 alleles in 8 genetic backgrounds
    17 phenotypes from multigenic genotypes
    2 images
    162 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations exhibit platelet defects, extended bleeding times, cutaneous and gastrointestinal bleeding, anemia, increased bone mass, hypocalcemia, reduced survival, and placental defects associated with some fetal loss.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16416 NCBI Gene Model | MGI Sequence Detail 62477 C57BL/6J ±  kb
    transcript NM_016780 RefSeq | MGI Sequence Detail 5795 ZRU/MplStud  
    polypeptide O54890 UniProt | EBI | MGI Sequence Detail 787 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 1
      cDNA 44
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11491
    References
    more
    • Summaries
      All 351
      Developmental Gene Expression 36
      Diseases 2
      Gene Ontology 27
      Phenotypes 162
    • Earliest
      J:35481 Phillips DR, et al., GPIIb-IIIa: the responsive integrin. Cell. 1991 May 3;65(3):359-62
    • Latest
      J:341971 Jiang R, et al., Milk osteopontin promotes intestinal development by up-regulating the expression of integrin alphavbeta3 and CD44. FASEB J. 2023 Jun;37(6):e22988

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory