Itgb3
Gene Detail

Symbol Name ID

Itgb3 integrin beta 3 MGI:96612

Synonyms

CD61, platelet glycoprotein IIIa (GP3A)

Feature Type

protein coding gene

Genetic Map

Chromosome 11

67.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr11:104608000-104670476 bp, + strand From VEGA annotation of GRCm38   62477 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55444  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb3

Human homologs

Human Homolog		ITGB3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
NCBI Gene ID		3690
neXtProt AC		NX_P05106
Human Synonyms		BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT
Human Chr (Location)		17q21.32; chr17:45331208-45390077 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human ITGB3

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Homozygotes for targeted mutations exhibit platelet defects, extended bleeding times, cutaneous and gastrointestinal bleeding, anemia, increased bone mass, hypocalcemia, reduced survival, and placental defects associated with some fetal loss.

 
Human Diseases Modeled Using Mouse Itgb3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (46 annotations)

Process	activation of protein kinase activity, angiogenesis involved in wound healing, ...
Component	alpha9-beta1 integrin-ADAM8 complex, alpha9-beta1 integrin complex, ...
Function	cell adhesion molecule binding, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (55)    Tissues (11)    Images (30)
Theiler Stages: 12, 13, 17, 23, 28

Assay Type	Results
RNA in situ	49
RT-PCR	6

cDNA source data(41)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(47) Genomic(1) cDNA(42) Primer pair(4)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000003177 (Evidence)
Ensembl Gene Model	ENSMUSG00000020689 (Evidence)
Entrez Gene	16416 (Evidence)
UniGene	87150
DFCI	TC1587496, TC1636564, TC1663335, TC1759073
DoTS	DT.101351329, DT.110534038, DT.528847, DT.87024986, DT.99855687
NIA Mouse Gene Index	U043237
Consensus CDS Project	CCDS25536.1
International Mouse Knockout Project Status	Itgb3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003177	VEGA Gene Model | MGI Sequence Detail	62477	C57BL/6J
transcript	OTTMUST00000006575	VEGA | MGI Sequence Detail	5784	Not Applicable
polypeptide	OTTMUSP00000003116	VEGA | MGI Sequence Detail	787	Not Applicable

All sequences(36) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(247 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR027068	Integrin beta-3 subunit
InterPro	IPR015812	Integrin beta subunit
InterPro	IPR014836	Integrin beta subunit, cytoplasmic domain
InterPro	IPR002369	Integrin beta subunit, N-terminal
InterPro	IPR012896	Integrin beta subunit, tail
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000002042	integrin beta-3

References

(Earliest) J:35481 Phillips DR, et al., GPIIb-IIIa: the responsive integrin. Cell. 1991 May 3;65(3):359-62
(Latest) J:195883 An J, et al., Heparin rescues factor V Leiden-associated placental failure independent of anticoagulation in a murine high-risk pregnancy model. Blood. 2013 Mar 14;121(11):2127-34
All references(185)

Other accession IDs

MGD-MRK-11491