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Itgb3
Gene Detail
Symbol

Name
ID
Itgb3
integrin beta 3
MGI:96612
Synonyms
CD61, platelet glycoprotein IIIa (GP3A)
Feature Type
protein coding gene
Genetic Map
Chromosome 11
67.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:104608000-104670476 bp, + strand
From VEGA annotation of GRCm38

  62477 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55444  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ITGB3
Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb3

Human
homologs
ITGB3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3690
neXtProt AC: NX_P05106

Human Synonyms: BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT

Human Chr (Location): 17q21.32; chr17:47253842-47312711 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human ITGB3

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted mutations exhibit platelet defects, extended bleeding times, cutaneous and gastrointestinal bleeding, anemia, increased bone mass, hypocalcemia, reduced survival, and placental defects associated with some fetal loss.
 
Human Diseases Modeled in Mice Using Itgb3 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Itgb3 interacts with 351 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (28 records)
Data Summary: Results (55)    Tissues (11)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 49
RT-PCR 6
cDNA source data(42)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase itgb3 ; ZFIN itgb3a, itgb3b    NEW 
Molecular
reagents
All nucleic(48) Genomic(1) cDNA(43) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000003177 (Evidence)
Ensembl Gene Model ENSMUSG00000020689 (Evidence)
Entrez Gene 16416 (Evidence)
UniGene 87150
DFCI TC1587496, TC1636564, TC1663335, TC1759073
DoTS DT.101351329, DT.110534038, DT.528847, DT.87024986, DT.99855687
NIA Mouse Gene Index U043237
Consensus CDS Project CCDS25536.1
International Mouse Phenotyping Consortium Status Itgb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003177 VEGA Gene Model | MGI Sequence Detail 62477 C57BL/6J ±  kb
transcript OTTMUST00000006575 VEGA | MGI Sequence Detail 5784 Not Applicable 
polypeptide OTTMUSP00000003116 VEGA | MGI Sequence Detail 787 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(3)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(441 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027068 Integrin beta-3 subunit
InterPro IPR015812 Integrin beta subunit
InterPro IPR014836 Integrin beta subunit, cytoplasmic domain
InterPro IPR002369 Integrin beta subunit, N-terminal
InterPro IPR012896 Integrin beta subunit, tail
InterPro IPR016201 Plexin-like fold
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000002042 integrin beta-3
References
(Earliest) J:35481 Phillips DR, et al., GPIIb-IIIa: the responsive integrin. Cell. 1991 May 3;65(3):359-62
(Latest) J:219982 Carter RZ, et al., Tumour but not stromal expression of beta3 integrin is essential, and is required early, for spontaneous dissemination of bone-metastatic breast cancer. J Pathol. 2015 Apr;235(5):760-72
All references(211)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11491

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory