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Itgb3 Gene Detail
Summary
  • Symbol
    Itgb3
  • Name
    integrin beta 3
  • Synonyms
    CD61, platelet glycoprotein IIIa (GP3A)
  • Feature Type
    protein coding gene
  • IDs
    MGI:96612
    NCBI Gene: 16416
  • Gene Overview
    MyGene.info: ITGB3
Location & Maps
more
  • Sequence Map
    Chr11:104608000-104670476 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62477 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 67.84 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ITGB3, integrin subunit beta 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ITGB3, integrin subunit beta 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT
  • Links
    NCBI Gene ID: 3690
    neXtProt AC: NX_P05106

  • Chr Location
    17q21.32; chr17:47253842-47312711 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Itgb3 mouse models; 4 with human ITGB3 associations

Human Disease Mouse Models
       Bleeding Disorder, Platelet-Type, 16; BDPLT16   OMIM: 187800 View 1 model
Glanzmann Thrombasthenia; GT   OMIM: 273800 View 1 model
       Integrin, Beta-3; ITGB3   OMIM: 173470
Myocardial Infarction, Susceptibility to   OMIM: 608446
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    81 phenotypes from 7 alleles in 8 genetic backgrounds
    17 phenotypes from multigenic genotypes
    2 images
    110 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations exhibit platelet defects, extended bleeding times, cutaneous and gastrointestinal bleeding, anemia, increased bone mass, hypocalcemia, reduced survival, and placental defects associated with some fetal loss.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003177 VEGA Gene Model | MGI Sequence Detail 62477 C57BL/6J ±  kb
transcript OTTMUST00000006575 VEGA | MGI Sequence Detail 5784 Not Applicable  
polypeptide OTTMUSP00000003116 VEGA | MGI Sequence Detail 787 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    440 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 48
    Genomic 1
    cDNA 43
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-11491
References
more
  • Summaries
    All 228
    Developmental Gene Expression 29
    Diseases 2
    Gene Ontology 20
    Phenotypes 110
  • Earliest
    J:35481 Phillips DR, et al., GPIIb-IIIa: the responsive integrin. Cell. 1991 May 3;65(3):359-62
  • Latest
    J:232801 Misra A, et al., Integrin beta3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. J Exp Med. 2016 Mar 7;213(3):451-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory