Symbol
Name
ID

Itgb3
integrin beta 3
MGI:96612

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgA level	Increased circulating IgE level	Macroscopic hematuria
Disease(s) Associated with ITGB3	Increased circulating IgA level	Increased circulating IgE level	Macroscopic hematuria
Glanzmann's thrombasthenia
thrombocytopenia

Mouse Phenotypes

increased response of heart to induced stress

abnormal platelet physiology

abnormal platelet activation

decreased platelet aggregation

abnormal platelet dense granule physiology

decreased circulating calcium level

abnormal hemostasis

abnormal blood coagulation

abnormal thrombosis

decreased susceptibility to induced thrombosis

increased bleeding time

decreased collagen level

increased transforming growth factor beta level

enhanced wound healing

Availability

Mouse Genotype

Itgb3^tm1Aja/Itgb3^tm1Aja

Itgb3^tm1Drp/Itgb3^tm1Drp

Itgb3^tm1Hyn/Itgb3^tm1Hyn

Itgb3^tm1Mgin/Itgb3^tm1Mgin

Itgb3^tm2Mgin/Itgb3^tm2Mgin

Itgb3^tm1Hyn/Itgb3⁺

Itgb3^tm1Hyn/Itgb3^tm1.1Wlbcr
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Itgb3^tm1Hyn/Itgb3^tm1.1Wlbcr
Tg(Pf4-icre)Q3Rsko/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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