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Targeted Allele Detail
Symbol: Itgb3tm1Hyn
Name: integrin beta 3; targeted mutation 1, Richard Hynes
MGI ID: MGI:2175913
Synonyms: beta3-, Beta3, beta3 KO
Gene: Itgb3  Location: Chr11:104498826-104561302 bp, + strand  Genetic Position: Chr11, 67.84 cM
Alliance: Itgb3tm1Hyn page
Survival of Itgb3tm1Hyn/Itgb3tm1Hyn mice is compromised due to placental defects and hemorrhage

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:52262
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced 1.4 kb of sequence including exons I and II. FACS, immunoprecipitation, and immunofluorescence analyses did not detect protein expression in platelets and MEFs from homozygous mutant animals. (J:52262)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 18 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Itgb3tm1Hyn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Itgb3 Mutation:  33 strains or lines available
Original:  J:52262 Hodivala-Dilke KM, et al., Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest. 1999 Jan;103(2):229-38
All:  129 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory