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Insr
Gene Detail
 Symbol
Name
ID
Insr
insulin receptor
MGI:96575
Synonyms 4932439J01Rik, CD220, D630014A15Rik, IR, IR-A, IR-B
Feature Type protein coding gene
Genetic Map
Chromosome 8
1.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr8:3150922-3279617 bp, - strand
From VEGA annotation of GRCm38

  128696 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20090  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: insulin receptor
Gene Tree: Insr

Human
homologs
Human Homolog INSR, insulin receptor
NCBI Gene ID 3643
neXtProt AC  NX_P06213
Human Synonyms  CD220, HHF5
Human Chr (Location)  19p13.3-p13.2; chr19:7112255-7294328 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human INSR
Alleles
and
phenotypes
All alleles(10) : Chemically induced (ENU)(3) Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Null mutants grow slowly and die by 7 days of age with ketoacidosis, high serum insulin and triglycerides, low glycogen stores and fatty livers. Tissue specific knockouts show milder lipid metabolism anomalies. Point mutation heterozygotes exhibit hyperglycemia, hyperinsulinemia and glucosuria.
 
Human Diseases Modeled Using Mouse Insr (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (105 annotations)
Process activation of MAPK activity, activation of protein kinase activity, ...
Component caveola, cytosol, ...
Function 3-phosphoinositide-dependent protein kinase binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (26)    Tissues (15)    Images (7)
Theiler Stages: 2, 3, 5, 11, 13, 15, 21, 23, 26, 28
Assay TypeResults
RNA in situ 5
RT-PCR 21
cDNA source data(74)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(85) Genomic(5) cDNA(75) Primer pair(3) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000031438 (Evidence)
Ensembl Gene ModelENSMUSG00000005534 (Evidence)
Entrez Gene16337 (Evidence)
UniGene268003
DFCITC1598723, TC1618223, TC1731374
DoTSDT.101254833, DT.40156503
NIA Mouse Gene IndexU029533
EC2.7.10.1
PDB1LK2
Consensus CDS ProjectCCDS22059.1
International Mouse Knockout Project StatusInsr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031438 VEGA Gene Model | MGI Sequence Detail 128696 C57BL/6J ±  kb
transcript OTTMUST00000077897 VEGA | MGI Sequence Detail 9355 Not Applicable 
polypeptide OTTMUSP00000041297 VEGA | MGI Sequence Detail 1372 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(6)
Polymorphisms RFLP(2) : SNPs within 2kb(592 from dbSNP Build 137)    SNPs within 2kb including multiple locations(600)
Protein-related
information
ResourceIDDescription
InterPro IPR000494 EGF receptor, L domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR006211 Furin-like cysteine-rich domain
InterPro IPR006212 Furin-like repeat
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016246 Tyrosine-protein kinase, insulin-like receptor
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000009064 insulin receptor
References (Earliest) J:9626 Wang LM, et al., Chromosome assignment of mouse insulin, colony stimulating factor 1, and low-density lipoprotein receptors. Genomics. 1988 Aug;3(2):172-6
(Latest) J:209413 Lopez-Izquierdo A, et al., The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization. Am J Physiol Heart Circ Physiol. 2014 Mar 1;306(5):H747-54
All references(261)
Other
accession IDs
MGD-MRK-11417, MGI:2442502, MGI:2443766

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory