Insr
Gene Detail

Symbol Name ID

Insr insulin receptor MGI:96575

Synonyms

4932439J01Rik, CD220, D630014A15Rik, IR, IR-A, IR-B

Feature Type

protein coding gene

Genetic Map

Chromosome 8

1.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr8:3150922-3279617 bp, - strand From VEGA annotation of GRCm38   128696 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20090  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: insulin receptor
Gene Tree: Insr

Human homologs

Human Homolog		INSR, insulin receptor
NCBI Gene ID		3643
neXtProt AC		NX_P06213
Human Synonyms		CD220, HHF5
Human Chr (Location)		19p13.3-p13.2; chr19:7112266-7294011 (-)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human INSR

Alleles and phenotypes

All alleles(10) : Targeted(5) Gene trapped(2) Chemically induced(3)
 

Null mutants grow slowly and die by 7 days of age with ketoacidosis, high serum insulin and triglycerides, low glycogen stores and fatty livers. Tissue specific knockouts show milder lipid metabolism anomalies. Point mutation heterozygotes exhibit hyperglycemia, hyperinsulinemia and glucosuria.

 
Human Diseases Modeled Using Mouse Insr (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (102 annotations)

Process	activation of MAPK activity, activation of protein kinase activity, ...
Component	caveola, cytosol, ...
Function	3-phosphoinositide-dependent protein kinase binding, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (26)    Tissues (15)    Images (7)
Theiler Stages: 2, 3, 5, 11, 13, 15, 21, 23, 26, 28

Assay Type	Results
RNA in situ	5
RT-PCR	21

cDNA source data(74)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(85) Genomic(5) cDNA(75) Primer pair(3) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000031438 (Evidence)
Ensembl Gene Model	ENSMUSG00000005534 (Evidence)
Entrez Gene	16337 (Evidence)
UniGene	268003
DFCI	TC1598723, TC1618223, TC1731374
DoTS	DT.101254833, DT.40156503
NIA Mouse Gene Index	U029533
EC	2.7.10.1
PDB	1LK2
Consensus CDS Project	CCDS22059.1
International Mouse Knockout Project Status	Insr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031438	VEGA Gene Model | MGI Sequence Detail	128696	C57BL/6J
transcript	OTTMUST00000077897	VEGA | MGI Sequence Detail	9355	Not Applicable
polypeptide	OTTMUSP00000041297	VEGA | MGI Sequence Detail	1372	Not Applicable

All sequences(37) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(2) : SNPs(449 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000494	EGF receptor, L domain
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR006211	Furin-like cysteine-rich domain
InterPro	IPR006212	Furin-like repeat
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR009030	Insulin-like growth factor binding protein, N-terminal
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016246	Tyrosine-protein kinase, insulin-like receptor
InterPro	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology	PR:000009064	insulin receptor

References

(Earliest) J:9626 Wang LM, et al., Chromosome assignment of mouse insulin, colony stimulating factor 1, and low-density lipoprotein receptors. Genomics. 1988 Aug;3(2):172-6
(Latest) J:192831 Lin JC, et al., RBM4 promotes pancreas cell differentiation and insulin expression. Mol Cell Biol. 2013 Jan;33(2):319-27
All references(238)

Other accession IDs

MGD-MRK-11417, MGI:2442502, MGI:2443766