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Insr
Gene Detail
Symbol

Name
ID
Insr
insulin receptor
MGI:96575
Synonyms
4932439J01Rik, CD220, D630014A15Rik, IR, IR-A, IR-B
Feature Type
protein coding gene
Genetic Map
Chromosome 8
1.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr8:3150922-3279617 bp, - strand
From VEGA annotation of GRCm38

  128696 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20090  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: INSR
Protein SuperFamily: insulin receptor
Gene Tree: Insr

Human
homologs
INSR, insulin receptor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3643
neXtProt AC: NX_P06213

Human Synonyms: CD220, HHF5

Human Chr (Location): 19p13.3-p13.2; chr19:7112255-7294000 (-)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human INSR

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(3) Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Null mutants grow slowly and die by 7 days of age with ketoacidosis, high serum insulin and triglycerides, low glycogen stores and fatty livers. Tissue specific knockouts show milder lipid metabolism anomalies. Point mutation heterozygotes exhibit hyperglycemia, hyperinsulinemia and glucosuria.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Insr interacts with 434 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (105 annotations)
Process activation of MAPK activity, activation of protein kinase activity, ...
Component caveola, cytosol, ...
Function 3-phosphoinositide-dependent protein kinase binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (24)    Tissues (14)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
RT-PCR 19
cDNA source data(74)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA INSR ; Xenbase LOC100492718 ; ZFIN insra, insrb    NEW 
Molecular
reagents
All nucleic(85) Genomic(5) cDNA(75) Primer pair(3) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000031438 (Evidence)
Ensembl Gene Model ENSMUSG00000005534 (Evidence)
Entrez Gene 16337 (Evidence)
UniGene 268003
DFCI TC1598723, TC1618223, TC1731374
DoTS DT.101254833, DT.40156503
NIA Mouse Gene Index U029533
EC 2.7.10.1
PDB 1LK2
Consensus CDS Project CCDS22059.1
International Mouse Phenotyping Consortium Status Insr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031438 VEGA Gene Model | MGI Sequence Detail 128696 C57BL/6J ±  kb
transcript OTTMUST00000077897 VEGA | MGI Sequence Detail 9355 Not Applicable 
polypeptide OTTMUSP00000041297 VEGA | MGI Sequence Detail 1372 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(6)
Polymorphisms
RFLP(2) : SNPs within 2kb(592 from dbSNP Build 137)    SNPs within 2kb including multiple locations(600)
Protein-related
information
ResourceIDDescription
InterPro IPR000494 EGF receptor, L domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR006211 Furin-like cysteine-rich domain
InterPro IPR006212 Furin-like repeat
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016246 Tyrosine-protein kinase, insulin-like receptor
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000009064 insulin receptor
References
(Earliest) J:9626 Wang LM, et al., Chromosome assignment of mouse insulin, colony stimulating factor 1, and low-density lipoprotein receptors. Genomics. 1988 Aug;3(2):172-6
(Latest) J:219690 Kim DK, et al., PKB/Akt phosphorylation of ERRgamma contributes to insulin-mediated inhibition of hepatic gluconeogenesis. Diabetologia. 2014 Dec;57(12):2576-85
All references(267)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11417, MGI:2442502, MGI:2443766

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory