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Ighm
Gene Detail
 Symbol
Name
ID
Ighm
immunoglobulin heavy constant mu
MGI:96448
STS D12Mit8
Synonyms BCR, Igh6, Igh-M, IgM, Ig mu, muH, muMT
Feature Type gene segment
Genetic Map
Chromosome 12
62.10 cM, cytoband F1-2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr12:113418950-113422730 bp, - strand
From Ensembl annotation of GRCm38

  3781 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: immunoglobulin V region
Gene Tree: Ighm
Alleles
and
phenotypes
All alleles(16) : Targeted(16)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology.
 
Human Diseases Modeled Using Mouse Ighm (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process activation of MAPK activity, antigen processing and presentation, ...
Component B cell receptor complex, external side of plasma membrane, ...
Function antigen binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (31)    Tissues (11)   
Theiler Stages: 16, 21, 22, 24, 25, 26, 28
Assay TypeResults
Northern blot 22
Western blot 9
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(105) Genomic(36) cDNA(64) Primer pair(3) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000076617 (Evidence)
Entrez Gene16019 (Evidence)
PDB1I8M, 4JVU, 4JVW, 4BA8
International Mouse Knockout Project StatusIghm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000076617 Ensembl Gene Model | MGI Sequence Detail 3781 C57BL/6J ±  kb
transcript ENSMUST00000177715 Ensembl | MGI Sequence Detail 1424 Not Applicable 
polypeptide ENSMUSP00000136807 Ensembl | MGI Sequence Detail 475 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(1) UniProt(10)
Polymorphisms All PCR and RFLP(8) : PCR(2) RFLP(6) SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR003596 Immunoglobulin V-set, subgroup
References (Earliest) J:5763 Warner NL, et al., Allotypes of mouse IgM immunoglobulin. Nature. 1977 Feb 3;265(5593):447-9
(Latest) J:210245 Huang W, et al., Dendritic cell-MHC class II and Itk regulate functional development of regulatory innate memory CD4+ T cells in bone marrow transplantation. J Immunol. 2014 Apr 1;192(7):3435-41
All references(698)
Other
accession IDs
MGD-MRK-11245, MGD-MRK-11260, MGI:2144796

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory