Ighm
Gene Detail

Symbol Name ID

Ighm immunoglobulin heavy constant mu MGI:96448

STS

D12Mit8

Synonyms

BCR, Igh6, Igh-M, IgM, Ig mu, muH, muMT

Feature Type

gene segment

Genetic Map

Chromosome 12

62.10 cM, cytoband F1-2
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr12:113418950-113422730 bp, - strand From Ensembl annotation of GRCm38   3781 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human    (Mammalian Orthology)
Comparative Map (Mouse/Human Ighm ± 2 cM)

Protein SuperFamily: immunoglobulin V region
Gene Tree: Ighm

Human ortholog

IGHM immunoglobulin heavy constant mu NCBI Gene ID 3507
Human Synonyms: AGM1, MU, VH
Human Chr14:106318037-106322322 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human IGHM (1)

Alleles and phenotypes

All alleles(16) : Targeted(16)
 

Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology.

 
Human Diseases Modeled Using Mouse Ighm (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	activation of MAPK activity, antigen processing and presentation, ...
Component	B cell receptor complex, external side of plasma membrane, ...
Function	antigen binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (31)    Tissues (11)   
Theiler Stages: 16, 21, 22, 24, 25, 26, 28

Assay Type	Results
Northern blot	22
Western blot	9

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(105) Genomic(36) cDNA(64) Primer pair(3) Other(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000076617 (Evidence)
Entrez Gene	16019 (Evidence)
PDB	1I8M
International Mouse Knockout Project Status	Ighm

Sequences

Length	Strain/Species
genomic	ENSMUSG00000076617	Ensembl Gene Model | MGI Sequence Detail	3781	C57BL/6J
transcript	ENSMUST00000177715	Ensembl | MGI Sequence Detail	1424	Not Applicable
polypeptide	ENSMUSP00000136807	Ensembl | MGI Sequence Detail	475	Not Applicable

All sequences(89) RefSeq(1) UniProt(11)

Polymorphisms

All PCR and RFLP(8) : PCR(2) RFLP(6) SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003597	Immunoglobulin C1-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site
InterPro	IPR013106	Immunoglobulin V-set
InterPro	IPR003596	Immunoglobulin V-set, subgroup

References

(Earliest) J:5763 Warner NL, et al., Allotypes of mouse IgM immunoglobulin. Nature. 1977 Feb 3;265(5593):447-9
(Latest) J:194127 He Y, et al., Tissue damage-associated "danger signals" influence T-cell responses that promote the progression of preneoplasia to cancer. Cancer Res. 2013 Jan 15;73(2):629-39
All references(636)

Other accession IDs

MGD-MRK-11245, MGD-MRK-11260, MGI:2144796