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Ighm
Gene Detail
Symbol

Name
ID
Ighm
immunoglobulin heavy constant mu
MGI:96448
STS
Synonyms
BCR, Igh6, Igh-M, IgM, Ig mu, muH, muMT
Feature Type
gene segment
Genetic Map
Chromosome 12
62.10 cM, cytoband F1-2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr12:113418950-113422730 bp, - strand
From Ensembl annotation of GRCm38

  3781 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: immunoglobulin V region
Gene Tree: Ighm
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Targeted(16)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology.
 
Human Diseases Modeled Using Mouse Ighm (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process activation of MAPK activity, antigen processing and presentation, ...
Component B cell receptor complex, external side of plasma membrane, ...
Function antigen binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (31)    Tissues (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 22
Western blot 9
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(105) Genomic(36) cDNA(64) Primer pair(3) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000076617 (Evidence)
Entrez Gene16019 (Evidence)
PDB1I8M, 4JVU, 4JVW, 4BA8
International Mouse Knockout Project StatusIghm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000076617 Ensembl Gene Model | MGI Sequence Detail 3781 C57BL/6J ±  kb
transcript ENSMUST00000177715 Ensembl | MGI Sequence Detail 1424 Not Applicable 
polypeptide ENSMUSP00000136807 Ensembl | MGI Sequence Detail 475 Not Applicable 

For the selected sequences
All sequences(99) RefSeq(1) UniProt(21)
Polymorphisms
All PCR and RFLP(8) : PCR(2) RFLP(6) SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR003596 Immunoglobulin V-set, subgroup
References
(Earliest) J:5763 Warner NL, et al., Allotypes of mouse IgM immunoglobulin. Nature. 1977 Feb 3;265(5593):447-9
(Latest) J:213739 Weber GF, et al., Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis. J Exp Med. 2014 Jun 2;211(6):1243-56
All references(707)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11245, MGD-MRK-11260, MGI:2144796

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory