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Ighm
Gene Detail
Symbol

Name
ID
Ighm
immunoglobulin heavy constant mu
MGI:96448
STS
Synonyms
BCR, Igh6, Igh-M, IgM, Ig mu, muH, muMT
Feature Type
gene segment
Genetic Map
Chromosome 12
62.10 cM, cytoband F1-2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr12:113418558-113422730 bp, - strand
From VEGA annotation of GRCm38

  4173 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: immunoglobulin V region
Gene Tree: Ighm
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Targeted(16) Transgenic(5)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology.
 
Human Diseases Modeled in Mice Using Ighm (1)    Mutations Annotated to Human Diseases (4)   
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process activation of MAPK activity, antigen processing and presentation, ...
Component B cell receptor complex, external side of plasma membrane, ...
Function antigen binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (31)    Tissues (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 22
Western blot 9
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ighm    NEW 
Molecular
reagents
All nucleic(105) Genomic(36) cDNA(64) Primer pair(3) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000051485 (Evidence)
Ensembl Gene Model ENSMUSG00000076617 (Evidence)
Entrez Gene 16019 (Evidence)
PDB 1I8M, 4BA8, 4JVU, 4JVW
International Mouse Phenotyping Consortium Status Ighm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051485 VEGA Gene Model | MGI Sequence Detail 4173 C57BL/6J ±  kb
transcript OTTMUST00000130088 VEGA | MGI Sequence Detail 1698 Not Applicable 
polypeptide OTTMUSP00000069791 VEGA | MGI Sequence Detail 476 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(1) UniProt(12)
Polymorphisms
All PCR and RFLP(8) : PCR(2) RFLP(6) SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR013106 Immunoglobulin V-set
References
(Earliest) J:5763 Warner NL, et al., Allotypes of mouse IgM immunoglobulin. Nature. 1977 Feb 3;265(5593):447-9
(Latest) J:222302 Zhu M, et al., B cells promote obesity-associated periodontitis and oral pathogen-associated inflammation. J Leukoc Biol. 2014 Aug;96(2):349-57
All references(717)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-11245, MGD-MRK-11260, MGI:2144796

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory