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Ighm Gene Detail
Summary
  • Symbol
    Ighm
  • Name
    immunoglobulin heavy constant mu
  • Synonyms
    BCR, Igh6, Igh-M, IgM, Ig mu, muH, muMT
  • Feature Type
    gene segment
  • IDs
    MGI:96448
    NCBI Gene: 16019
Location & Maps
more
  • Sequence Map
    Chr12:113418558-113422730 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4173 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 62.10 cM, cytoband F1-2
  • Mapping Data
    5 experiments
  • Sequence Tag
Homology
less
Human Diseases
more
  • Diseases
    2 with Ighm mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100 View 5 models
Lymphoma, Non-Hodgkin, Familial   OMIM: 605027 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    104 phenotypes from 14 alleles in 20 genetic backgrounds
    53 phenotypes from multigenic genotypes
    646 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    35
  • Targeted
    16
  • Transgenic
    19
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051485 VEGA Gene Model | MGI Sequence Detail 4173 C57BL/6J ±  kb
transcript OTTMUST00000130088 VEGA | MGI Sequence Detail 1698 Not Applicable  
polypeptide OTTMUSP00000069791 VEGA | MGI Sequence Detail 476 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    60 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 105
    Genomic 36
    cDNA 64
    Primer pair 3
    Other 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-11245, MGD-MRK-11260, MGI:2144796
References
more
  • Summaries
    All 726
    Developmental Gene Expression 5
    Diseases 7
    Gene Ontology 34
    Phenotypes 646
  • Earliest
    J:5763 Warner NL, et al., Allotypes of mouse IgM immunoglobulin. Nature. 1977 Feb 3;265(5593):447-9
  • Latest
    J:231111 Gu X, et al., AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma. Blood. 2016 Jan 7;127(1):102-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory