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Phenotypes Associated with This Genotype
Genotype
MGI:3623593
Allelic
Composition		 Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V281)3Jwt/0
Genetic
Background		 NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (18 available); any Ighm mutation (57 available)
Tg(Igh-6/Igh-V281)3Jwt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:91865 )
• the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

immune system
insulitis ( J:91865 )
• the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:91865

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory