Tg(Igh-VB1-8/Igh-6m)1Mjsk
Transgene Detail

Summary

• Symbol: Tg(Igh-VB1-8/Igh-6m)1Mjsk
• Name: transgene insertion 1, Mark J Shlomchik
• MGI ID: MGI:3578639
• Synonyms: mIg, Tg(Igh-VB1-8/Igh-6)1Mjsk
• Transgene: Tg(Igh-VB1-8/Igh-6m)1Mjsk Location: unknown
• Alliance: Tg(Igh-VB1-8/Igh-6m)1Mjsk page

Transgene origin

• Strain of Origin: NOD/Caj

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-VB1-8/Igh-6m)1Mjsk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ighm (MGI:96448)

• Mutation details: The transgene encodes a membrane-bound, but not a secreted, immunoglobulin mu heavy chain. The variable region of the transgene comprises the VDJ moiety from the functionally rearranged Igh gene of the C57BL/6-derived B1-8 hybridoma, containing the V-region segment Vh186.2 and recognizing the hapten (4-hydroxy-3-nitrophenyl)acetyl. This is followed by a J-C intron fragment containing the Igh intronic enhancer and an Igh-6 constant region gene (of haplotype a) from which the exon encoding the secreted form of Igmu and its associated polyadenylation signal have been deleted. (J:55066)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:55066 Chan OT, et al., A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med. 1999 May 17;189(10):1639-48
• All: 16 reference(s)