Phenotypes Associated with This Genotype

Genotype
MGI:3623591

• Allelic Composition: Tg(Igh-6/Igh-V281)3Jwt/0
• Genetic Background: NOD.B6-Tg(Igh-6/Igh-V281)3Jwt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

insulitis ( J:91865 )

• by 40 weeks, pancreata of transgenic mice show extensive infiltrates

immune system

insulitis ( J:91865 )

• by 40 weeks, pancreata of transgenic mice show extensive infiltrates

decreased susceptibility to autoimmune diabetes ( J:91865 )

• transgenic mice are protected from developing diabetes; 16% develop diabetes by 40 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:91865