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Igf1r Gene Detail
Summary
  • Symbol
    Igf1r
  • Name
    insulin-like growth factor I receptor
  • Synonyms
    A330103N21Rik, CD221, hyft, IGF-1R, line 186
  • Feature Type
    protein coding gene
  • IDs
    MGI:96433
    NCBI Gene: 16001
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:67952827-68233668 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      280842 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 37.27 cM
  • Mapping Data
    23 experiments
Homology
more
  • Human Ortholog
    IGF1R, insulin like growth factor 1 receptor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IGF1R, insulin like growth factor 1 receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD221, IGFIR, IGFR, JTK13
  • Links
    NCBI Gene ID: 3480
    neXtProt AC: NX_P08069
    UniProt: P08069

  • Chr Location
    15q26.3; chr15:98648539-98964530 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    90 phenotypes from 8 alleles in 16 genetic backgrounds
    87 phenotypes from multigenic genotypes
    179 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted null mutants die at birth of respiratory failure; fetuses exhibit retarded growth, organ hypoplasia, ossification delay and nervous system and epidermal abnormalities. hyft homozygous fetuses are growth retarded and exhibit hydrops fetalis and focal hepatic ischemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000059602 VEGA Gene Model | MGI Sequence Detail 280842 C57BL/6J ±  kb
    transcript OTTMUST00000146160 VEGA | MGI Sequence Detail 11409 Not Applicable  
    polypeptide OTTMUSP00000076144 VEGA | MGI Sequence Detail 1369 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2105 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
    • InterPro Domains
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR006211 Furin-like cysteine-rich domain
      IPR006212 Furin-like repeat
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR000494 Receptor L-domain
      IPR036941 Receptor L-domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR016246 Tyrosine-protein kinase, insulin-like receptor
      IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
    Molecular
    Reagents
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    • All nucleic 158
      Genomic 1
      cDNA 147
      Primer pair 9
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-11229, MGI:1925023, MGI:3576016
    References
    more
    • Summaries
      All 384
      Developmental Gene Expression 77
      Diseases 3
      Gene Ontology 22
      Phenotypes 179
    • Earliest
      J:9941 Sundaresan S, et al., Insulin-like growth factor I receptor gene is concordant with c-Fes protooncogene and mouse chromosome 7 in somatic cell hybrids. Somat Cell Mol Genet. 1989 Jul;15(4):373-6
    • Latest
      J:260695 Tham YK, et al., Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies. Biochim Biophys Acta. 2018 Mar;1863(3):219-234

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory