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Igf1r
Gene Detail
Symbol

Name
ID
Igf1r
insulin-like growth factor I receptor
MGI:96433
Synonyms
A330103N21Rik, CD221, hyft, IGF-1R, line 186
Feature Type
protein coding gene
Genetic Map
Chromosome 7
37.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr7:67952859-68226780 bp, + strand
From Ensembl annotation of GRCm38

  273922 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30997  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: IGF1R
Protein SuperFamily: insulin receptor
Gene Tree: Igf1r

Human
homologs
IGF1R, insulin-like growth factor 1 receptor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3480
neXtProt AC: NX_P08069

Human Synonyms: CD221, IGFIR, IGFR, JTK13

Human Chr (Location): 15q26.3; chr15:98648539-98964530 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IGF1R

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Chemically induced (ENU)(1) Gene trapped(5) Targeted(12) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Targeted null mutants die at birth of respiratory failure; fetuses exhibit retarded growth, organ hypoplasia, ossification delay and nervous system and epidermal abnormalities. hyft homozygous fetuses are growth retarded and exhibit hydrops fetalis and focal hepatic ischemia.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Igf1r interacts with 249 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process axonogenesis, brain development, ...
Component caveola, integral component of membrane, ...
Function ATP binding, G-protein alpha-subunit binding, ...
External Resources: FuncBase
Expression
Literature Summary: (64 records)
Data Summary: Results (101)    Tissues (78)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 9
Western blot 4
RT-PCR 88
cDNA source data(140)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA IGF1R ; Xenbase igf1r ; ZFIN igf1ra, igf1rb    NEW 
Molecular
reagents
All nucleic(156) Genomic(1) cDNA(146) Primer pair(9)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000005533 (Evidence)
Entrez Gene 16001 (Evidence)
UniGene 275742
DFCI TC1597440, TC1607386, TC1642122, TC1659659
DoTS DT.101358881, DT.101366098, DT.103570546, DT.111015518, DT.40148770, DT.91332556, DT.94132199, DT.94199147, DT.97357994
NIA Mouse Gene Index U008198
EC 2.7.10.1
Consensus CDS Project CCDS21355.1
International Mouse Phenotyping Consortium Status Igf1r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005533 Ensembl Gene Model | MGI Sequence Detail 273922 C57BL/6J ±  kb
transcript ENSMUST00000005671 Ensembl | MGI Sequence Detail 4489 Not Applicable 
polypeptide ENSMUSP00000005671 Ensembl | MGI Sequence Detail 1369 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(12) UniProt(4)
Polymorphisms
RFLP(5) : SNPs within 2kb(2102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000494 EGF receptor, L domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR006211 Furin-like cysteine-rich domain
InterPro IPR006212 Furin-like repeat
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016246 Tyrosine-protein kinase, insulin-like receptor
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000003273 insulin-like growth factor 1 receptor
References
(Earliest) J:9941 Sundaresan S, et al., Insulin-like growth factor I receptor gene is concordant with c-Fes protooncogene and mouse chromosome 7 in somatic cell hybrids. Somat Cell Mol Genet. 1989 Jul;15(4):373-6
(Latest) J:220453 Shi Y, et al., Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4678-83
All references(258)
Other
accession IDs
MGD-MRK-11229, MGI:1925023, MGI:3576016

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory