Igf1r
Gene Detail

Symbol Name ID

Igf1r insulin-like growth factor I receptor MGI:96433

Synonyms

A330103N21Rik, CD221, hyft, IGF-1R, line 186

Feature Type

protein coding gene

Genetic Map

Chromosome 7

37.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)

Sequence Map

Chr7:67952859-68226780 bp, + strand From Ensembl annotation of GRCm38   273922 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:30997  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: insulin receptor
Gene Tree: Igf1r

Human homologs

Human Homolog		IGF1R, insulin-like growth factor 1 receptor
NCBI Gene ID		3480
neXtProt AC		NX_P08069
Human Synonyms		CD221, IGFIR, IGFR, JTK13
Human Chr (Location)		15q26.3; chr15:99192761-99507759 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human IGF1R

Alleles and phenotypes

All alleles(17) : Targeted(11) Gene trapped(5) Chemically induced(1)
 

Targeted null mutants die at birth of respiratory failure; fetuses exhibit retarded growth, organ hypoplasia, ossification delay and nervous system and epidermal abnormalities. hyft homozygous fetuses are growth retarded and exhibit hydrops fetalis and focal hepatic ischemia.

 

Gene Ontology (GO) classifications

All GO classifications: (64 annotations)

Process	axonogenesis, brain development, ...
Component	caveola, integral to membrane, ...
Function	ATP binding, G-protein alpha-subunit binding, ...

External Resources: FuncBase

Expression

Literature Summary: (55 records)
Data Summary: Results (107)    Tissues (83)    Images (6)
Theiler Stages: 2, 3, 4, 5, 11, 13, 15, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Northern blot	9
Western blot	4
RT-PCR	94

cDNA source data(139)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(154) Genomic(1) cDNA(145) Primer pair(8)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000005533 (Evidence)
Entrez Gene	16001 (Evidence)
UniGene	275742
DFCI	TC1597440, TC1607386, TC1642122, TC1659659
DoTS	DT.101358881, DT.101366098, DT.103570546, DT.111015518, DT.40148770, DT.91332556, DT.94132199, DT.94199147, DT.97357994
NIA Mouse Gene Index	U008198
EC	2.7.10.1
Consensus CDS Project	CCDS21355.1
International Mouse Knockout Project Status	Igf1r

Sequences

Length	Strain/Species
genomic	ENSMUSG00000005533	Ensembl Gene Model | MGI Sequence Detail	273922	C57BL/6J
transcript	ENSMUST00000005671	Ensembl | MGI Sequence Detail	4489	Not Applicable
polypeptide	ENSMUSP00000005671	Ensembl | MGI Sequence Detail	1369	Not Applicable

All sequences(53) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(5) : SNPs(1266 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000494	EGF receptor, L domain
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR006211	Furin-like cysteine-rich domain
InterPro	IPR006212	Furin-like repeat
InterPro	IPR009030	Growth factor, receptor
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016246	Tyrosine-protein kinase, insulin-like receptor
InterPro	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology	PR:000003273	insulin-like growth factor 1 receptor

References

(Earliest) J:9941 Sundaresan S, et al., Insulin-like growth factor I receptor gene is concordant with c-Fes protooncogene and mouse chromosome 7 in somatic cell hybrids. Somat Cell Mol Genet. 1989 Jul;15(4):373-6
(Latest) J:190464 Keniry A, et al., The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r. Nat Cell Biol. 2012 Jul;14(7):659-65
All references(227)

Other accession IDs

MGD-MRK-11229, MGI:1925023, MGI:3576016