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Igf1r
Gene Detail
Symbol

Name
ID
Igf1r
insulin-like growth factor I receptor
MGI:96433
Synonyms
A330103N21Rik, CD221, hyft, IGF-1R, line 186
Feature Type
protein coding gene
Genetic Map
Chromosome 7
37.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr7:67952859-68226780 bp, + strand
From Ensembl annotation of GRCm38

  273922 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30997  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: insulin receptor
Gene Tree: Igf1r

Human
homologs
Human Homolog IGF1R, insulin-like growth factor 1 receptor
NCBI Gene ID 3480
neXtProt AC  NX_P08069
Human Synonyms  CD221, IGFIR, IGFR, JTK13
Human Chr (Location)  15q26.3; chr15:98649047-98964530 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human IGF1R
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(1) Gene trapped(5) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted null mutants die at birth of respiratory failure; fetuses exhibit retarded growth, organ hypoplasia, ossification delay and nervous system and epidermal abnormalities. hyft homozygous fetuses are growth retarded and exhibit hydrops fetalis and focal hepatic ischemia.
 
Interactions
Igf1r interacts with 249 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process axonogenesis, brain development, ...
Component caveola, integral component of membrane, ...
Function ATP binding, G-protein alpha-subunit binding, ...
External Resources: FuncBase
Expression
Literature Summary: (64 records)
Data Summary: Results (101)    Tissues (78)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 9
Western blot 4
RT-PCR 88
cDNA source data(140)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(156) Genomic(1) cDNA(146) Primer pair(9)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000005533 (Evidence)
Entrez Gene16001 (Evidence)
UniGene275742
DFCITC1597440, TC1607386, TC1642122, TC1659659
DoTSDT.101358881, DT.101366098, DT.103570546, DT.111015518, DT.40148770, DT.91332556, DT.94132199, DT.94199147, DT.97357994
NIA Mouse Gene IndexU008198
EC2.7.10.1
Consensus CDS ProjectCCDS21355.1
International Mouse Knockout Project StatusIgf1r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005533 Ensembl Gene Model | MGI Sequence Detail 273922 C57BL/6J ±  kb
transcript ENSMUST00000005671 Ensembl | MGI Sequence Detail 4489 Not Applicable 
polypeptide ENSMUSP00000005671 Ensembl | MGI Sequence Detail 1369 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(12) UniProt(7)
Polymorphisms
RFLP(5) : SNPs within 2kb(2102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000494 EGF receptor, L domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR006211 Furin-like cysteine-rich domain
InterPro IPR006212 Furin-like repeat
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016246 Tyrosine-protein kinase, insulin-like receptor
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000003273 insulin-like growth factor 1 receptor
References
(Earliest) J:9941 Sundaresan S, et al., Insulin-like growth factor I receptor gene is concordant with c-Fes protooncogene and mouse chromosome 7 in somatic cell hybrids. Somat Cell Mol Genet. 1989 Jul;15(4):373-6
(Latest) J:214883 Xu J, et al., Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation. Aging Cell. 2014 Feb;13(1):19-28
All references(254)
Other
accession IDs
MGD-MRK-11229, MGI:1925023, MGI:3576016

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory