Symbol
Name
ID

Igf1r
insulin-like growth factor I receptor
MGI:96433

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Increased circulating ferritin concentration	Elevated circulating hepatic transaminase concentration	Increased circulating lactate dehydrogenase concentration	Diabetes mellitus	Fever	Hematuria	Elevated urinary homovanillic acid	Elevated urinary vanillylmandelic acid	Proteinuria	Elevated urinary catecholamine level	Elevated circulating catecholamine level
Disease(s) Associated with IGF1R	Increased circulating ferritin concentration	Elevated circulating hepatic transaminase concentration	Increased circulating lactate dehydrogenase concentration	Diabetes mellitus	Fever	Hematuria	Elevated urinary homovanillic acid	Elevated urinary vanillylmandelic acid	Proteinuria	Elevated urinary catecholamine level	Elevated circulating catecholamine level
IgA glomerulonephritis
neuroblastoma
pancreatic cancer

Mouse Phenotypes

homeostasis/metabolism phenotype

abnormal vascular wound healing

increased circulating glucose level

hyperglycemia

cyanosis

hydrops fetalis

abnormal glucose homeostasis

impaired glucose tolerance

increased insulin sensitivity

decreased adiponectin level

decreased collagen level

abnormal response to injury

abnormal susceptibility to injury induced morbidity/mortality

decreased susceptibility to injury

Availability

Mouse Genotype

Igf1r^hyft/Igf1r^hyft

Igf1r^tm1Arge/Igf1r^tm1Arge

Igf1r^tm1Mhz/Igf1r^tm1Mhz

Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz
Tg(Ckmm-cre)5Khn/0 (conditional)

Igf1r^tm1.1Mhz/Igf1r^tm1.1Mhz
Tg(Ins2-cre)25Mgn/0 (conditional)

Igf1r^tm1Jcbr/Igf1r^tm1Jcbr
Tg(Fabp4-cre)1Abel/? (conditional)

Igf1r^tm1Jcbr/Igf1r^tm1Jcbr
Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 (conditional)

Igf1r^tm1Jcbr/Igf1r^tm1Jcbr
Tg(Nkx2-1-cre)2Sand/0 (conditional)

Igf1r^tm1Jcbr/Igf1r^tm1Jcbr
Tg(Scgb1a1-cre)1Tauc/0 (conditional)

Igf1r^tm2Arge/Igf1r⁺
Tg(Tek-cre)1Ywa/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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