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Hoxd9 Gene Detail
Summary
  • Symbol
    Hoxd9
  • Name
    homeobox D9
  • Synonyms
    Hox-4.4, Hox-5.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96210
    NCBI Gene: 15438
  • Member of
    Hoxd cluster
  • Gene Overview
    MyGene.info: HOXD9
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:74697727-74700208 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2482 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 44.13 cM
  • Mapping Data
    13 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    HOXD9, homeobox D9
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HOXD9, homeobox D9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX4, Hox-4.3, HOX4C, Hox-5.2
  • Links
    NCBI Gene ID: 3235
    neXtProt AC: NX_P28356
    UniProt: P28356

  • Chr Location
    2q31.1; chr2:176122685-176124917 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    48 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation exhibit anterior transformation of lumbar, sacral, and caudal vertebrae with abnormal humerus morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016552 VEGA Gene Model | MGI Sequence Detail 2482 C57BL/6J ±  kb
    transcript OTTMUST00000040004 VEGA | MGI Sequence Detail 2136 Not Applicable  
    polypeptide OTTMUSP00000017844 VEGA | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      3 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 15
      cDNA 21
      Primer pair 10
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10851, MGD-MRK-10859, MGD-MRK-10911
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 65
      Gene Ontology 10
      Phenotypes 47
    • Earliest
      J:9875 Oliver G, et al., Complementary homeo protein gradients in developing limb buds. Genes Dev. 1989 May;3(5):641-50
    • Latest
      J:259687 Zakany J, et al., Rescue of an aggressive female sexual courtship in mice by CRISPR/Cas9 secondary mutation in vivo. BMC Res Notes. 2018 Mar 27;11(1):193

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory