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Hmox1 Gene Detail
Summary
  • Symbol
    Hmox1
  • Name
    heme oxygenase 1
  • Synonyms
    D8Wsu38e, heme oxygenase 1, Hmox, HO1, HO-1, Hsp32
  • Feature Type
    protein coding gene
  • IDs
    MGI:96163
    NCBI Gene: 15368
  • Gene Overview
    MyGene.info: HMOX1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:75093621-75100589 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6969 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 35.59 cM, cytoband C1
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    HMOX1, heme oxygenase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HMOX1, heme oxygenase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bK286B10, HMOX1D, HO-1, HSP32
  • Links
    NCBI Gene ID: 3162
    neXtProt AC: NX_P09601
    UniProt: P09601

  • Chr Location
    22q12.3; chr22:35381067-35394214 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Hmox1 mouse models; 1 with human HMOX1 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    88 phenotypes from 6 alleles in 10 genetic backgrounds
    38 phenotypes from multigenic genotypes
    5 images
    103 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit low serum iron levels, increased hepatic and renal iron, oxidative damage, tissue injury, chronic inflammation, reduced neuronal proliferation, and increased sensitivity to hypoxia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030644 VEGA Gene Model | MGI Sequence Detail 6969 C57BL/6J ±  kb
    transcript OTTMUST00000151434 VEGA | MGI Sequence Detail 1569 Not Applicable  
    polypeptide OTTMUSP00000078536 VEGA | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      24 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      Genomic 15
      cDNA 114
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10800, MGD-MRK-34114, MGD-MRK-38247, MGI:106420, MGI:109203
    References
    more
    • Summaries
      All 273
      Developmental Gene Expression 19
      Diseases 5
      Gene Ontology 10
      Phenotypes 103
    • Earliest
      J:31021 Kageyama H, et al., Isolation and characterization of a complementary DNA clone for a Mr 32,000 protein which is induced with tumor promoters in BALB/c 3T3 cells. Cancer Res. 1988 Sep 1;48(17):4795-8
    • Latest
      J:258257 Kozakowska M, et al., Lack of Heme Oxygenase-1 Induces Inflammatory Reaction and Proliferation of Muscle Satellite Cells after Cardiotoxin-Induced Skeletal Muscle Injury. Am J Pathol. 2018 Feb;188(2):491-506

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory