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Hmox1
Gene Detail
 Symbol
Name
ID
Hmox1
heme oxygenase (decycling) 1
MGI:96163
Synonyms D8Wsu38e, heme oxygenase 1, Hmox, HO1, HO-1, Hsp32
Feature Type protein coding gene
Genetic Map
Chromosome 8
35.59 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr8:75093591-75100596 bp, + strand
From VEGA annotation of GRCm38

  7006 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: heme oxygenase (decyclizing)
Gene Tree: Hmox1

Human
homologs
Human Homolog HMOX1, heme oxygenase (decycling) 1
NCBI Gene ID 3162
neXtProt AC  NX_P09601
Human Synonyms  bK286B10, HMOX1D, HO-1, HSP32
Human Chr (Location)  22q13.1; chr22:35381067-35394214 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human HMOX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(6) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit low serum iron levels, increased hepatic and renal iron, oxidative damage, tissue injury, chronic inflammation, reduced neuronal proliferation, and increased sensitivity to hypoxia.
 
Human Diseases Modeled Using Mouse Hmox1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Hmox1 interacts with 93 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process angiogenesis, apoptotic process, ...
Component caveola, cytosol, ...
Function enzyme binding, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (307)    Tissues (127)    Images (34)
Theiler Stages: 2, 3, 4, 5, 9, 11, 17, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 21
RNA in situ 245
Northern blot 25
Western blot 3
RT-PCR 13
cDNA source data(111)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(130) Genomic(15) cDNA(113) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000030644 (Evidence)
Ensembl Gene ModelENSMUSG00000005413 (Evidence)
Entrez Gene15368 (Evidence)
UniGene276389
DFCITC1572509
DoTSDT.533097, DT.55200845
NIA Mouse Gene IndexU009507
EC1.14.99.3
Consensus CDS ProjectCCDS22423.1
International Mouse Knockout Project StatusHmox1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030644 VEGA Gene Model | MGI Sequence Detail 7006 C57BL/6J ±  kb
transcript OTTMUST00000075866 VEGA | MGI Sequence Detail 1606 Not Applicable 
polypeptide OTTMUSP00000039843 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002051 Haem oxygenase
InterPro IPR018207 Haem oxygenase conserved site
InterPro IPR016053 Haem oxygenase-like
InterPro IPR016084 Haem oxygenase-like, multi-helical
Protein Ontology PR:000008644 heme oxygenase 1
References (Earliest) J:31021 Kageyama H, et al., Isolation and characterization of a complementary DNA clone for a Mr 32,000 protein which is induced with tumor promoters in BALB/c 3T3 cells. Cancer Res. 1988 Sep 1;48(17):4795-8
(Latest) J:210804 Haldar M, et al., Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell. 2014 Mar 13;156(6):1223-34
All references(176)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10800, MGD-MRK-34114, MGD-MRK-38247, MGI:106420, MGI:109203

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory