Hmox1
Gene Detail

Symbol Name ID

Hmox1 heme oxygenase (decycling) 1 MGI:96163

Synonyms

D8Wsu38e, heme oxygenase 1, Hmox, HO1, HO-1, Hsp32

Feature Type

protein coding gene

Genetic Map

Chromosome 8

35.59 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr8:75093591-75100596 bp, + strand From VEGA annotation of GRCm38   7006 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: heme oxygenase (decyclizing)
Gene Tree: Hmox1

Human homologs

Human Homolog		HMOX1, heme oxygenase (decycling) 1
NCBI Gene ID		3162
neXtProt AC		NX_P09601
Human Synonyms		bK286B10, HMOX1D, HO-1, HSP32
Human Chr (Location)		22q13.1; chr22:35777060-35790207 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human HMOX1

Alleles and phenotypes

All alleles(11) : Targeted(5) Gene trapped(6)
 

Homozygotes for targeted null mutations exhibit low serum iron levels, increased hepatic and renal iron, oxidative damage, tissue injury, chronic inflammation, reduced neuronal proliferation, and increased sensitivity to hypoxia.

 
Human Diseases Modeled Using Mouse Hmox1 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (57 annotations)

Process	angiogenesis, cell death, ...
Component	caveola, cytosol, ...
Function	enzyme binding, heme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (313)    Tissues (132)    Images (34)
Theiler Stages: 2, 3, 4, 5, 9, 11, 17, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	21
RNA in situ	245
Northern blot	25
Western blot	3
RT-PCR	19

cDNA source data(109)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(128) Genomic(15) cDNA(111) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000030644 (Evidence)
Ensembl Gene Model	ENSMUSG00000005413 (Evidence)
Entrez Gene	15368 (Evidence)
UniGene	276389
DFCI	TC1572509
DoTS	DT.533097, DT.55200845
NIA Mouse Gene Index	U009507
EC	1.14.99.3
Consensus CDS Project	CCDS22423.1
International Mouse Knockout Project Status	Hmox1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030644	VEGA Gene Model | MGI Sequence Detail	7006	C57BL/6J
transcript	OTTMUST00000075866	VEGA | MGI Sequence Detail	1606	Not Applicable
polypeptide	OTTMUSP00000039843	VEGA | MGI Sequence Detail	289	Not Applicable

All sequences(53) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(13 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002051	Haem oxygenase
InterPro	IPR018207	Haem oxygenase conserved site
InterPro	IPR016053	Haem oxygenase-like
InterPro	IPR016084	Haem oxygenase-like, multi-helical
Protein Ontology	PR:000008644	heme oxygenase 1

References

(Earliest) J:31021 Kageyama H, et al., Isolation and characterization of a complementary DNA clone for a Mr 32,000 protein which is induced with tumor promoters in BALB/c 3T3 cells. Cancer Res. 1988 Sep 1;48(17):4795-8
(Latest) J:192884 Starzynski RR, et al., Ferroportin expression in haem oxygenase 1-deficient mice. Biochem J. 2013 Jan 1;449(1):69-78
All references(165)

Other accession IDs

MGD-MRK-10800, MGD-MRK-34114, MGD-MRK-38247, MGI:106420, MGI:109203