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Hmox1
Gene Detail
Symbol

Name
ID
Hmox1
heme oxygenase 1
MGI:96163
Synonyms
D8Wsu38e, heme oxygenase 1, Hmox, HO1, HO-1, Hsp32
Feature Type
protein coding gene
Genetic Map
Chromosome 8
35.59 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr8:75093591-75100596 bp, + strand
From VEGA annotation of GRCm38

  7006 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HMOX1
Protein SuperFamily: heme oxygenase (decyclizing)
Gene Tree: Hmox1

Human
homologs
HMOX1, heme oxygenase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3162
neXtProt AC: NX_P09601

Human Synonyms: bK286B10, HMOX1D, HO-1, HSP32

Human Chr (Location): 22q13.1; chr22:35381067-35394214 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human HMOX1

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(6) Targeted(5) Transgenic(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit low serum iron levels, increased hepatic and renal iron, oxidative damage, tissue injury, chronic inflammation, reduced neuronal proliferation, and increased sensitivity to hypoxia.
 
Human Diseases Modeled in Mice Using Hmox1 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(5)
Interactions
Hmox1 interacts with 93 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (62 annotations)
Process angiogenesis, apoptotic process, ...
Component caveola, cytosol, ...
Function enzyme binding, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (307)    Tissues (127)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 21
RNA in situ 245
Northern blot 25
Western blot 3
RT-PCR 13
cDNA source data(111)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hmox1 ; ZFIN hmox1a, hmox1b    NEW 
Molecular
reagents
All nucleic(130) Genomic(15) cDNA(113) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000030644 (Evidence)
Ensembl Gene Model ENSMUSG00000005413 (Evidence)
Entrez Gene 15368 (Evidence)
UniGene 276389
DFCI TC1572509
DoTS DT.533097, DT.55200845
NIA Mouse Gene Index U009507
EC 1.14.99.3
Consensus CDS Project CCDS22423.1
International Mouse Phenotyping Consortium Status Hmox1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030644 VEGA Gene Model | MGI Sequence Detail 7006 C57BL/6J ±  kb
transcript OTTMUST00000075866 VEGA | MGI Sequence Detail 1606 Not Applicable 
polypeptide OTTMUSP00000039843 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002051 Haem oxygenase
InterPro IPR018207 Haem oxygenase conserved site
InterPro IPR016053 Haem oxygenase-like
InterPro IPR016084 Haem oxygenase-like, multi-helical
Protein Ontology PR:000008644 heme oxygenase 1
References
(Earliest) J:31021 Kageyama H, et al., Isolation and characterization of a complementary DNA clone for a Mr 32,000 protein which is induced with tumor promoters in BALB/c 3T3 cells. Cancer Res. 1988 Sep 1;48(17):4795-8
(Latest) J:222173 Solano ME, et al., Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation. J Clin Invest. 2015 Apr;125(4):1726-38
All references(183)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10800, MGD-MRK-34114, MGD-MRK-38247, MGI:106420, MGI:109203

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory