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Hmox1tm1Poss
Targeted Allele Detail
Summary
Symbol: Hmox1tm1Poss
Name: heme oxygenase 1; targeted mutation 1, Kenneth D Poss
MGI ID: MGI:2388322
Synonyms: Hmox1-, HO-1-, HO1-
Gene: Hmox1  Location: Chr8:75820249-75827217 bp, + strand  Genetic Position: Chr8, 35.59 cM, cytoband C1
Alliance: Hmox1tm1Poss page
Iron-loading of Hmox1tm1Poss/Hmox1tm1Poss tissues.

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79254
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 3.7 kb fragment encompassing exons 3, 4, and a portion of 5 was replaced with a neomycin selection cassette. The deleted region consisted of approximately 85% of the coding region (226 residues). A low level of aberrantly spliced transcript was identified in homozygous mutant mice by Northern blot analysis of total splenic RNA. (J:79254)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 48 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hmox1 Mutation:  33 strains or lines available
References
Original:  J:79254 Poss KD, et al., Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10919-24
All:  60 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory