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| Caption | A: Kidney section from a 50 week old Hmox1tm1Poss/+ mouse stained with Prussian blue for detection of loosely bound ferric iron, shown at low magnification. Stainable renal iron was rarely detectable in heterozygous or wild-type mice. B: Kidney section from a 50 week old Hmox1tm1Poss/Hmox1tm1Poss mouse stained with Prussian blue. Note the intense blue positive staining in the proximal cortical tubules (arrows). C: Liver section from a 50 week old heterozygous mouse stained with Prussian blue and at low magnification, displaying no hepatic iron deposits. D: Liver section from 50 week old homozygous mouse stained with Prussian blue, demonstrating iron-loaded Kupffer cells (arrows), as well as diffusely staining hepatocytes. Note the faint-staining regenerative nodule indicative of injury (*). E: High-magnification view of liver from 50 week old heterozygous mouse stained with Prussian blue, displaying no detectable iron in hepatocytes. F: High-magnification view of liver section from 50 week old homozygous mouse stained with Prussian blue, indicating iron-positive granules in hepatocytes (arrowheads), and intensely staining Kupffer cells (arrows). All magnification bars: 100um | ||||
| Copyright | This image is from Poss KD, Proc Natl Acad Sci U S A 1997 Sep 30;94(20):10919-24. Copyright 1997 National Academy of Sciences, U.S.A. J:79254 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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