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Hmgcr Gene Detail
Summary
  • Symbol
    Hmgcr
  • Name
    3-hydroxy-3-methylglutaryl-Coenzyme A reductase
  • Synonyms
    3-hydroxy-3-methylglutaryl-CoA reductase, HMG-CoAR, Red
  • Feature Type
    protein coding gene
  • IDs
    MGI:96159
    NCBI Gene: 15357
  • Gene Overview
    MyGene.info: HMGCR
Location & Maps
more
  • Sequence Map
    Chr13:96648967-96670936 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21970 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase
    Orthology source: HomoloGene
  • Synonyms
    LDLCQ3
  • Links
    NCBI Gene ID: 3156
    neXtProt AC: NX_P04035

  • Chr Location
    5q13.3-q14; chr5:75336334-75362101 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human HMGCR associations

Human Disease Mouse Models
       3-hydroxy-3-Methylglutaryl-Coa Reductase; HMGCR   OMIM: 142910
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 2 alleles in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Inactivation of both copies of this gene results in early embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035511 VEGA Gene Model | MGI Sequence Detail 21970 C57BL/6J ±  kb
transcript OTTMUST00000090933 VEGA | MGI Sequence Detail 4425 Not Applicable  
polypeptide OTTMUSP00000050014 VEGA | MGI Sequence Detail 887 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    158 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000008636 3-hydroxy-3-methylglutaryl-coenzyme A reductase
  • EC
  • InterPro Domains
    IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
    IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain
    IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
    IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
    IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain
    IPR004554 Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type
    IPR004816 Hydroxymethylglutaryl-CoA reductase, metazoan
    IPR023282 Hydroxymethylglutaryl-CoA reductase, N-terminal
    IPR000731 Sterol-sensing domain
Molecular
Reagents
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  • All nucleic 269
    cDNA 265
    Primer pair 2
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-10795
References
more
  • Summaries
    All 70
    Developmental Gene Expression 16
    Gene Ontology 15
    Phenotypes 9
  • Earliest
    J:10019 Sundaresan S, et al., Genes for HMG-CoA reductase and serotonin 1a receptor are on mouse chromosome 13. Somat Cell Mol Genet. 1989 Sep;15(5):465-9
  • Latest
    J:227474 Fonseca TL, et al., Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14018-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory