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Hmgcr
Gene Detail
Symbol

Name
ID
Hmgcr
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
MGI:96159
Synonyms
3-hydroxy-3-methylglutaryl-CoA reductase, HMG-CoAR, Red
Feature Type
protein coding gene
Genetic Map
Chromosome 13
50.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr13:96648967-96670936 bp, - strand
From VEGA annotation of GRCm38

  21970 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30994  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HMGCR
Protein SuperFamily: hydroxymethylglutaryl-CoA (HMG-CoA) reductase
Gene Tree: Hmgcr

Human
homologs
HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3156
neXtProt AC: NX_P04035

Human Synonyms: LDLCQ3

Human Chr (Location): 5q13.3-q14; chr5:75336334-75362101 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HMGCR

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Inactivation of both copies of this gene results in early embryonic lethality.
 
Interactions
Hmgcr interacts with 282 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (86)    Tissues (29)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 83
Western blot 3
cDNA source data(263)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HMGCR ; Xenbase hmgcr ; ZFIN hmgcra, hmgcrb    NEW 
Molecular
reagents
All nucleic(269) cDNA(265) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000035511 (Evidence)
Ensembl Gene Model ENSMUSG00000021670 (Evidence)
Entrez Gene 15357 (Evidence)
UniGene 316652
DFCI TC1572260, TC1595504, TC1613591, TC1737024
DoTS DT.101308614, DT.101393956, DT.534501, DT.97395214
NIA Mouse Gene Index U035064
EC 1.1.1.34
Consensus CDS Project CCDS26706.1
International Mouse Phenotyping Consortium Status Hmgcr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035511 VEGA Gene Model | MGI Sequence Detail 21970 C57BL/6J ±  kb
transcript OTTMUST00000090933 VEGA | MGI Sequence Detail 4425 Not Applicable 
polypeptide OTTMUSP00000050014 VEGA | MGI Sequence Detail 887 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(6) UniProt(10)
Polymorphisms
RFLP(6) : SNPs within 2kb(162 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
InterPro IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain
InterPro IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
InterPro IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
InterPro IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain
InterPro IPR004554 Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type
InterPro IPR004816 Hydroxymethylglutaryl-CoA reductase, metazoan
InterPro IPR023282 Hydroxymethylglutaryl-CoA reductase, N-terminal
InterPro IPR000731 Sterol-sensing domain
Protein Ontology PR:000008636 3-hydroxy-3-methylglutaryl-coenzyme A reductase
References
(Earliest) J:10019 Sundaresan S, et al., Genes for HMG-CoA reductase and serotonin 1a receptor are on mouse chromosome 13. Somat Cell Mol Genet. 1989 Sep;15(5):465-9
(Latest) J:220990 Cunningham D, et al., Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development. Hum Mol Genet. 2015 May 15;24(10):2808-25
All references(70)
Other
accession IDs
MGD-MRK-10795

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory