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Hmgcr
Gene Detail
Symbol

Name
ID
Hmgcr
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
MGI:96159
Synonyms
3-hydroxy-3-methylglutaryl-CoA reductase, HMG-CoAR, Red
Feature Type
protein coding gene
Genetic Map
Chromosome 13
50.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr13:96648967-96670936 bp, - strand
From VEGA annotation of GRCm38

  21970 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30994  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: hydroxymethylglutaryl-CoA (HMG-CoA) reductase
Gene Tree: Hmgcr

Human
homologs
Human Homolog HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase
NCBI Gene ID 3156
neXtProt AC  NX_P04035
Human Synonyms  LDLCQ3
Human Chr (Location)  5q13.3-q14; chr5:75337168-75362101 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HMGCR
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of both copies of this gene results in early embryonic lethality.
 
Interactions
Hmgcr interacts with 282 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (12 records)
Data Summary: Results (86)    Tissues (29)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 83
Western blot 3
cDNA source data(263)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(269) cDNA(265) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000035511 (Evidence)
Ensembl Gene ModelENSMUSG00000021670 (Evidence)
Entrez Gene15357 (Evidence)
UniGene316652
DFCITC1572260, TC1595504, TC1613591, TC1737024
DoTSDT.101308614, DT.101393956, DT.534501, DT.97395214
NIA Mouse Gene IndexU035064
EC1.1.1.34
Consensus CDS ProjectCCDS26706.1
International Mouse Knockout Project StatusHmgcr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035511 VEGA Gene Model | MGI Sequence Detail 21970 C57BL/6J ±  kb
transcript OTTMUST00000090933 VEGA | MGI Sequence Detail 4425 Not Applicable 
polypeptide OTTMUSP00000050014 VEGA | MGI Sequence Detail 887 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(8) UniProt(19)
Polymorphisms
RFLP(6) : SNPs within 2kb(162 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
InterPro IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain
InterPro IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
InterPro IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding
InterPro IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding
InterPro IPR004554 Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type
InterPro IPR004816 Hydroxymethylglutaryl-CoA reductase, metazoan
InterPro IPR023282 Hydroxymethylglutaryl-CoA reductase, N-terminal
InterPro IPR000731 Sterol-sensing domain
Protein Ontology PR:000008636 3-hydroxy-3-methylglutaryl-coenzyme A reductase
References
(Earliest) J:10019 Sundaresan S, et al., Genes for HMG-CoA reductase and serotonin 1a receptor are on mouse chromosome 13. Somat Cell Mol Genet. 1989 Sep;15(5):465-9
(Latest) J:198551 Buchovecky CM, et al., A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett Syndrome. Nat Genet. 2013;45(9):1013-20
All references(70)
Other
accession IDs
MGD-MRK-10795

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory