Gene Expression Literature Summary

• Symbol: Hmgcr
• Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
• ID: MGI:96159

30 matching records from 30 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14.5	E15	E16.5	E17.5	E18.5	E19.5	E	P
Immunohistochemistry (section)	1				1				1
In situ RNA (section)						1	3
In situ RNA (whole mount)		1	1		1	1	1
Northern blot										1	1	1		2
Western blot							1		1		1			1
RT-PCR	2		2	1				1	2		1			17
RNase protection													1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hmgcr  3-hydroxy-3-methylglutaryl-Coenzyme A reductase   (Synonyms: 3-hydroxy-3-methylglutaryl-CoA reductase, HMG-CoAR, Red)
Results	Reference
1*	J:325730 Ahuja N, Hiltabidle MS, Rajasekhar H, Voss S, Lu SZ, Barlow HR, Cowdin MA, Daniel E, Vaddaraju V, Anandakumar T, Black E, Cleaver O, Maynard C, Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95
1*	J:88490 Beigneux AP, Kosinski C, Gavino B, Horton JD, Skarnes WC, Young SG, ATP-citrate lyase deficiency in the mouse. J Biol Chem. 2004 Mar 5;279(10):9557-64
1*	J:157050 Bojanic DD, Tarr PT, Gale GD, Smith DJ, Bok D, Chen B, Nusinowitz S, Lovgren-Sandblom A, Bjorkhem I, Edwards PA, Differential expression and function of ABCG1 and ABCG4 during development and aging. J Lipid Res. 2010 Jan;51(1):169-81
1	J:106993 Briancon N, Weiss MC, In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping. EMBO J. 2006 Mar 22;25(6):1253-62
1	J:198551 Buchovecky CM, Turley SD, Brown HM, Kyle SM, McDonald JG, Liu B, Pieper AA, Huang W, Katz DM, Russell DW, Shendure J, Justice MJ, A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett Syndrome. Nat Genet. 2013;45(9):1013-20
1	J:220990 Cunningham D, DeBarber AE, Bir N, Binkley L, Merkens LS, Steiner RD, Herman GE, Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development. Hum Mol Genet. 2015 May 15;24(10):2808-25
1	J:137156 Desmazieres A, Decker L, Vallat JM, Charnay P, Gilardi-Hebenstreit P, Disruption of Krox20-Nab interaction in the mouse leads to peripheral neuropathy with biphasic evolution. J Neurosci. 2008 Jun 4;28(23):5891-900
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:145847 Ding J, Jiang D, Kurczy M, Nalepka J, Dudley B, Merkel EI, Porter FD, Ewing AG, Winograd N, Burgess J, Molyneaux K, Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse. BMC Dev Biol. 2008;8:120
3	J:336898 Edwards W, Greco TM, Miner GE, Barker NK, Herring L, Cohen S, Cristea IM, Conlon FL, Quantitative proteomic profiling identifies global protein network dynamics in murine embryonic heart development. Dev Cell. 2023 Jun 19;58(12):1087-1105.e4
3	J:227474 Fonseca TL, Fernandes GW, McAninch EA, Bocco BM, Abdalla SM, Ribeiro MO, Mohacsik P, Fekete C, Li D, Xing X, Wang T, Gereben B, Bianco AC, Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14018-23
1*	J:306194 Ghimire S, Kim J, PEG3 controls lipogenesis through ACLY. PLoS One. 2021;16(5):e0252354
1	J:343810 Guo CG, Sun R, Wang X, Yuan Y, Xu Y, Li S, Sun X, Wang J, Hu X, Guo T, Chen XW, Xiao RP, Zhang X, Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion. Mol Metab. 2023 Nov 30;79:101847
2	J:74083 Hanaka S, Abe T, Itakura H, Matsumoto A, Gene expression related to cholesterol metabolism in mouse brain during development. Brain Dev. 2000 Aug;22(5):321-6
3*	J:190090 Hasegawa S, Kume H, Iinuma S, Yamasaki M, Takahashi N, Fukui T, Acetoacetyl-CoA synthetase is essential for normal neuronal development. Biochem Biophys Res Commun. 2012 Oct 19;427(2):398-403
1	J:271920 Hong AE, Ryu MS, Kim SJ, Hwang SY, Lim IK, PPARalpha-Target Gene Expression Requires TIS21(/BTG2) Gene in Liver of the C57BL/6 Mice under Fasting Condition. Mol Cells. 2018 Feb 28;41(2):140-149
1	J:240829 Jiang M, Liu L, He X, Wang H, Lin W, Wang H, Yoon SO, Wood TL, Lu QR, Regulation of PERK-eIF2alpha signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes. Nat Commun. 2016 Jul 15;7:12185
2	J:272610 Kim M, Wende H, Walcher J, Kuhnemund J, Cheret C, Kempa S, McShane E, Selbach M, Lewin GR, Birchmeier C, Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells. Genes Dev. 2018 May 1;32(9-10):645-657
2	J:338938 Kobayashi K, Iwasa K, Azuma-Suzuki R, Kawauchi T, Nabeshima YI, Feto-maternal cholesterol transport regulated by beta-Klotho-FGF15 axis is essential for fetal growth. Life Sci Alliance. 2023 Oct;6(10)
5*	J:85283 Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R, Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. Mol Endocrinol. 2003 Sep;17(9):1715-25
1*	J:221086 Patra D, DeLassus E, Liang G, Sandell LJ, Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis. PLoS One. 2014;9(8):e105674
1	J:154113 Sacchetti P, Sousa KM, Hall AC, Liste I, Steffensen KR, Theofilopoulos S, Parish CL, Hazenberg C, Richter LA, Hovatta O, Gustafsson JA, Arenas E, Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Cell Stem Cell. 2009 Oct 2;5(4):409-19
1	J:287213 Scortegagna M, Berthon A, Settas N, Giannakou A, Garcia G, Li JL, James B, Liddington RC, Vilches-Moure JG, Stratakis CA, Ronai ZA, The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion. JCI Insight. 2017 Dec 7;2(23)
1*	J:256230 Shin SW, John Vogt E, Jimenez-Movilla M, Baibakov B, Dean J, Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. Nat Commun. 2017 Nov 21;8(1):1643
2	J:224387 Sisecioglu M, Budak H, Geffers L, Cankaya M, Ciftci M, Thaller C, Eichele G, Kufrevioglu OI, Ozdemir H, A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo. J Lipid Res. 2015 Aug;56(8):1551-9
1	J:264124 Tsushima H, Tang YJ, Puviindran V, Hsu SC, Nadesan P, Yu C, Zhang H, Mirando AJ, Hilton MJ, Alman BA, Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. Development. 2018 Jul 9;145(13):dev162396
1	J:291257 Van Veldhoven PP, de Schryver E, Young SG, Zwijsen A, Fransen M, Espeel M, Baes M, Van Ael E, Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid. Front Cell Dev Biol. 2020;8:144
2	J:231339 Vergnes L, Chin RG, de Aguiar Vallim T, Fong LG, Osborne TF, Young SG, Reue K, SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression. J Lipid Res. 2016 Mar;57(3):410-21
2*	J:299531 Wei L, Zheng YY, Sun J, Wang P, Tao T, Li Y, Chen X, Sang Y, Chong D, Zhao W, Zhou Y, Wang Y, Jiang Z, Qiu T, Li CJ, Zhu MS, Zhang X, GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism. J Biol Chem. 2020 Nov 20;295(47):15988-16001
4	J:91859 Yubero P, Hondares E, Carmona MC, Rossell M, Gonzalez FJ, Iglesias R, Giralt M, Villarroya F, The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism. Endocrinology. 2004 Sep;145(9):4268-77