Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.3.0)

Enables GTPase regulator activity and hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in several processes, including lipid biosynthetic process; negative regulation of amyloid-beta clearance; and negative regulation of protein secretion. Acts upstream of or within several processes, including long-term synaptic potentiation; regulation of MAPK cascade; and visual learning. Is active in cytoplasmic side of endoplasmic reticulum membrane. Is expressed in several structures, including autopod; branchial arch; central nervous system; ganglia; and heart valve. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase).

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Gene Ontology Evidence Code Abbreviations:

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