Hmgcr Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hmgcr
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
MGI:96159

34 phenotypes from 3 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hmgcr^em1Bcgen/Hmgcr^em1Bcgen Not Specified	normal homeostasis/metabolism phenotype	J:299971
Hmgcr^em1Bcgen/Hmgcr^em1Bcgen Not Specified	increased circulating triglyceride level	J:299971
Hmgcr^tm1Ishi/Hmgcr⁺ involves: 129S7/SvEvBrd * C57BL/6J	no abnormal phenotype detected	J:86378
Hmgcr^tm1Ishi/Hmgcr^tm1Ishi involves: 129S7/SvEvBrd * C57BL/6J	embryonic lethality, complete penetrance	J:86378
Hmgcr^tm2Ishi/Hmgcr^tm2Ishi involves: 129S7/SvEvBrd * C57BL/6J	no abnormal phenotype detected	J:201488
Hmgcr^tm2Ishi/Hmgcr^tm2Ishi Tg(Alb1-cre)1Dlr/0 involves: 129S7/SvEvBrd * C57BL/6J	abnormal circulating apolipoprotein level	J:201488
	abnormal circulating lipoprotein level	J:201488
	abnormal liver parenchyma morphology	J:201488
	abnormal liver physiology	J:201488
	decreased circulating cholesterol level	J:201488
	decreased circulating LDL cholesterol level	J:201488
	decreased circulating triglyceride level	J:201488
	decreased liver cholesterol level	J:201488
	enlarged liver	J:201488
	hepatic necrosis	J:201488
	hypoglycemia	J:201488
	increased circulating alanine transaminase level	J:201488
	increased circulating aspartate transaminase level	J:201488
	increased circulating bilirubin level	J:201488
	increased circulating cholesterol level	J:201488
	increased circulating free fatty acids level	J:201488
	increased circulating LDL cholesterol level	J:201488
	increased circulating phospholipid level	J:201488
	increased collagen level	J:201488
	increased fatty acids level	J:201488
	increased liver triglyceride level	J:201488
	increased liver weight	J:201488
	increased unsaturated fatty acids level	J:201488
	jaundice	J:201488
	liver failure	J:201488
	microvesicular hepatic steatosis	J:201488
	pale liver	J:201488
	postnatal lethality, incomplete penetrance	J:201488
	premature death	J:201488
	weight loss	J:201488

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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