Symbol
Name
ID

Hmgcr
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
MGI:96159

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Increased LDL cholesterol concentration	Hypercholesterolemia	Hypertriglyceridemia	Glucose intolerance	Diabetes mellitus	Type II diabetes mellitus	Impaired glucose tolerance	Insulin resistance
Disease(s) Associated with HMGCR	Increased LDL cholesterol concentration	Hypercholesterolemia	Hypertriglyceridemia	Glucose intolerance	Diabetes mellitus	Type II diabetes mellitus	Impaired glucose tolerance	Insulin resistance
coronary artery disease
type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

increased circulating bilirubin level

hypoglycemia

decreased circulating LDL cholesterol level

increased circulating LDL cholesterol level

decreased circulating cholesterol level

increased circulating cholesterol level

increased circulating free fatty acids level

increased circulating phospholipid level

decreased circulating triglyceride level

increased circulating triglyceride level

abnormal circulating lipoprotein level

abnormal circulating apolipoprotein level

increased circulating alanine transaminase level

increased circulating aspartate transaminase level

decreased liver cholesterol level

increased fatty acids level

increased unsaturated fatty acids level

increased liver triglyceride level

increased collagen level

Availability

Mouse Genotype

Hmgcr^em1Bcgen/Hmgcr^em1Bcgen

Hmgcr^tm2Ishi/Hmgcr^tm2Ishi
Tg(Alb1-cre)1Dlr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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