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Nrg1 Gene Detail
Summary
  • Symbol
    Nrg1
  • Name
    neuregulin 1
  • Synonyms
    6030402G23Rik, ARIA, D230005F13Rik, GGF, GGFII, heregulin, Hgl, HGL, HRG, HRGalpha, NDF, SMDF
  • Feature Type
    protein coding gene
  • IDs
    MGI:96083
    NCBI Gene: 211323
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:32299493-33381858 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 18.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    44490 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96083
 protein coding gene Chr8:32299493-33381858 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033518
 protein coding gene Chr8:30231843-30339757 (-)
A/J MGP_AJ_G0033498
 protein coding gene Chr8:29069334-29172852 (-)
AKR/J MGP_AKRJ_G0033422
 protein coding gene Chr8:29983929-30087790 (-)
BALB/cJ MGP_BALBcJ_G0033494
 protein coding gene Chr8:29201443-29302109 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0034010
 protein coding gene Chr8:31374072-31481676 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030959
 protein coding gene Chr8:25923556-26023956 (-)
CAST/EiJ MGP_CASTEiJ_G0032533
 protein coding gene Chr8:29677446-29779402 (-)
CBA/J MGP_CBAJ_G0033184
 protein coding gene Chr8:32622463-32733959 (-)
DBA/2J MGP_DBA2J_G0033337
 protein coding gene Chr8:29053240-29153545 (-)
FVB/NJ MGP_FVBNJ_G0033282
 protein coding gene Chr8:28765079-28869872 (-)
LP/J MGP_LPJ_G0033427
 protein coding gene Chr8:30184719-30293455 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033324
 protein coding gene Chr8:32183225-32287350 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034029
 protein coding gene Chr8:30037642-30139458 (-)
PWK/PhJ MGP_PWKPhJ_G0032245
 protein coding gene Chr8:28555350-28656650 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032077
 protein coding gene Chr8:29332213-29433215 (-)
WSB/EiJ MGP_WSBEiJ_G0032649
 protein coding gene Chr8:30158101-30262086 (-)



Homology
more
  • Human Ortholog
    NRG1, neuregulin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRG1, neuregulin 1
  • Synonyms
    ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF
  • Links
    NCBI Gene ID: 3084
    UniProt: Q02297

  • Chr Location
    8p12; chr8:31639222-32855666 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nrg1 mouse models; 16 with human NRG1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    98 phenotypes from 16 alleles in 22 genetic backgrounds
    11 phenotypes from multigenic genotypes
    1 images
    149 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit heart defects, impaired development of Schwann cell precursors, cranial ganglia, and radial glia cells, and die at embryonic day 10.5-11.5. Heterozygotes are hyperactive with reduced NMDA receptors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    176
  • GO References
    60
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    341
  • cDNA Data
    31
  • Literature Summary
    142
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 211323 NCBI Gene Model | MGI Sequence Detail 1082366 C57BL/6J ±  kb
    transcript NM_001364421 RefSeq | MGI Sequence Detail 10896 C57BL/6  
    polypeptide Q6DR98 UniProt | EBI | MGI Sequence Detail 645 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      Genomic 2
      cDNA 34
      Primer pair 24
      Other 13

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-10710, MGI:1345182, MGI:2444307, MGI:2444355
    References
    more
    • Summaries
      All 406
      Developmental Gene Expression 142
      Diseases 1
      Gene Ontology 60
      Phenotypes 149
    • Earliest
      J:22280 Orr-Urtreger A, et al., Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1867-71
    • Latest
      J:363600 Arai T, et al., Liver-derived Neuregulin1alpha stimulates compensatory pancreatic beta cell hyperplasia in insulin resistance. Nat Commun. 2025 Mar 13;16(1):1950
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory