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Nrg1 Gene Detail
Summary
  • Symbol
    Nrg1
  • Name
    neuregulin 1
  • Synonyms
    6030402G23Rik, ARIA, D230005F13Rik, GGF, GGFII, heregulin, Hgl, HGL, HRG, HRGalpha, NDF, SMDF
  • Feature Type
    protein coding gene
  • IDs
    MGI:96083
    NCBI Gene: 211323
  • Gene Overview
    MyGene.info: NRG1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr8:31814551-32884029 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      1069479 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 18.75 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NRG1, neuregulin 1
  • Vertebrate Orthologs
    2
  • Human Ortholog
    NRG1, neuregulin 1
    Orthology source: HGNC
  • Synonyms
    ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF
  • Links
    NCBI Gene ID: 3084
    neXtProt AC: NX_Q02297
    UniProt: Q02297

  • Chr Location
    8p12; chr8:31639222-32771716 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Nrg1 mouse models; 1 with human NRG1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    99 phenotypes from 16 alleles in 22 genetic backgrounds
    22 phenotypes from multigenic genotypes
    1 images
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit heart defects, impaired development of Schwann cell precursors, cranial ganglia, and radial glia cells, and die at embryonic day 10.5-11.5. Heterozygotes are hyperactive with reduced NMDA receptors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    40
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    657
  • Tissues
    288
  • cDNA Data
    27
  • Literature Summary
    94
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000059179 VEGA Gene Model | MGI Sequence Detail 1069479 C57BL/6J ±  kb
    transcript OTTMUST00000145244 VEGA | MGI Sequence Detail 2452 Not Applicable  
    polypeptide OTTMUSP00000075698 VEGA | MGI Sequence Detail 700 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      10462 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 2
      cDNA 30
      Primer pair 6
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-10710, MGI:1345182, MGI:2444307, MGI:2444355
    References
    more
    • Summaries
      All 264
      Developmental Gene Expression 94
      Diseases 2
      Gene Ontology 40
      Phenotypes 91
    • Earliest
      J:22280 Orr-Urtreger A, et al., Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1867-71
    • Latest
      J:259182 Silva CG, et al., Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis. Cell. 2018 Feb 22;172(5):1063-1078.e19
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory