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Nrg1
Gene Detail
Symbol

Name
ID
Nrg1
neuregulin 1
MGI:96083
Synonyms
6030402G23Rik, ARIA, D230005F13Rik, GGF, GGFII, heregulin, Hgl, HGL, HRG, HRGalpha, NDF, SMDF
Feature Type
protein coding gene
Genetic Map
Chromosome 8
18.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:31818028-31918203 bp, - strand
From Ensembl annotation of GRCm38

  100176 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:138451  Vertebrate Homology Class
1 mouse; 1 chicken

HCOP human homology predictions: NRG1
Protein SuperFamily: heregulin
Gene Tree: Nrg1

Human
homologs
NRG1, neuregulin 1
Orthology source: HGNC

IDs:
NCBI Gene ID: 3084
neXtProt AC: NX_Q02297

Human Synonyms: ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF

Human Chr (Location): 8p12; chr8:31639304-32767957 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NRG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(1) Targeted(13)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit heart defects, impaired development of Schwann cell precursors, cranial ganglia, and radial glia cells, and die at embryonic day 10.5-11.5. Heterozygotes are hyperactive with reduced NMDA receptors.
 
Human Diseases Modeled in Mice Using Nrg1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (69 annotations)
Process activation of transmembrane receptor protein tyrosine kinase activity, axon ensheathment, ...
Component axolemma, axon, ...
Function chemorepellent activity, ErbB-2 class receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (82 records)
Data Summary: Results (553)    Tissues (225)    Images (90)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 489
In situ reporter (knock in) 38
Western blot 4
RT-PCR 10
cDNA source data(25)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100496613    NEW 
Molecular
reagents
All nucleic(34) Genomic(2) cDNA(26) Primer pair(5) Other(1)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000062991 (Evidence)
Entrez Gene 211323 (Evidence)
DFCI TC1587751, TC1589778, TC1618477, TC1631053
DoTS DT.101250768, DT.101270808, DT.103559932, DT.110885346, DT.91334987, DT.91361545, DT.91387806, DT.91393502
NIA Mouse Gene Index U029697
Consensus CDS Project CCDS40315.1
International Mouse Phenotyping Consortium Status Nrg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062991 Ensembl Gene Model | MGI Sequence Detail 100176 C57BL/6J ±  kb
transcript ENSMUST00000073884 Ensembl | MGI Sequence Detail 2103 Not Applicable 
polypeptide ENSMUSP00000073546 Ensembl | MGI Sequence Detail 700 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(63) UniProt(6)
Polymorphisms
SNPs within 2kb(1019 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR018250 Neuregulin-1
InterPro IPR002154 Neuregulin, C-terminal
Protein Ontology PR:000029649 pro-neuregulin-1, membrane-bound isoform
References
(Earliest) J:22280 Orr-Urtreger A, et al., Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1867-71
(Latest) J:222626 McClelland KS, et al., Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells. Biol Reprod. 2015 Jun;92(6):145
All references(196)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10710, MGI:1345182, MGI:2444307, MGI:2444355

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory