Nrg1
Gene Detail

Symbol

Name
ID

Nrg1
neuregulin 1
MGI:96083

Synonyms

6030402G23Rik, ARIA, D230005F13Rik, GGF, GGFII, heregulin, Hgl, HGL, HRG, HRGalpha, NDF, SMDF

Feature Type

protein coding gene

Genetic Map

Chromosome 8
18.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:31818028-31918203 bp, - strand From Ensembl annotation of GRCm38   100176 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:138451  Vertebrate Homology Class
1 mouse; 1 chicken

Protein SuperFamily: heregulin
Gene Tree: Nrg1

Mutations,
alleles, and
phenotypes

All mutations/alleles(14) : Chemically induced (ENU)(1) Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for targeted null mutations exhibit heart defects, impaired development of Schwann cell precursors, cranial ganglia, and radial glia cells, and die at embryonic day 10.5-11.5. Heterozygotes are hyperactive with reduced NMDA receptors.

 
Human Diseases Modeled in Mice Using Nrg1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)

Gene Ontology
(GO)
classifications

All GO classifications: (42 annotations)

Process	activation of transmembrane receptor protein tyrosine kinase activity, cardiac conduction system development, ...
Component	axon, cytoplasm, ...
Function	ErbB-2 class receptor binding, protein tyrosine kinase activator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (79 records)

Data Summary: Results (553)    Tissues (225)    Images (90)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	12
RNA in situ	489
In situ reporter (knock in)	38
Western blot	4
RT-PCR	10

cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(34) Genomic(2) cDNA(26) Primer pair(5) Other(1)
Microarray probesets(1)

Other database
links

Ensembl Gene Model	ENSMUSG00000062991 (Evidence)
Entrez Gene	211323 (Evidence)
DFCI	TC1587751, TC1589778, TC1618477, TC1631053
DoTS	DT.101250768, DT.101270808, DT.103559932, DT.110885346, DT.91334987, DT.91361545, DT.91387806, DT.91393502
NIA Mouse Gene Index	U029697
Consensus CDS Project	CCDS40315.1
International Mouse Knockout Project Status	Nrg1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000062991	Ensembl Gene Model | MGI Sequence Detail	100176	C57BL/6J
transcript	ENSMUST00000073884	Ensembl | MGI Sequence Detail	2103	Not Applicable
polypeptide	ENSMUSP00000073546	Ensembl | MGI Sequence Detail	700	Not Applicable

All sequences(106) RefSeq(67) UniProt(6)

Polymorphisms

SNPs within 2kb(1019 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR018250	Neuregulin
InterPro	IPR002154	Neuregulin 1-related, C-terminal
Protein Ontology	PR:000029649	pro-neuregulin-1, membrane-bound isoform

References

(Earliest) J:22280 Orr-Urtreger A, et al., Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1867-71
(Latest) J:215807 Heller BA, et al., Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system. J Cell Biol. 2014 Mar 31;204(7):1219-36
All references(192)
Disease annotation references (2)

Other
accession IDs

MGD-MRK-10710, MGI:1345182, MGI:2444307, MGI:2444355