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Nrg1 Gene Detail
Summary
  • Symbol
    Nrg1
  • Name
    neuregulin 1
  • Synonyms
    6030402G23Rik, ARIA, D230005F13Rik, GGF, GGFII, heregulin, Hgl, HGL, HRG, HRGalpha, NDF, SMDF
  • Feature Type
    protein coding gene
  • IDs
    MGI:96083
    NCBI Gene: 211323
  • Gene Overview
    MyGene.info: NRG1
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:32299493-33381858 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 18.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10462 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96083
 protein coding gene Chr8:32299493-33381858 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033518
 protein coding gene Chr8:30231843-30339757 (-)
A/J MGP_AJ_G0033498
 protein coding gene Chr8:29069334-29172852 (-)
AKR/J MGP_AKRJ_G0033422
 protein coding gene Chr8:29983929-30087790 (-)
BALB/cJ MGP_BALBcJ_G0033494
 protein coding gene Chr8:29201443-29302109 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0034010
 protein coding gene Chr8:31374072-31481676 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030959
 protein coding gene Chr8:25923556-26023956 (-)
CAST/EiJ MGP_CASTEiJ_G0032533
 protein coding gene Chr8:29677446-29779402 (-)
CBA/J MGP_CBAJ_G0033184
 protein coding gene Chr8:32622463-32733959 (-)
DBA/2J MGP_DBA2J_G0033337
 protein coding gene Chr8:29053240-29153545 (-)
FVB/NJ MGP_FVBNJ_G0033282
 protein coding gene Chr8:28765079-28869872 (-)
LP/J MGP_LPJ_G0033427
 protein coding gene Chr8:30184719-30293455 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033324
 protein coding gene Chr8:32183225-32287350 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034029
 protein coding gene Chr8:30037642-30139458 (-)
PWK/PhJ MGP_PWKPhJ_G0032245
 protein coding gene Chr8:28555350-28656650 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032077
 protein coding gene Chr8:29332213-29433215 (-)
WSB/EiJ MGP_WSBEiJ_G0032649
 protein coding gene Chr8:30158101-30262086 (-)



Homology
more
  • Human Ortholog
    NRG1, neuregulin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRG1, neuregulin 1
  • Synonyms
    ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF
  • Links
    NCBI Gene ID: 3084
    neXtProt AC: NX_Q02297
    UniProt: Q02297

  • Chr Location
    8p12; chr8:31639222-32771716 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Nrg1 mouse models; 1 with human NRG1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    99 phenotypes from 16 alleles in 22 genetic backgrounds
    22 phenotypes from multigenic genotypes
    1 images
    119 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit heart defects, impaired development of Schwann cell precursors, cranial ganglia, and radial glia cells, and die at embryonic day 10.5-11.5. Heterozygotes are hyperactive with reduced NMDA receptors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    131
  • GO References
    45
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    307
  • cDNA Data
    27
  • Literature Summary
    118
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 211323 NCBI Gene Model | MGI Sequence Detail 1082366 C57BL/6J ±  kb
    transcript NM_001364427 RefSeq | MGI Sequence Detail 6440 C57BL/6  
    polypeptide NP_001351352 RefSeq | MGI Sequence Detail 726 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 2
      cDNA 30
      Primer pair 10
      Other 4

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-10710, MGI:1345182, MGI:2444307, MGI:2444355
    References
    more
    • Summaries
      All 325
      Developmental Gene Expression 118
      Diseases 2
      Gene Ontology 45
      Phenotypes 119
    • Earliest
      J:22280 Orr-Urtreger A, et al., Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1867-71
    • Latest
      J:310654 Navarro-Gonzalez C, et al., Nrg1 haploinsufficiency alters inhibitory cortical circuits. Neurobiol Dis. 2021 Sep;157:105442
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/19/2021
    MGI 6.17     		The Jackson Laboratory