Nrg1
Gene Detail

Symbol Name ID

Nrg1 neuregulin 1 MGI:96083

Synonyms

6030402G23Rik, ARIA, D230005F13Rik, GGF, GGFII, heregulin, Hgl, HGL, HRG, HRGalpha, NDF, SMDF

Feature Type

protein coding gene

Genetic Map

Chromosome 8

18.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:31818028-31918203 bp, - strand From NCBI annotation of GRCm38   100176 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Nrg1 ± 2 cM)

Protein SuperFamily: heregulin
Gene Tree: Nrg1

Human ortholog

NRG1 neuregulin 1 NCBI Gene ID 3084
Human Synonyms: ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, NDF, SMDF
Human Chr8:31496820-32622558 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human NRG1 (1)

Alleles and phenotypes

All alleles(12) : Targeted(11) Chemically induced(1)
 

Homozygotes for targeted null mutations exhibit heart defects, impaired development of Schwann cell precursors, cranial ganglia, and radial glia cells, and die at embryonic day 10.5-11.5. Heterozygotes are hyperactive with reduced NMDA receptors.

 
Human Diseases Modeled Using Mouse Nrg1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (60 annotations)

Process	activation of transmembrane receptor protein tyrosine kinase activity, cardiac conduction system development, ...
Component	apical plasma membrane, axon, ...
Function	ErbB-2 class receptor binding, ErbB-3 class receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (70 records)
Data Summary: Results (535)    Tissues (212)    Images (83)
Theiler Stages: 9, 11, 12, 13, 14, 15, 16, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	481
In situ reporter (knock in)	38
RT-PCR	6

cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(2) cDNA(26) Primer pair(3) Other(1)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000062991 (Evidence)
Entrez Gene	211323 (Evidence)
DFCI	TC1587751, TC1589778, TC1618477, TC1631053
DoTS	DT.101250768, DT.101270808, DT.103559932, DT.110885346, DT.91334987, DT.91361545, DT.91387806, DT.91393502
NIA Mouse Gene Index	U029697
Consensus CDS Project	CCDS40315.1
International Mouse Knockout Project Status	Nrg1

Sequences

Length	Strain/Species
genomic	211323	NCBI Gene Model | MGI Sequence Detail	100176	C57BL/6J
transcript	NM_178591	RefSeq | MGI Sequence Detail	2103	C57BL/6
polypeptide	NP_848706	RefSeq | MGI Sequence Detail	700	C57BL/6

All sequences(41) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(279 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR018250	Neuregulin
InterPro	IPR002154	Neuregulin 1-related, C-terminal

References

(Earliest) J:22280 Orr-Urtreger A, et al., Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1867-71
(Latest) J:188920 Vijayaraj P, et al., Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis. Development. 2012 Nov;139(21):3973-85
All references(170)

Other accession IDs

MGD-MRK-10710, MGI:1345182, MGI:2444307, MGI:2444355