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Nrg1 Gene Detail
Summary
  • Symbol
    Nrg1
  • Name
    neuregulin 1
  • Synonyms
    6030402G23Rik, ARIA, D230005F13Rik, GGF, GGFII, heregulin, Hgl, HGL, HRG, HRGalpha, NDF, SMDF
  • Feature Type
    protein coding gene
  • IDs
    MGI:96083
    NCBI Gene: 211323
  • Gene Overview
    MyGene.info: NRG1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr8:31814551-32884029 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      1069479 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 18.75 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NRG1, neuregulin 1
  • Vertebrate Orthologs
    2
  • Human Ortholog
    NRG1, neuregulin 1
    Orthology source: HGNC
  • Synonyms
    ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF
  • Links
    NCBI Gene ID: 3084
    neXtProt AC: NX_Q02297
    UniProt: Q02297

  • Chr Location
    8p12; chr8:31639222-32771716 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Nrg1 mouse models; 1 with human NRG1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    99 phenotypes from 16 alleles in 22 genetic backgrounds
    22 phenotypes from multigenic genotypes
    1 images
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit heart defects, impaired development of Schwann cell precursors, cranial ganglia, and radial glia cells, and die at embryonic day 10.5-11.5. Heterozygotes are hyperactive with reduced NMDA receptors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    70
  • GO References
    40
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    657
  • Tissues
    288
  • cDNA Data
    27
  • Literature Summary
    90
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059179 VEGA Gene Model | MGI Sequence Detail 1069479 C57BL/6J ±  kb
transcript OTTMUST00000145244 VEGA | MGI Sequence Detail 2452 Not Applicable  
polypeptide OTTMUSP00000075698 VEGA | MGI Sequence Detail 700 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    10462 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    Genomic 2
    cDNA 30
    Primer pair 6
    Other 1

    Microarray probesets 1
Other
Accession IDs
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MGD-MRK-10710, MGI:1345182, MGI:2444307, MGI:2444355
References
more
  • Summaries
    All 261
    Developmental Gene Expression 90
    Diseases 2
    Gene Ontology 40
    Phenotypes 91
  • Earliest
    J:22280 Orr-Urtreger A, et al., Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1867-71
  • Latest
    J:258805 O''Tuathaigh CM, et al., Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 x DISC1. Schizophr Bull. 2017 Jan;43(1):214-225
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/03/2018
MGI 6.11 		The Jackson Laboratory