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Gene Detail
neuregulin 1
Synonyms 6030402G23Rik, ARIA, D230005F13Rik, GGF, GGFII, heregulin, Hgl, HGL, HRG, HRGalpha, NDF, SMDF
Feature Type protein coding gene
Genetic Map
Chromosome 8
18.75 cM
Detailed Genetic Map ± 1 cM

Mapping data(3)
Sequence Map
Chr8:31818028-31918203 bp, - strand
From NCBI annotation of GRCm38

  100176 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:138451  Vertebrate Homology Class
1 mouse; 1 chicken

Protein SuperFamily: heregulin
Gene Tree: Nrg1

alleles, and
All mutations/alleles(14) : Chemically induced (ENU)(1) Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for targeted null mutations exhibit heart defects, impaired development of Schwann cell precursors, cranial ganglia, and radial glia cells, and die at embryonic day 10.5-11.5. Heterozygotes are hyperactive with reduced NMDA receptors.
Human Diseases Modeled Using Mouse Nrg1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
All GO classifications: (36 annotations)
Process cardiac conduction system development, cell migration, ...
Component axon, cytoplasm, ...
Function ErbB-2 class receptor binding, transcription cofactor activity
External Resources: FuncBase
Literature Summary: (78 records)
Data Summary: Results (553)    Tissues (225)    Images (90)
Theiler Stages: 9, 11, 12, 13, 14, 15, 16, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 489
In situ reporter (knock in) 38
Western blot 4
cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(34) Genomic(2) cDNA(26) Primer pair(5) Other(1)
Microarray probesets(1)
Other database
Ensembl Gene ModelENSMUSG00000062991 (Evidence)
Entrez Gene211323 (Evidence)
DFCITC1587751, TC1589778, TC1618477, TC1631053
DoTSDT.101250768, DT.101270808, DT.103559932, DT.110885346, DT.91334987, DT.91361545, DT.91387806, DT.91393502
NIA Mouse Gene IndexU029697
Consensus CDS ProjectCCDS40315.1
International Mouse Knockout Project StatusNrg1
Representative SequencesLengthStrain/SpeciesFlank
genomic 211323 NCBI Gene Model | MGI Sequence Detail 100176 C57BL/6J ±  kb
transcript NM_178591 RefSeq | MGI Sequence Detail 2103 C57BL/6 
polypeptide NP_848706 RefSeq | MGI Sequence Detail 700 C57BL/6 

For the selected sequences
All sequences(106) RefSeq(67) UniProt(6)
Polymorphisms SNPs within 2kb(1019 from dbSNP Build 137)
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR018250 Neuregulin
InterPro IPR002154 Neuregulin 1-related, C-terminal
Protein Ontology PR:000029649 pro-neuregulin-1, membrane-bound isoform
References (Earliest) J:22280 Orr-Urtreger A, et al., Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1867-71
(Latest) J:211333 Shin YK, et al., Grb2-associated binder-1 is required for neuregulin-1-induced peripheral nerve myelination. J Neurosci. 2014 May 28;34(22):7657-62
All references(186)
Disease annotation references (2)
accession IDs
MGD-MRK-10710, MGI:1345182, MGI:2444307, MGI:2444355

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory