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H2-Ea-ps Pseudogene Detail
Summary
  • Symbol
    H2-Ea-ps
  • Name
    histocompatibility 2, class II antigen E alpha, pseudogene
  • Synonyms
    H-2Ea, Ia3, Ia-3, I-Ealpha
Location &
Maps
more
  • Sequence Map
    Chr17:34342933-34344643 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    31 experiments
  • Sequence Tag for
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95900
pseudogene Chr17:34342912-34347547 (-)
129S1/SvImJ MGP_129S1SvImJ_G0040151
pseudogene Chr17:34352697-34354415 (-)
A/J MGP_AJ_G0040144
pseudogene Chr17:33184744-33186450 (-)
AKR/J MGP_AKRJ_G0040067
pseudogene Chr17:33575579-33577281 (-)
BALB/cJ MGP_BALBcJ_G0040130
pseudogene Chr17:33344981-33346699 (-)
C3H/HeJ MGP_C3HHeJ_G0039776
pseudogene Chr17:33931964-33934530 (-)
C57BL/6NJ MGP_C57BL6NJ_G0040720
pseudogene Chr17:35637011-35638719 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0037187
pseudogene Chr17:31153519-31155221 (-)
CAST/EiJ MGP_CASTEiJ_G0038867
pseudogene Chr17:34018073-34019770 (-)
CBA/J MGP_CBAJ_G0039742
pseudogene Chr17:37106241-37107947 (-)
DBA/2J MGP_DBA2J_G0039940
pseudogene Chr17:32529408-32531106 (-)
FVB/NJ MGP_FVBNJ_G0039901
pseudogene Chr17:32386963-32388662 (-)
LP/J MGP_LPJ_G0039985
pseudogene Chr17:34611942-34613711 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0039889
pseudogene Chr17:36076074-36077786 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0040818
pseudogene Chr17:33905091-33906793 (-)
PWK/PhJ MGP_PWKPhJ_G0038558
pseudogene Chr17:31468330-31470083 (-)
SPRET/EiJ MGP_SPRETEiJ_G0038262
pseudogene Chr17:31867337-31869051 (-)
WSB/EiJ MGP_WSBEiJ_G0039091
pseudogene Chr17:33946739-33948434 (-)



Homology
more
  • Human Ortholog
    HLA-DRA, major histocompatibility complex, class II, DR alpha
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HLA-DRA, major histocompatibility complex, class II, DR alpha
    Orthology source: HomoloGene
  • Synonyms
    HLA-DRA1
  • Links
    NCBI Gene ID: 3122
    neXtProt AC: NX_P01903
    UniProt: P01903

  • Chr Location
    6p21.32; chr6:32439842-32445046 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from multigenic genotypes
    34 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036322 Ensembl Gene Model | MGI Sequence Detail 1711 C57BL/6J ±  kb
transcript ENSMUST00000134042 Ensembl | MGI Sequence Detail 686 Not Applicable  
polypeptide P14439 UniProt | EBI | MGI Sequence Detail 255 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR014745 MHC class II, alpha/beta chain, N-terminal
    IPR001003 MHC class II, alpha chain, N-terminal
Molecular
Reagents
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  • All nucleic 65
    Genomic 52
    cDNA 8
    Primer pair 2
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10383, MGD-MRK-10496, MGD-MRK-11046, MGD-MRK-11051, MGI:2146825
References
more
  • Summaries
    All 103
    Diseases 2
    Gene Ontology 4
    Phenotypes 34
  • Earliest
    J:5527 Shreffler DC, et al., The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization. Adv Immunol. 1975;20:125-95
  • Latest
    J:265674 Jansson L, et al., Immunotherapy With Apitopes Blocks the Immune Response to TSH Receptor in HLA-DR Transgenic Mice. Endocrinology. 2018 Sep 1;159(9):3446-3457

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory