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H2-Ea Pseudogene Detail
Summary
  • Symbol
    H2-Ea
  • Name
    histocompatibility 2, class II antigen E alpha
  • Synonyms
    H-2Ea, H2-Ea-ps, Ia3, Ia-3, I-Ealpha
  • Feature Type
    polymorphic pseudogene
  • IDs
    MGI:95900
    NCBI Gene: 100504404
  • Gene Overview
    MyGene.info: HLA-DRA
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34341959-34344645 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    31 experiments
  • Sequence Tag for
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95900
polymorphic pseudogene Chr17:34341959-34347547 (-)
129S1/SvImJ MGP_129S1SvImJ_G0040151
pseudogene Chr17:34352697-34354415 (-)
A/J MGP_AJ_G0040144
pseudogene Chr17:33184744-33186450 (-)
AKR/J MGP_AKRJ_G0040067
pseudogene Chr17:33575579-33577281 (-)
BALB/cJ MGP_BALBcJ_G0040130
pseudogene Chr17:33344981-33346699 (-)
C3H/HeJ MGP_C3HHeJ_G0039776
pseudogene Chr17:33931964-33934530 (-)
C57BL/6NJ MGP_C57BL6NJ_G0040720
pseudogene Chr17:35637011-35638719 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0037187
pseudogene Chr17:31153519-31155221 (-)
CAST/EiJ MGP_CASTEiJ_G0038867
pseudogene Chr17:34018073-34019770 (-)
CBA/J MGP_CBAJ_G0039742
pseudogene Chr17:37106241-37107947 (-)
DBA/2J MGP_DBA2J_G0039940
pseudogene Chr17:32529408-32531106 (-)
FVB/NJ MGP_FVBNJ_G0039901
pseudogene Chr17:32386963-32388662 (-)
LP/J MGP_LPJ_G0039985
pseudogene Chr17:34611942-34613711 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0039889
pseudogene Chr17:36076074-36077786 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0040818
pseudogene Chr17:33905091-33906793 (-)
PWK/PhJ MGP_PWKPhJ_G0038558
pseudogene Chr17:31468330-31470083 (-)
SPRET/EiJ MGP_SPRETEiJ_G0038262
pseudogene Chr17:31867337-31869051 (-)
WSB/EiJ MGP_WSBEiJ_G0039091
pseudogene Chr17:33946739-33948434 (-)



Homology
more
  • Human Ortholog
    HLA-DRA, major histocompatibility complex, class II, DR alpha
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HLA-DRA, major histocompatibility complex, class II, DR alpha
    Orthology source: HomoloGene
  • Synonyms
    HLA-DRA1
  • Links
    NCBI Gene ID: 3122
    neXtProt AC: NX_P01903
    UniProt: P01903

  • Chr Location
    6p21.32; chr6:32439842-32445046 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from multigenic genotypes
    35 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036322 Ensembl Gene Model | MGI Sequence Detail 2687 C57BL/6J ±  kb
transcript ENSMUST00000134042 Ensembl | MGI Sequence Detail 687 Not Applicable  
polypeptide ENSMUSP00000158275 Ensembl | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    Genomic 52
    cDNA 8
    Primer pair 2
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10383, MGD-MRK-10496, MGD-MRK-11046, MGD-MRK-11051, MGI:2146825
References
more
  • Summaries
    All 106
    Diseases 2
    Gene Ontology 4
    Phenotypes 35
  • Earliest
    J:5527 Shreffler DC, et al., The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization. Adv Immunol. 1975;20:125-95
  • Latest
    J:265674 Jansson L, et al., Immunotherapy With Apitopes Blocks the Immune Response to TSH Receptor in HLA-DR Transgenic Mice. Endocrinology. 2018 Sep 1;159(9):3446-3457

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory