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Gene Detail
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Synonyms 5530400H20Rik, A930027G11Rik, C130027O20Rik, Galphas, G alpha s, Gnas1, Gnasxl, Gsa, Gs alpha, Gs-alpha, Nesp, Nesp55, Nespl, neuroendocrine-specific Golgi protein p55 isoform 1, Oedsml, P1, P2, P3, XLalphas
Feature Type protein coding gene
Genetic Map
Chromosome 2
97.89 cM, cytoband E1-H3
Detailed Genetic Map ± 1 cM

Mapping data(40)
Sequence Map
Chr2:174284320-174346744 bp, + strand
From VEGA annotation of GRCm38

  62425 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:131319  Vertebrate Homology Class
1 mouse

Gene Tree: Gnas

All alleles(30) : Targeted(19) Gene trapped(10) Chemically induced(1)
Mutant homozygotes stop developing normally by embryonic day 10.5 and die prenatally. On some backgrounds heterozygotes show imprinted phenotypes, including differences in body shape/weight, locomotor activity, metabolism, and developmental anomalies.
Human Diseases Modeled Using Mouse Gnas (3)    Alleles Annotated to Human Diseases(2)    Phenotype Images(6)
Gene Ontology
All GO classifications: (50 annotations)
Process adenylate cyclase-activating dopamine receptor signaling pathway, adenylate cyclase-activating G-protein coupled receptor signaling pathway, ...
Component cell projection, cytoplasmic vesicle, ...
Function G-protein beta/gamma-subunit complex binding, GTPase activity, ...
External Resources: FuncBase
Literature Summary: (19 records)
Data Summary: Results (77)    Tissues (58)    Images (24)
Theiler Stages: 1, 2, 3, 4, 16, 17, 18, 19, 21, 23, 26, 28
Assay TypeResults
RNA in situ 63
cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress
All nucleic(51) Genomic(4) cDNA(40) Primer pair(5) Other(2)
Microarray probesets(7)
Other database
VEGA Gene ModelOTTMUSG00000016388 (Evidence)
Ensembl Gene ModelENSMUSG00000027523 (Evidence)
Entrez Gene14683 (Evidence)
DFCITC1573765, TC1581072, TC1582546, TC1588759, TC1591666, TC1592101, TC1593648, TC1595635, TC1596835, TC1597815, TC1611620, TC1621339, TC1721323, TC1761105
DoTSDT.101177440, DT.101329047, DT.101334873, DT.101402523, DT.101402629, DT.101402740, DT.101402796, DT.101718171, DT.102537340, DT.103574781, DT.103574784, DT.110673614, DT.110673770, DT.40134545, DT.55165638, DT.91316474, DT.91321509, DT.91421461, DT.94153713, DT.94280944, DT.94376570, DT.94376603, DT.98132250, DT.99865656
NIA Mouse Gene IndexU088428
Consensus CDS ProjectCCDS17149.1, CCDS17150.1, CCDS17151.1, CCDS38354.1, CCDS38355.1, CCDS38356.1, CCDS38357.1, CCDS50817.1
International Mouse Knockout Project StatusGnas
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016388 VEGA Gene Model | MGI Sequence Detail 62425 C57BL/6J ±  kb
transcript OTTMUST00000039462 VEGA | MGI Sequence Detail 3519 Not Applicable 
polypeptide OTTMUSP00000017632 VEGA | MGI Sequence Detail 1133 Not Applicable 

For the selected sequences
All sequences(225) RefSeq(35) UniProt(11)
Polymorphisms All PCR and RFLP(6) : PCR(2) RFLP(4) SNPs within 2kb(304 from dbSNP Build 137)
InterPro IPR000367 G-protein alpha subunit, group S
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR009434 Neuroendocrine-specific golgi P55
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
References (Earliest) J:8410 Sullivan KA, et al., Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91
(Latest) J:204616 Nakashima A, et al., Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons. Cell. 2013 Sep 12;154(6):1314-25
All references(167)
accession IDs
MGD-MRK-10189, MGD-MRK-10282, MGI:1336163, MGI:1336215, MGI:1918608, MGI:1925540, MGI:1931436, MGI:2183280, MGI:2442318

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.17
The Jackson Laboratory