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Gnas Gene Detail
Summary
  • Symbol
    Gnas
  • Name
    GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
  • Synonyms
    Galphas, G alpha s, Gnas1, Gnasxl, Gsa, Gs alpha, Gs-alpha, Nesp, Nesp55, Nespl, neuroendocrine-specific Golgi protein p55 isoform 1, Oedsml, P1, P2, P3, SCG6, XLalphas
  • Feature Type
    protein coding gene
  • IDs
    MGI:95777
    NCBI Gene: 14683
  • Gene Overview
    MyGene.info: GNAS
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr2:174284320-174346744 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      62425 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 97.89 cM, cytoband E1-H3
  • Mapping Data
    40 experiments
Homology
more
  • Human Ortholog
    GNAS, GNAS complex locus
  • Vertebrate Orthologs
    10
  • HomoloGene
    Vertebrate Homology Class 55534
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GNAS
  • Gene Tree
    Gnas
Human Diseases
more
  • Diseases
    4 with Gnas mouse models; 5 with human GNAS associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    171 phenotypes from 18 alleles in 30 genetic backgrounds
    21 phenotypes from multigenic genotypes
    6 images
    78 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant homozygotes stop developing normally by embryonic day 10.5 and die prenatally. On some backgrounds heterozygotes show imprinted phenotypes, including differences in body shape/weight, locomotor activity, metabolism, and developmental anomalies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    106
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    78
  • Tissues
    57
  • cDNA Data
    36
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016388 VEGA Gene Model | MGI Sequence Detail 62425 C57BL/6J ±  kb
    transcript OTTMUST00000039462 VEGA | MGI Sequence Detail 3519 Not Applicable  
    polypeptide OTTMUSP00000017632 VEGA | MGI Sequence Detail 1133 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      283 from dbSNP Build 142
    • PCR
      2
    • RFLP
      4
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000029511 GNAS gene translation product
      (term hierarchy)
    • InterPro Domains
      IPR000367 G-protein alpha subunit, group S
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
      IPR009434 Neuroendocrine secretory protein 55
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 4
      cDNA 44
      Primer pair 6
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-10189, MGD-MRK-10282, MGI:1336163, MGI:1336215, MGI:1918608, MGI:1925540, MGI:1931436, MGI:2183280, MGI:2442318
    References
    more
    • Summaries
      All 203
      Developmental Gene Expression 25
      Diseases 5
      Gene Ontology 22
      Phenotypes 78
    • Earliest
      J:8410 Sullivan KA, et al., Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91
    • Latest
      J:258122 Kaucka M, et al., Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage. Elife. 2017 Apr 17;6(None):None
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory