Gnas
Gene Detail

Symbol

Name
ID

Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
MGI:95777

Synonyms

5530400H20Rik, A930027G11Rik, C130027O20Rik, Galphas, G alpha s, Gnas1, Gnasxl, Gsa, Gs alpha, Gs-alpha, Nesp, Nesp55, Nespl, neuroendocrine-specific Golgi protein p55 isoform 1, Oedsml, P1, P2, P3, XLalphas

Feature Type

protein coding gene

Genetic Map

Chromosome 2
97.89 cM, cytoband E1-H3
Detailed Genetic Map ± 1 cM


Mapping data(40)

Sequence Map

Chr2:174284320-174346744 bp, + strand From VEGA annotation of GRCm38   62425 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:55534  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gnas

Human
homologs

Human Homolog		GNAS, GNAS complex locus
NCBI Gene ID		2778
neXtProt AC		NX_O95467, NX_P63092, NX_P84996, NX_Q5JWF2
Human Synonyms		AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH
Human Chr (Location)		20q13.3; chr20:58839740-58911195 (+)  GRCh38
Disease Associations		(8) Diseases Associated with Human GNAS

Mutations,
alleles, and
phenotypes

All mutations/alleles(32) : Chemically induced (ENU)(1) Gene trapped(10) Targeted(20) Transgenic(1)
Genomic Mutations involving Gnas (1)
Incidental mutations (data from Mutagenetix , APF )
 

Mutant homozygotes stop developing normally by embryonic day 10.5 and die prenatally. On some backgrounds heterozygotes show imprinted phenotypes, including differences in body shape/weight, locomotor activity, metabolism, and developmental anomalies.

 
Human Diseases Modeled in Mice Using Gnas (2)    Mutations Annotated to Human Diseases (3)    Phenotype Images(6)

Interactions

Gnas interacts with 241 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (120 annotations)

Process	adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-activating dopamine receptor signaling pathway, ...
Component	cell projection, cytoplasm, ...
Function	alpha-tubulin binding, beta-2 adrenergic receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)

Data Summary: Results (74)    Tissues (56)    Images (24)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	63
RT-PCR	11

cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(51) Genomic(4) cDNA(40) Primer pair(5) Other(2)
Microarray probesets(7)

Other database
links

VEGA Gene Model	OTTMUSG00000016388 (Evidence)
Ensembl Gene Model	ENSMUSG00000027523 (Evidence)
Entrez Gene	14683 (Evidence)
DFCI	TC1573765, TC1581072, TC1582546, TC1588759, TC1591666, TC1592101, TC1593648, TC1595635, TC1596835, TC1597815, TC1611620, TC1621339, TC1721323, TC1761105
DoTS	DT.101177440, DT.101329047, DT.101334873, DT.101402523, DT.101402629, DT.101402740, DT.101402796, DT.101718171, DT.102537340, DT.103574781, DT.103574784, DT.110673614, DT.110673770, DT.40134545, DT.55165638, DT.91316474, DT.91321509, DT.91421461, DT.94153713, DT.94280944, DT.94376570, DT.94376603, DT.98132250, DT.99865656
NIA Mouse Gene Index	U088428
Consensus CDS Project	CCDS17149.1, CCDS17150.1, CCDS17151.1, CCDS38354.1, CCDS38355.1, CCDS38356.1, CCDS38357.1, CCDS50817.1
International Mouse Knockout Project Status	Gnas

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016388	VEGA Gene Model | MGI Sequence Detail	62425	C57BL/6J
transcript	OTTMUST00000039462	VEGA | MGI Sequence Detail	3519	Not Applicable
polypeptide	OTTMUSP00000017632	VEGA | MGI Sequence Detail	1133	Not Applicable

All sequences(230) RefSeq(35) UniProt(12)

Polymorphisms

All PCR and RFLP(6) : PCR(2) RFLP(4) SNPs within 2kb(304 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000367	G-protein alpha subunit, group S
InterPro	IPR011025	G protein alpha subunit, helical insertion
InterPro	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro	IPR009434	Neuroendocrine-specific golgi P55
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase

References

(Earliest) J:8410 Sullivan KA, et al., Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91
(Latest) J:213680 Pellicelli M, et al., The PTH-Galphas-protein kinase A cascade controls alphaNAC localization to regulate bone mass. Mol Cell Biol. 2014 May;34(9):1622-33
All references(172)
Disease annotation references (1)

Other
accession IDs

MGD-MRK-10189, MGD-MRK-10282, MGI:1336163, MGI:1336215, MGI:1918608, MGI:1925540, MGI:1931436, MGI:2183280, MGI:2442318