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Gnas Gene Detail
Summary
  • Symbol
    Gnas
  • Name
    GNAS complex locus
  • Synonyms
    Galphas, G alpha s, Gnas1, Gnasxl, Gsa, Gs alpha, Gs-alpha, Nesp, Nesp55, Nespl, neuroendocrine-specific Golgi protein p55 isoform 1, Oedsml, P1, P2, P3, SCG6, XLalphas
  • Feature Type
    protein coding gene
  • IDs
    MGI:95777
    NCBI Gene: 14683
  • Alliance
  • Transcription Start Sites
    63 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:174126113-174188537 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 97.89 cM, cytoband E1-H3
  • Mapping Data
    40 experiments
Strain
Comparison
more
  • SNPs within 2kb
    277 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95777
protein coding gene Chr2:174126113-174188537 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026964
protein coding gene Chr2:180630364-180692546 (+)
A/J MGP_AJ_G0026931
protein coding gene Chr2:173019243-173082750 (+)
AKR/J MGP_AKRJ_G0026902
protein coding gene Chr2:178234685-178297274 (+)
BALB/cJ MGP_BALBcJ_G0026940
protein coding gene Chr2:173409894-173473065 (+)
C3H/HeJ MGP_C3HHeJ_G0026682
protein coding gene Chr2:178612042-178677336 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027387
protein coding gene Chr2:185827607-185897724 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024756
protein coding gene Chr2:166260882-166324606 (+)
CAST/EiJ MGP_CASTEiJ_G0026141
protein coding gene Chr2:179339358-179404333 (+)
CBA/J MGP_CBAJ_G0026659
protein coding gene Chr2:192746722-192811366 (+)
DBA/2J MGP_DBA2J_G0026797
protein coding gene Chr2:172119457-172184108 (+)
FVB/NJ MGP_FVBNJ_G0026763
protein coding gene Chr2:170742405-170805441 (+)
LP/J MGP_LPJ_G0026898
protein coding gene Chr2:180540747-180606553 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026782
protein coding gene Chr2:195644796-195711054 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027444
protein coding gene Chr2:178258034-178322320 (+)
PWK/PhJ MGP_PWKPhJ_G0025877
protein coding gene Chr2:171927066-171991286 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025677
protein coding gene Chr2:177300546-177364210 (+)
WSB/EiJ MGP_WSBEiJ_G0026213
protein coding gene Chr2:179221635-179288390 (+)



Homology
more
  • Human Ortholog
    GNAS, GNAS complex locus
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources

Human Diseases
more
  • Diseases
    3 with Gnas mouse models; 10 with human GNAS associations

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 2 models
IDs
View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    201 phenotypes from 17 alleles in 31 genetic backgrounds
    19 phenotypes from multigenic genotypes
    6 images
    119 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant homozygotes stop developing normally by embryonic day 10.5 and die prenatally. On some backgrounds heterozygotes show imprinted phenotypes, including differences in body shape/weight, locomotor activity, metabolism, and developmental anomalies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14683 NCBI Gene Model | MGI Sequence Detail 62425 C57BL/6J ±  kb
    transcript NM_001310083 RefSeq | MGI Sequence Detail 3921 ZRU/MplStud  
    polypeptide Q6R0H7 UniProt | EBI | MGI Sequence Detail 1133 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      19 Sequences
    • Protein Ontology
      PR:000029511 GNAS gene translation product
    • PDB
    • InterPro Domains
      IPR000367 G-protein alpha subunit, group S
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
      IPR009434 Neuroendocrine secretory protein 55
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 4
      cDNA 46
      Primer pair 10
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-10189, MGD-MRK-10282, MGI:1336163, MGI:1336215, MGI:1918608, MGI:1925540, MGI:1931436, MGI:2183280, MGI:2442318
    References
    more
    • Summaries
      All 258
      Developmental Gene Expression 30
      Diseases 4
      Gene Ontology 28
      Phenotypes 119
    • Earliest
      J:8410 Sullivan KA, et al., Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91
    • Latest
      J:337742 Wu VH, et al., The GPCR-Galpha(s)-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure. Nat Immunol. 2023 Jun 12;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory