About   Help   FAQ
Gnas Gene Detail
Summary
  • Symbol
    Gnas
  • Name
    GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
  • Synonyms
    Galphas, G alpha s, Gnas1, Gnasxl, Gsa, Gs alpha, Gs-alpha, Nesp, Nesp55, Nespl, neuroendocrine-specific Golgi protein p55 isoform 1, Oedsml, P1, P2, P3, SCG6, XLalphas
  • Feature Type
    protein coding gene
  • IDs
    MGI:95777
    NCBI Gene: 14683
  • Gene Overview
    MyGene.info: GNAS
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:174284320-174346744 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 97.89 cM, cytoband E1-H3
  • Mapping Data
    40 experiments
Strain
Comparison
more
  • SNPs within 2kb
    283 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95777
 protein coding gene Chr2:174284306-174346744 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026964
 protein coding gene Chr2:180630364-180692546 (+)
A/J MGP_AJ_G0026931
 protein coding gene Chr2:173019243-173082750 (+)
AKR/J MGP_AKRJ_G0026902
 protein coding gene Chr2:178234685-178297274 (+)
BALB/cJ MGP_BALBcJ_G0026940
 protein coding gene Chr2:173409894-173473065 (+)
C3H/HeJ MGP_C3HHeJ_G0026682
 protein coding gene Chr2:178612042-178677336 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027387
 protein coding gene Chr2:185827607-185897724 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024756
 protein coding gene Chr2:166260882-166324606 (+)
CAST/EiJ MGP_CASTEiJ_G0026141
 protein coding gene Chr2:179339358-179404333 (+)
CBA/J MGP_CBAJ_G0026659
 protein coding gene Chr2:192746722-192811366 (+)
DBA/2J MGP_DBA2J_G0026797
 protein coding gene Chr2:172119457-172184108 (+)
FVB/NJ MGP_FVBNJ_G0026763
 protein coding gene Chr2:170742405-170805441 (+)
LP/J MGP_LPJ_G0026898
 protein coding gene Chr2:180540747-180606553 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026782
 protein coding gene Chr2:195644796-195711054 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027444
 protein coding gene Chr2:178258034-178322320 (+)
PWK/PhJ MGP_PWKPhJ_G0025877
 protein coding gene Chr2:171927066-171991286 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025677
 protein coding gene Chr2:177300546-177364210 (+)
WSB/EiJ MGP_WSBEiJ_G0026213
 protein coding gene Chr2:179221635-179288390 (+)



Homology
more
  • Human Ortholog
    GNAS, GNAS complex locus
  • Vertebrate Orthologs
    10
  • HomoloGene
    Vertebrate Homology Class 55534
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GNAS
  • Gene Tree
    Gnas
Human Diseases
more
  • Diseases
    4 with Gnas mouse models; 5 with human GNAS associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
 View 2 models
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    173 phenotypes from 18 alleles in 30 genetic backgrounds
    22 phenotypes from multigenic genotypes
    6 images
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant homozygotes stop developing normally by embryonic day 10.5 and die prenatally. On some backgrounds heterozygotes show imprinted phenotypes, including differences in body shape/weight, locomotor activity, metabolism, and developmental anomalies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    127
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    78
  • Tissues
    57
  • cDNA Data
    37
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027523 Ensembl Gene Model | MGI Sequence Detail 62425 C57BL/6J ±  kb
    transcript ENSMUST00000080493 Ensembl | MGI Sequence Detail 3519 Not Applicable  
    polypeptide ENSMUSP00000079341 Ensembl | MGI Sequence Detail 1133 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000029511 GNAS gene translation product
      (term hierarchy)
    • InterPro Domains
      IPR000367 G-protein alpha subunit, group S
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
      IPR009434 Neuroendocrine secretory protein 55
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 4
      cDNA 45
      Primer pair 6
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-10189, MGD-MRK-10282, MGI:1336163, MGI:1336215, MGI:1918608, MGI:1925540, MGI:1931436, MGI:2183280, MGI:2442318
    References
    more
    • Summaries
      All 218
      Developmental Gene Expression 26
      Diseases 5
      Gene Ontology 23
      Phenotypes 91
    • Earliest
      J:8410 Sullivan KA, et al., Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91
    • Latest
      J:268740 Patra KC, et al., Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nat Cell Biol. 2018 Jul;20(7):811-822
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    10/08/2019
    MGI 6.14     		The Jackson Laboratory