Gnas
Gene Detail

Symbol Name ID

Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus MGI:95777

Synonyms

5530400H20Rik, A930027G11Rik, C130027O20Rik, Galphas, G alpha s, Gnas1, Gnasxl, Gsa, Gs alpha, Gs-alpha, Nesp, Nesp55, Nespl, neuroendocrine-specific Golgi protein p55 isoform 1, Oedsml, P1, P2, P3, XLalphas

Feature Type

protein coding gene

Genetic Map

Chromosome 2

97.89 cM, cytoband E1-H3
Detailed Genetic Map ± 1 cM


Mapping data(40)

Sequence Map

Chr2:174284320-174346744 bp, + strand From VEGA annotation of GRCm38   62425 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Gnas ± 2 cM)

Gene Tree: Gnas

Human ortholog

GNAS GNAS complex locus NCBI Gene ID 2778
Human Synonyms: AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH
Human Chr20:57414795-57486250 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human GNAS (9)

Alleles and phenotypes

All alleles(30) : Targeted(19) Gene trapped(10) Chemically induced(1)
 

Mutant homozygotes stop developing normally by embryonic day 10.5 and die prenatally. On some backgrounds heterozygotes show imprinted phenotypes, including differences in body shape/weight, locomotor activity, metabolism, and developmental anomalies.

 
Human Diseases Modeled Using Mouse Gnas (3)    Alleles Annotated to Human Diseases(2)    Phenotype Images(6)

Gene Ontology (GO) classifications

All GO classifications: (82 annotations)

Process	adenylate cyclase-activating dopamine receptor signaling pathway, adenylate cyclase-activating G-protein coupled receptor signaling pathway, ...
Component	cell projection, cytoplasm, ...
Function	alpha-tubulin binding, beta-2 adrenergic receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (77)    Tissues (58)    Images (24)
Theiler Stages: 1, 2, 3, 4, 16, 17, 18, 19, 21, 23, 26, 28

Assay Type	Results
RNA in situ	63
RT-PCR	14

cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(51) Genomic(4) cDNA(40) Primer pair(5) Other(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000016388 (Evidence)
Ensembl Gene Model	ENSMUSG00000027523 (Evidence)
Entrez Gene	14683 (Evidence)
DFCI	TC1573765, TC1581072, TC1582546, TC1588759, TC1591666, TC1592101, TC1593648, TC1595635, TC1596835, TC1597815, TC1611620, TC1621339, TC1721323, TC1761105
DoTS	DT.101177440, DT.101329047, DT.101334873, DT.101402523, DT.101402629, DT.101402740, DT.101402796, DT.101718171, DT.102537340, DT.103574781, DT.103574784, DT.110673614, DT.110673770, DT.40134545, DT.55165638, DT.91316474, DT.91321509, DT.91421461, DT.94153713, DT.94280944, DT.94376570, DT.94376603, DT.98132250, DT.99865656
NIA Mouse Gene Index	U088428
Consensus CDS Project	CCDS17149.1, CCDS17150.1, CCDS17151.1, CCDS38354.1, CCDS38355.1, CCDS38356.1, CCDS38357.1, CCDS50817.1
International Mouse Knockout Project Status	Gnas

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016388	VEGA Gene Model | MGI Sequence Detail	62425	C57BL/6J
transcript	OTTMUST00000039462	VEGA | MGI Sequence Detail	3519	Not Applicable
polypeptide	OTTMUSP00000017632	VEGA | MGI Sequence Detail	1133	Not Applicable

All sequences(210) RefSeq(18) UniProt(13)

Polymorphisms

All PCR and RFLP(6) : PCR(2) RFLP(4) SNPs(251 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000367	G-protein alpha subunit, group S
InterPro	IPR011025	G protein alpha subunit, helical insertion
InterPro	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro	IPR009434	Neuroendocrine-specific golgi P55

References

(Earliest) J:8410 Sullivan KA, et al., Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91
(Latest) J:189194 Chen M, et al., Gsalpha deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsalpha mutations. Endocrinology. 2012 Sep;153(9):4256-65
All references(160)

Other accession IDs

MGD-MRK-10189, MGD-MRK-10282, MGI:1336163, MGI:1336215, MGI:1918608, MGI:1925540, MGI:1931436, MGI:2183280, MGI:2442318