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Gnas
Gene Detail
Symbol

Name
ID
Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
MGI:95777
Synonyms
5530400H20Rik, A930027G11Rik, C130027O20Rik, Galphas, G alpha s, Gnas1, Gnasxl, Gsa, Gs alpha, Gs-alpha, Nesp, Nesp55, Nespl, neuroendocrine-specific Golgi protein p55 isoform 1, Oedsml, P1, P2, P3, XLalphas
Feature Type
protein coding gene
Genetic Map
Chromosome 2
97.89 cM, cytoband E1-H3
Detailed Genetic Map ± 1 cM


Mapping data(40)
Sequence Map
Chr2:174284320-174346744 bp, + strand
From VEGA annotation of GRCm38

  62425 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55534  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gnas

Human
homologs
Human Homolog GNAS, GNAS complex locus
NCBI Gene ID 2778
neXtProt AC  NX_O95467, NX_P63092, NX_P84996, NX_Q5JWF2
Human Synonyms  AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH
Human Chr (Location)  20q13.3; chr20:58839740-58911195 (+)  GRCh38
Disease Associations  (8) Diseases Associated with Human GNAS
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Chemically induced (ENU)(1) Gene trapped(10) Targeted(19)
Genomic Mutations involving Gnas (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant homozygotes stop developing normally by embryonic day 10.5 and die prenatally. On some backgrounds heterozygotes show imprinted phenotypes, including differences in body shape/weight, locomotor activity, metabolism, and developmental anomalies.
 
Human Diseases Modeled Using Mouse Gnas (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(6)
Interactions
Gnas interacts with 241 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (20 records)
Data Summary: Results (74)    Tissues (56)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 63
RT-PCR 11
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) Genomic(4) cDNA(40) Primer pair(5) Other(2)
Microarray probesets(7)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016388 VEGA Gene Model | MGI Sequence Detail 62425 C57BL/6J ±  kb
transcript OTTMUST00000039462 VEGA | MGI Sequence Detail 3519 Not Applicable 
polypeptide OTTMUSP00000017632 VEGA | MGI Sequence Detail 1133 Not Applicable 

For the selected sequences
All sequences(234) RefSeq(35) UniProt(20)
Polymorphisms
All PCR and RFLP(6) : PCR(2) RFLP(4) SNPs within 2kb(304 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000367 G-protein alpha subunit, group S
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR009434 Neuroendocrine-specific golgi P55
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
References
(Earliest) J:8410 Sullivan KA, et al., Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91
(Latest) J:213680 Pellicelli M, et al., The PTH-Galphas-protein kinase A cascade controls alphaNAC localization to regulate bone mass. Mol Cell Biol. 2014 May;34(9):1622-33
All references(172)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10189, MGD-MRK-10282, MGI:1336163, MGI:1336215, MGI:1918608, MGI:1925540, MGI:1931436, MGI:2183280, MGI:2442318

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory