Symbol
Name
ID

Gnas
GNAS complex locus
MGI:95777

Phenotype annotations related to growth/size/body

Darker colors indicate more annotations

Human Phenotypes	Short neck	Short stature	Increased waist to hip ratio	Obesity	Truncal obesity
Disease(s) Associated with GNAS	Short neck	Short stature	Increased waist to hip ratio	Obesity	Truncal obesity
ACTH-independent macronodular adrenal hyperplasia 1
Albright's hereditary osteodystrophy
obesity
pseudohypoparathyroidism
pseudohypoparathyroidism type IB
pseudopseudohypoparathyroidism

Mouse Phenotypes

decreased body fat mass

abnormal incisor morphology

palate bone hypoplasia

absent nasal capsule

palatal shelves fail to meet at midline

round face

complete cleft palate

abnormal tongue morphology

protruding tongue

abnormal nasal septum cartilage morphology

short snout

abnormal outer ear morphology

increased pancreas weight

decreased birth weight

increased birth weight

decreased birth body size

increased birth body size

decreased body mass index

increased body mass index

decreased lean body mass

increased lean body mass

decreased body weight

slow postnatal weight gain

obese

abnormal body size

decreased body length

abnormal body weight

decreased susceptibility to diet-induced obesity

decreased body size

postnatal growth retardation

increased liver weight

Availability

Mouse Genotype

Gnas^Oedsml/Gnas⁺

Gnas^tm1Gwa/Gnas⁺

Gnas^tm1Kel/Gnas⁺

Gnas^tm1Lsw/Gnas⁺

Gnas^tm2Jop/Gnas⁺

Gnas^tm3Jop/Gnas⁺

Gnas^tm3Kel/Gnas⁺

Gnas^tm4Lsw/Gnas⁺

Gnas^tm5.1Lsw/Gnas^tm5.1Lsw
Tg(Alb1-cre)1Dlr/? (conditional)

Gnas^tm5.1Lsw/Gnas^tm5.1Lsw
Tg(Fabp4-cre)1Abel/0 (conditional)

Gnas^tm5.1Lsw/Gnas^tm5.1Lsw
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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