Tg(Slc5a2-cre)1Tauc
Transgene Detail

Summary

• Symbol: Tg(Slc5a2-cre)1Tauc
• Name: transgene insertion 1, Michel Tauc
• MGI ID: MGI:3694735
• Synonyms: iL1-sglt2-Cre, mSglt2 5pr-mut-Cre
• Transgene: Tg(Slc5a2-cre)1Tauc Location: unknown
• Alliance: Tg(Slc5a2-cre)1Tauc page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Slc5a2-cre)1Tauc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Slc5a2

• Mutation details: The transgene expresses Cre recombinase under control of the promoter region of the gene encoding solute carrier family 5 (sodium/glucose cotransporter), member 2, including 1952 bp of 5'-flanking sequence, the first exon (containing a mutated translation initiation codon), first intron and 23 bp of the second exon. X-gal staining of multiple tissues from mice doubly transgenic for this transgene and for the E. coli beta-galactosidase gene (lacZ) preceded by a loxP-flanked stop sequence (knocked into the Gt(ROSA)26Sor locus) demonstrated beta-galactosidase activity only in the kidney. Immunohistochemical analysis of X-gal-stained kidney cryostat sections for markers specific to different regions of the nephron showed colocalization of X-gal staining only with anti-megalin antibody, which identifies the proximal tubules. (J:111666)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc5a2 (species not specified) Summary of all recombinase alleles driven by Slc5a2. Comparative matrix view of recombinase activities

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:111666 Rubera I, et al., Specific Cre/Lox recombination in the mouse proximal tubule. J Am Soc Nephrol. 2004 Aug;15(8):2050-6
• All: 22 reference(s)