Gnastm1Gwa
Targeted Allele Detail
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Symbol: |
Gnastm1Gwa |
Name: |
GNAS complex locus; targeted mutation 1, Gary Wand |
MGI ID: |
MGI:2152744 |
Synonyms: |
GnasE1- |
Gene: |
Gnas Location: Chr2:174126113-174188537 bp, + strand Genetic Position: Chr2, 97.89 cM, cytoband E1-H3
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Alliance: |
Gnastm1Gwa page
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Subcutaneous ossifications in Gnastm1Gwa/Gnas+ mice
Show the 6 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:70175
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced 0.5kb of sequence containing the ATG codon and extending through an NruI site in intron 1. Quantitative immunoblot studies showed protein levels in multiple brain regions of mice heterozygous for this allele were significantly reduced relative to wild-type.
(J:70175)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gnas Mutation: |
53 strains or lines available
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Original: |
J:70175 Wand G, et al., The cAMP-protein kinase A signal transduction pathway modulates ethanol consumption and sedative effects of ethanol. J Neurosci. 2001 Jul 15;21(14):5297-303 |
All: |
7 reference(s) |
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