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Gnastm1Gwa
Targeted Allele Detail
Summary
Symbol: Gnastm1Gwa
Name: GNAS complex locus; targeted mutation 1, Gary Wand
MGI ID: MGI:2152744
Synonyms: GnasE1-
Gene: Gnas  Location: Chr2:174126113-174188537 bp, + strand  Genetic Position: Chr2, 97.89 cM, cytoband E1-H3
Alliance: Gnastm1Gwa page
Subcutaneous ossifications in Gnastm1Gwa/Gnas+ mice

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70175
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 0.5kb of sequence containing the ATG codon and extending through an NruI site in intron 1. Quantitative immunoblot studies showed protein levels in multiple brain regions of mice heterozygous for this allele were significantly reduced relative to wild-type. (J:70175)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnas Mutation:  53 strains or lines available
References
Original:  J:70175 Wand G, et al., The cAMP-protein kinase A signal transduction pathway modulates ethanol consumption and sedative effects of ethanol. J Neurosci. 2001 Jul 15;21(14):5297-303
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory