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Flt3
Gene Detail
Symbol

Name
ID
Flt3
FMS-like tyrosine kinase 3
MGI:95559
Synonyms
CD135, Flk2, Flk-2, Flt-3, wmfl
Feature Type
protein coding gene
Genetic Map
Chromosome 5
86.88 cM, cytoband G3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:147330741-147400489 bp, - strand
From VEGA annotation of GRCm38

  69749 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3040  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FLT3
Protein SuperFamily: tyrosine-protein kinase, CSF-1/PDGF receptor type
Gene Tree: Flt3

Human
homologs
FLT3, fms-related tyrosine kinase 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2322
neXtProt AC: NX_P36888

Human Synonyms: CD135, FLK2, FLK-2, STK1

Human Chr (Location): 13q12; chr13:28003274-28100592 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FLT3

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice functionally null for this gene display abnormal lymphopoiesis. Homozygous ENU mutant mice are sensitive to infection by mouse cytomegalovirus.
 
Human Diseases Modeled in Mice Using Flt3 (2)    Mutations Annotated to Human Diseases (3)   
Interactions
Flt3 interacts with 251 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process B cell differentiation, cell differentiation, ...
Component cell surface, cytoplasm, ...
Function ATP binding, cytokine receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (108)    Tissues (52)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 40
Northern blot 21
RT-PCR 47
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN flt3    NEW 
Molecular
reagents
All nucleic(35) Genomic(2) cDNA(25) Primer pair(7) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000020408 (Evidence)
Ensembl Gene Model ENSMUSG00000042817 (Evidence)
Entrez Gene 14255 (Evidence)
UniGene 194
DFCI TC1585904, TC1593503, TC1758221
DoTS DT.40185433, DT.91337294, DT.91416896
NIA Mouse Gene Index U026965
EC 2.7.10.1
Consensus CDS Project CCDS39400.1
International Mouse Phenotyping Consortium Status Flt3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020408 VEGA Gene Model | MGI Sequence Detail 69749 C57BL/6J ±  kb
transcript OTTMUST00000048424 VEGA | MGI Sequence Detail 3657 Not Applicable 
polypeptide OTTMUSP00000022189 VEGA | MGI Sequence Detail 1000 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(6)
Polymorphisms
RFLP(3) : SNPs within 2kb(258 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Protein Ontology PR:000002001 receptor-type tyrosine-protein kinase FLT3
References
(Earliest) J:1614 Rosnet O, et al., Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family. Oncogene. 1991 Sep;6(9):1641-50
(Latest) J:220302 Shih AH, et al., Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia. Cancer Cell. 2015 Apr 13;27(4):502-15
All references(121)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-9827, MGD-MRK-9834, MGD-MRK-9837, MGI:3626335

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory