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Flt3 Gene Detail
Summary
  • Symbol
    Flt3
  • Name
    FMS-like tyrosine kinase 3
  • Synonyms
    CD135, Flk2, Flk-2, Flt-3, wmfl
  • Feature Type
    protein coding gene
  • IDs
    MGI:95559
    NCBI Gene: 14255
  • Gene Overview
    MyGene.info: FLT3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:147330741-147400489 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      69749 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 86.88 cM, cytoband G3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FLT3, fms related tyrosine kinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FLT3, fms related tyrosine kinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD135, FLK2, FLK-2, STK1
  • Links
    NCBI Gene ID: 2322
    neXtProt AC: NX_P36888
    UniProt: P36888

  • Chr Location
    13q12.2; chr13:28003274-28100592 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Flt3 mouse models; 2 with human FLT3 associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 6 alleles in 7 genetic backgrounds
    21 phenotypes from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice functionally null for this gene display abnormal lymphopoiesis. Homozygous ENU mutant mice are sensitive to infection by mouse cytomegalovirus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020408 VEGA Gene Model | MGI Sequence Detail 69749 C57BL/6J ±  kb
    transcript OTTMUST00000048424 VEGA | MGI Sequence Detail 3657 Not Applicable  
    polypeptide OTTMUSP00000022189 VEGA | MGI Sequence Detail 1000 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      254 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 2
      cDNA 26
      Primer pair 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9827, MGD-MRK-9834, MGD-MRK-9837, MGI:3626335
    References
    more
    • Summaries
      All 182
      Developmental Gene Expression 17
      Diseases 3
      Gene Ontology 28
      Phenotypes 75
    • Earliest
      J:1614 Rosnet O, et al., Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family. Oncogene. 1991 Sep;6(9):1641-50
    • Latest
      J:265466 Brunetti L, et al., Mutant NPM1 Maintains the Leukemic State through HOX Expression. Cancer Cell. 2018 Sep 10;34(3):499-512.e9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory