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Flt3 Gene Detail
Summary
  • Symbol
    Flt3
  • Name
    FMS-like tyrosine kinase 3
  • Synonyms
    CD135, Flk2, Flk-2, Flt-3, wmfl
  • Feature Type
    protein coding gene
  • IDs
    MGI:95559
    NCBI Gene: 14255
  • Gene Overview
    MyGene.info: FLT3
Location & Maps
more
  • Sequence Map
    Chr5:147330741-147400489 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      69749 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 86.88 cM, cytoband G3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FLT3, fms related tyrosine kinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FLT3, fms related tyrosine kinase 3
    Orthology source: HomoloGene
  • Synonyms
    CD135, FLK2, FLK-2, STK1
  • Links
    NCBI Gene ID: 2322
    neXtProt AC: NX_P36888

  • Chr Location
    13q12; chr13:28003274-28100592 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Flt3 mouse models; 1 with human FLT3 associations

Human Disease Mouse Models
       Juvenile Myelomonocytic Leukemia; JMML   OMIM: 607785 View 2 models
Leukemia, Acute Myeloid; AML   OMIM: 601626 View 4 models
       Leukemia, Acute Lymphoblastic; ALL   OMIM: 613065
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 6 alleles in 7 genetic backgrounds
    21 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    1
  • Targeted
    6
  • Incidental Mutations
Mice functionally null for this gene display abnormal lymphopoiesis. Homozygous ENU mutant mice are sensitive to infection by mouse cytomegalovirus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020408 VEGA Gene Model | MGI Sequence Detail 69749 C57BL/6J ±  kb
transcript OTTMUST00000048424 VEGA | MGI Sequence Detail 3657 Not Applicable  
polypeptide OTTMUSP00000022189 VEGA | MGI Sequence Detail 1000 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    254 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000002001 receptor-type tyrosine-protein kinase FLT3
  • EC
  • InterPro Domains
    IPR013151 Immunoglobulin
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR030118 Receptor-type tyrosine-protein kinase FLT3
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Molecular
Reagents
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  • All nucleic 35
    Genomic 2
    cDNA 25
    Primer pair 7
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-9827, MGD-MRK-9834, MGD-MRK-9837, MGI:3626335
References
more
  • Summaries
    All 126
    Developmental Gene Expression 15
    Diseases 8
    Gene Ontology 26
    Phenotypes 58
  • Earliest
    J:1614 Rosnet O, et al., Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family. Oncogene. 1991 Sep;6(9):1641-50
  • Latest
    J:232928 Lau CM, et al., Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses. J Exp Med. 2016 Mar 7;213(3):415-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory