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Flt3
Gene Detail
 Symbol
Name
ID
Flt3
FMS-like tyrosine kinase 3
MGI:95559
Synonyms CD135, Flk2, Flk-2, Flt-3, wmfl
Feature Type protein coding gene
Genetic Map
Chromosome 5
86.88 cM, cytoband G3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:147330741-147400489 bp, - strand
From VEGA annotation of GRCm38

  69749 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3040  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, CSF-1/PDGF receptor type
Gene Tree: Flt3

Human
homologs
Human Homolog FLT3, fms-related tyrosine kinase 3
NCBI Gene ID 2322
neXtProt AC  NX_P36888
Human Synonyms  CD135, FLK2, FLK-2, STK1
Human Chr (Location)  13q12; chr13:28003274-28100592 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FLT3
Alleles
and
phenotypes
All alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice functionally null for this gene display abnormal lymphopoiesis. Homozygous ENU mutant mice are sensitive to infection by mouse cytomegalovirus.
 
Human Diseases Modeled Using Mouse Flt3 (2)    Alleles Annotated to Human Diseases(3)   
Gene Ontology
(GO)
classifications
All GO classifications: (64 annotations)
Process B cell differentiation, cellular response to cytokine stimulus, ...
Component cell surface, cytoplasm, ...
Function ATP binding, cytokine receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (109)    Tissues (51)    Images (14)
Theiler Stages: 4, 13, 14, 15, 19, 20, 22, 23, 24, 28
Assay TypeResults
RNA in situ 40
Northern blot 21
RT-PCR 48
cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(35) Genomic(2) cDNA(25) Primer pair(7) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000020408 (Evidence)
Ensembl Gene ModelENSMUSG00000042817 (Evidence)
Entrez Gene14255 (Evidence)
UniGene194
DFCITC1585904, TC1593503, TC1758221
DoTSDT.40185433, DT.91337294, DT.91416896
NIA Mouse Gene IndexU026965
EC2.7.10.1
Consensus CDS ProjectCCDS39400.1
International Mouse Knockout Project StatusFlt3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020408 VEGA Gene Model | MGI Sequence Detail 69749 C57BL/6J ±  kb
transcript OTTMUST00000048424 VEGA | MGI Sequence Detail 3657 Not Applicable 
polypeptide OTTMUSP00000022189 VEGA | MGI Sequence Detail 1000 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(6)
Polymorphisms RFLP(3) : SNPs within 2kb(258 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor
InterPro IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Protein Ontology PR:000002001 receptor-type tyrosine-protein kinase FLT3
References (Earliest) J:1614 Rosnet O, et al., Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family. Oncogene. 1991 Sep;6(9):1641-50
(Latest) J:209877 Jiao J, et al., Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils. J Immunol. 2014 Apr 1;192(7):3374-82
All references(113)
Other
accession IDs
MGD-MRK-9827, MGD-MRK-9834, MGD-MRK-9837, MGI:3626335

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory