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Fgfr1
Gene Detail
Symbol

Name
ID
Fgfr1
fibroblast growth factor receptor 1
MGI:95522
Synonyms
Eask, Fgfr-1, Flt-2, Hspy
Feature Type
protein coding gene
Genetic Map
Chromosome 8
14.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr8:25513654-25575714 bp, + strand
From VEGA annotation of GRCm38

  62061 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FGFR1
Protein SuperFamily: fibroblast growth factor receptor
Gene Tree: Fgfr1

Human
homologs
FGFR1, fibroblast growth factor receptor 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2260
neXtProt AC: NX_P11362

Human Synonyms: BFGFR, bFGF-R-1, CD331, CEK, FGFBR, FGFR-1, FLG, FLT2, FLT-2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD

Human Chr (Location): 8p11.23-p11.22; chr8:38411138-38468834 (-)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human FGFR1

Mutations,
alleles, and
phenotypes
All mutations/alleles(277) : Chemically induced (ENU)(1) Gene trapped(235) Spontaneous(1) Targeted(39) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations die around gastrulation and show defective patterning of axial structures. Hypomorphic and selectively ablated mutations exhibit a wide range of abnormalities affecting diverse structures.
 
Human Diseases Modeled in Mice Using Fgfr1 (2)    Mutations Annotated to Human Diseases (5)    Phenotype Images(1)
Interactions
Fgfr1 interacts with 295 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (104 annotations)
Process angiogenesis, auditory receptor cell development, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function ATP binding, cell adhesion molecule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (218 records)
Data Summary: Results (835)    Tissues (517)    Images (212)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 57
RNA in situ 550
Northern blot 11
RT-PCR 208
RNase protection 9
cDNA source data(235)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FGFR1 ; Xenbase fgfr1 ; ZFIN fgfr1a, fgfr1b    NEW 
Molecular
reagents
All nucleic(282) Genomic(12) cDNA(241) Primer pair(26) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000031031 (Evidence)
Ensembl Gene Model ENSMUSG00000031565 (Evidence)
Entrez Gene 14182 (Evidence)
UniGene 265716
DFCI TC1572910, TC1581404, TC1591736, TC1597670, TC1598177
DoTS DT.101383985, DT.101383993, DT.101741459, DT.103574529, DT.40159403, DT.40174952, DT.91587144, DT.94292118, DT.94292141
NIA Mouse Gene Index U009194
EC 2.7.10.1
PDB 2CKN
Consensus CDS Project CCDS40304.1, CCDS52526.1, CCDS57614.1
International Mouse Phenotyping Consortium Status Fgfr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031031 VEGA Gene Model | MGI Sequence Detail 62061 C57BL/6J ±  kb
transcript OTTMUST00000076866 VEGA | MGI Sequence Detail 4988 Not Applicable 
polypeptide OTTMUSP00000040525 VEGA | MGI Sequence Detail 822 Not Applicable 

For the selected sequences
All sequences(112) RefSeq(20) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(240 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013151 Immunoglobulin
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016248 Tyrosine-protein kinase, fibroblast growth factor receptor
Protein Ontology PR:000001448 basic fibroblast growth factor receptor 1
References
(Earliest) J:29471 Ruta M, et al., Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG). Proc Natl Acad Sci U S A. 1989 Nov;86(22):8722-6
(Latest) J:223062 Palmer K, et al., Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology. Dev Biol. 2015 Jul 30;
All references(419)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-9776, MGD-MRK-9781, MGD-MRK-9833, MGI:2142774, MGI:2662561, MGI:3836280

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory