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Fgfr1 Gene Detail
Summary
  • Symbol
    Fgfr1
  • Name
    fibroblast growth factor receptor 1
  • Synonyms
    Eask, Fgfr-1, FGFR-I, Flt-2, Fr1, Hspy
  • Feature Type
    protein coding gene
  • IDs
    MGI:95522
    NCBI Gene: 14182
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:26008808-26067819 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 14.12 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    234 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95522
protein coding gene Chr8:26003670-26067819 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033481
protein coding gene Chr8:23559098-23626351 (+)
A/J MGP_AJ_G0033461
protein coding gene Chr8:22713243-22775790 (+)
AKR/J MGP_AKRJ_G0033386
protein coding gene Chr8:23460369-23524207 (+)
BALB/cJ MGP_BALBcJ_G0033457
protein coding gene Chr8:22860083-22923016 (+)
C3H/HeJ MGP_C3HHeJ_G0033171
protein coding gene Chr8:23676717-23742627 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033973
protein coding gene Chr8:24525860-24588986 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030923
protein coding gene Chr8:19986550-20049275 (+)
CAST/EiJ MGP_CASTEiJ_G0032497
protein coding gene Chr8:23110536-23179888 (+)
CBA/J MGP_CBAJ_G0033146
protein coding gene Chr8:25475602-25544552 (+)
DBA/2J MGP_DBA2J_G0033301
protein coding gene Chr8:22686163-22747994 (+)
FVB/NJ MGP_FVBNJ_G0033245
protein coding gene Chr8:22490718-22554574 (+)
LP/J MGP_LPJ_G0033390
protein coding gene Chr8:23544433-23613250 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033288
protein coding gene Chr8:24939812-25005362 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033992
protein coding gene Chr8:23398185-23463798 (+)
PWK/PhJ MGP_PWKPhJ_G0032208
protein coding gene Chr8:22319448-22385436 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032042
protein coding gene Chr8:22766955-22830709 (+)
WSB/EiJ MGP_WSBEiJ_G0032613
protein coding gene Chr8:23617285-23683042 (+)



Homology
more
  • Human Ortholog
    FGFR1, fibroblast growth factor receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGFR1, fibroblast growth factor receptor 1
  • Synonyms
    BFGFR, bFGF-R-1, CD331, CEK, ECCL, FGFBR, FGFR-1, FLG, FLT2, FLT-2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD
  • Links
    NCBI Gene ID: 2260
    neXtProt AC: NX_P11362
    UniProt: P11362

  • Chr Location
    8p11.23; chr8:38400215-38468834 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with Fgfr1 mouse models; 15 with human FGFR1 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    257 phenotypes from 35 alleles in 38 genetic backgrounds
    89 phenotypes from multigenic genotypes
    5 images
    225 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die around gastrulation and show defective patterning of axial structures. Hypomorphic and selectively ablated mutations exhibit a wide range of abnormalities affecting diverse structures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14182 NCBI Gene Model | MGI Sequence Detail 59012 C57BL/6J ±  kb
    transcript NM_010206 RefSeq | MGI Sequence Detail 7077 ZRU/MplStud  
    polypeptide P16092 UniProt | EBI | MGI Sequence Detail 822 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 316
      Genomic 12
      cDNA 245
      Primer pair 37
      Other 22

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9776, MGD-MRK-9781, MGD-MRK-9833, MGI:2142774, MGI:2662561, MGI:3836280
    References
    more
    • Summaries
      All 637
      Developmental Gene Expression 299
      Diseases 5
      Gene Ontology 45
      Phenotypes 225
    • Earliest
      J:29471 Ruta M, et al., Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG). Proc Natl Acad Sci U S A. 1989 Nov;86(22):8722-6
    • Latest
      J:345225 Deng Y, et al., Deficiency of endothelial FGFR1 signaling via upregulation of ROCK2 activity aggravated ALI/ARDS. Front Immunol. 2023;14:1041533

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory