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Fgfr1
Gene Detail
 Symbol
Name
ID
Fgfr1
fibroblast growth factor receptor 1
MGI:95522
Synonyms Eask, Fgfr-1, Flt-2, Hspy
Feature Type protein coding gene
Genetic Map
Chromosome 8
14.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr8:25513654-25575714 bp, + strand
From VEGA annotation of GRCm38

  62061 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: fibroblast growth factor receptor
Gene Tree: Fgfr1

Human
homologs
Human Homolog FGFR1, fibroblast growth factor receptor 1
NCBI Gene ID 2260
neXtProt AC  NX_P11362
Human Synonyms  BFGFR, bFGF-R-1, CD331, CEK, FGFBR, FGFR-1, FLG, FLT2, FLT-2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD
Human Chr (Location)  8p11.23-p11.22; chr8:38411138-38468834 (-)  GRCh38
Disease Associations  (5) Diseases Associated with Human FGFR1
Alleles
and
phenotypes
All alleles(273) : Chemically induced (ENU)(1) Gene trapped(235) Spontaneous(1) Targeted(36)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die around gastrulation and show defective patterning of axial structures. Hypomorphic and selectively ablated mutations exhibit a wide range of abnormalities affecting diverse structures.
 
Human Diseases Modeled Using Mouse Fgfr1 (2)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (105 annotations)
Process angiogenesis, auditory receptor cell development, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function ATP binding, cell adhesion molecule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (201 records)
Data Summary: Results (785)    Tissues (468)    Images (172)
Theiler Stages: 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 55
RNA in situ 502
Northern blot 11
RT-PCR 208
RNase protection 9
cDNA source data(234)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(280) Genomic(12) cDNA(240) Primer pair(25) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031031 (Evidence)
Ensembl Gene ModelENSMUSG00000031565 (Evidence)
Entrez Gene14182 (Evidence)
UniGene265716
DFCITC1572910, TC1581404, TC1591736, TC1597670, TC1598177
DoTSDT.101383985, DT.101383993, DT.101741459, DT.103574529, DT.40159403, DT.40174952, DT.91587144, DT.94292118, DT.94292141
NIA Mouse Gene IndexU009194
EC2.7.10.1
PDB2CKN
Consensus CDS ProjectCCDS40304.1, CCDS52526.1, CCDS57614.1
International Mouse Knockout Project StatusFgfr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031031 VEGA Gene Model | MGI Sequence Detail 62061 C57BL/6J ±  kb
transcript OTTMUST00000076866 VEGA | MGI Sequence Detail 4988 Not Applicable 
polypeptide OTTMUSP00000040525 VEGA | MGI Sequence Detail 822 Not Applicable 

For the selected sequences
All sequences(112) RefSeq(20) UniProt(9)
Polymorphisms RFLP(1) : SNPs within 2kb(240 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013151 Immunoglobulin
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016248 Tyrosine-protein kinase, fibroblast growth factor receptor
Protein Ontology PR:000001448 basic fibroblast growth factor receptor 1
References (Earliest) J:29471 Ruta M, et al., Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG). Proc Natl Acad Sci U S A. 1989 Nov;86(22):8722-6
(Latest) J:208254 Brooks LR, et al., Fibroblast growth factor deficiencies impact anxiety-like behavior and the serotonergic system. Behav Brain Res. 2014 May 1;264:74-81
All references(387)
Other
accession IDs
MGD-MRK-9776, MGD-MRK-9781, MGD-MRK-9833, MGI:2142774, MGI:2662561, MGI:3836280

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory