Fgfr1
Gene Detail

Symbol Name ID

Fgfr1 fibroblast growth factor receptor 1 MGI:95522

Synonyms

Eask, Fgfr-1, Flt-2, Hspy

Feature Type

protein coding gene

Genetic Map

Chromosome 8

14.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr8:25513654-25575714 bp, + strand From VEGA annotation of GRCm38   62061 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: fibroblast growth factor receptor
Gene Tree: Fgfr1

Human homologs

Human Homolog		FGFR1, fibroblast growth factor receptor 1
NCBI Gene ID		2260
neXtProt AC		NX_P11362
Human Synonyms		BFGFR, bFGF-R-1, CD331, CEK, FGFBR, FGFR-1, FLG, FLT2, FLT-2, HBGFR, HH2, KAL2, N-SAM, OGD
Human Chr (Location)		8p12; chr8:38268656-38326352 (-)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human FGFR1

Alleles and phenotypes

All alleles(273) : Targeted(36) Gene trapped(235) Spontaneous(1) Chemically induced(1)
 

Homozygotes for targeted null mutations die around gastrulation and show defective patterning of axial structures. Hypomorphic and selectively ablated mutations exhibit a wide range of abnormalities affecting diverse structures.

 
Human Diseases Modeled Using Mouse Fgfr1 (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (102 annotations)

Process	angiogenesis, auditory receptor cell development, ...
Component	cytoplasm, cytoplasmic vesicle, ...
Function	ATP binding, cell adhesion molecule binding, ...

External Resources: FuncBase

Expression

Literature Summary: (194 records)
Data Summary: Results (688)    Tissues (417)    Images (134)
Theiler Stages: 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	458
Northern blot	10
RT-PCR	208
RNase protection	9

cDNA source data(232)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(277) Genomic(12) cDNA(238) Primer pair(24) Other(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000031031 (Evidence)
Ensembl Gene Model	ENSMUSG00000031565 (Evidence)
Entrez Gene	14182 (Evidence)
UniGene	265716
DFCI	TC1572910, TC1581404, TC1591736, TC1597670, TC1598177
DoTS	DT.101383985, DT.101383993, DT.101741459, DT.103574529, DT.40159403, DT.40174952, DT.91587144, DT.94292118, DT.94292141
NIA Mouse Gene Index	U009194
EC	2.7.10.1
PDB	2CKN
Consensus CDS Project	CCDS40304.1, CCDS52526.1, CCDS57614.1
International Mouse Knockout Project Status	Fgfr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031031	VEGA Gene Model | MGI Sequence Detail	62061	C57BL/6J
transcript	OTTMUST00000076866	VEGA | MGI Sequence Detail	4988	Not Applicable
polypeptide	OTTMUSP00000040525	VEGA | MGI Sequence Detail	822	Not Applicable

All sequences(95) RefSeq(6) UniProt(9)

Polymorphisms

RFLP(1) : SNPs(180 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013151	Immunoglobulin
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016248	Tyrosine-protein kinase, fibroblast growth factor receptor
Protein Ontology	PR:000001448	basic fibroblast growth factor receptor 1

References

(Earliest) J:29471 Ruta M, et al., Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG). Proc Natl Acad Sci U S A. 1989 Nov;86(22):8722-6
(Latest) J:194074 Ahn Y, et al., Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93
All references(367)

Other accession IDs

MGD-MRK-9776, MGD-MRK-9781, MGD-MRK-9833, MGI:2142774, MGI:2662561, MGI:3836280