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Fas Gene Detail
Summary
  • Symbol
    Fas
  • Name
    Fas (TNF receptor superfamily member 6)
  • Synonyms
    APO-1, CD95, TNFR6, Tnfrsf6
  • Feature Type
    protein coding gene
  • IDs
    MGI:95484
    NCBI Gene: 14102
Location & Maps
more
  • Sequence Map
    Chr19:34290659-34327770 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37112 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FAS, Fas cell surface death receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FAS, Fas cell surface death receptor
    Orthology source: HomoloGene
  • Synonyms
    ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
  • Links
    NCBI Gene ID: 355
    neXtProt AC: NX_P25445

  • Chr Location
    10q24.1; chr10:88969801-89017059 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    4 with Fas mouse models; 1 with human FAS associations

Human Disease Mouse Models
       Autoimmune Lymphoproliferative Syndrome; ALPS   OMIM: 601859 View 3 models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100
Sjogren Syndrome   OMIM: 270150 View 4 models
Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    25 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    183 phenotypes from 10 alleles in 39 genetic backgrounds
    217 phenotypes from multigenic genotypes
    2 images
    857 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    2
  • Spontaneous
    2
  • Targeted
    9
  • Transgenic
    2
  • Incidental Mutations
Mutations in this locus affect immune function and homozygotes show varying severity of lymphadenopathy, splenomegaly, lymphocytic infiltrations, elevated immunoglobulin levels, autoantibodies, impaired clonal deletion of T cells, and lupus-like disease.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024778 Ensembl Gene Model | MGI Sequence Detail 37112 C57BL/6J ±  kb
transcript ENSMUST00000025691 Ensembl | MGI Sequence Detail 1486 Not Applicable  
polypeptide ENSMUSP00000025691 Ensembl | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    352 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 34
    Genomic 2
    cDNA 27
    Primer pair 2
    Other 3

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-11878, MGD-MRK-9711, MGI:2147489
References
more
  • Summaries
    All 1157
    Developmental Gene Expression 25
    Diseases 25
    Gene Ontology 46
    Phenotypes 857
  • Earliest
    J:13747 Murphy ED, et al., Lymphoproliferation (lpr). Mouse News Lett. 1978;58:47
  • Latest
    J:226196 Shi L, et al., CD47 deficiency ameliorates autoimmune nephritis in Fas(lpr) mice by suppressing IgG autoantibody production. J Pathol. 2015 Nov;237(3):285-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory