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Fas Gene Detail
Summary
  • Symbol
    Fas
  • Name
    Fas (TNF receptor superfamily member 6)
  • Synonyms
    APO-1, CD95, TNFR6, Tnfrsf6
  • Feature Type
    protein coding gene
  • IDs
    MGI:95484
    NCBI Gene: 14102
  • Gene Overview
    MyGene.info: FAS
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:34290659-34327770 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 29.48 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    351 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95484
protein coding gene Chr19:34290659-34327775 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025056
protein coding gene Chr19:33031602-33070458 (+)
A/J MGP_AJ_G0025034
protein coding gene Chr19:31421340-31459421 (+)
AKR/J MGP_AKRJ_G0025000
protein coding gene Chr19:32486067-32523040 (+)
BALB/cJ MGP_BALBcJ_G0025030
protein coding gene Chr19:31536947-31573182 (+)
C3H/HeJ MGP_C3HHeJ_G0024789
protein coding gene Chr19:32582692-32625318 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025471
protein coding gene Chr19:33974321-34011963 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022889
protein coding gene Chr19:30866241-30901335 (+)
CAST/EiJ MGP_CASTEiJ_G0024259
protein coding gene Chr19:32323626-32364667 (+)
CBA/J MGP_CBAJ_G0024766
protein coding gene Chr19:35563738-35599060 (+)
DBA/2J MGP_DBA2J_G0024898
protein coding gene Chr19:31324524-31360750 (+)
FVB/NJ MGP_FVBNJ_G0024859
protein coding gene Chr19:31166699-31203368 (+)
LP/J MGP_LPJ_G0024984
protein coding gene Chr19:33114032-33151209 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024890
protein coding gene Chr19:35364951-35401896 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025529
protein coding gene Chr19:32584637-32625217 (+)
PWK/PhJ MGP_PWKPhJ_G0024008
protein coding gene Chr19:31130249-31167948 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023809
protein coding gene Chr19:31432436-31473844 (+)
WSB/EiJ MGP_WSBEiJ_G0024323
protein coding gene Chr19:32656602-32693398 (+)



Homology
more
  • Human Ortholog
    FAS, Fas cell surface death receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FAS, Fas cell surface death receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
  • Links
    NCBI Gene ID: 355
    neXtProt AC: NX_P25445
    UniProt: P25445

  • Chr Location
    10q23.31; chr10:88968429-89017061 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Fas mouse models; 1 with human FAS associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
View 4 models
IDs
View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    19 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    186 phenotypes from 10 alleles in 39 genetic backgrounds
    219 phenotypes from multigenic genotypes
    2 images
    933 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this locus affect immune function and homozygotes show varying severity of lymphadenopathy, splenomegaly, lymphocytic infiltrations, elevated immunoglobulin levels, autoantibodies, impaired clonal deletion of T cells, and lupus-like disease.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024778 Ensembl Gene Model | MGI Sequence Detail 37112 C57BL/6J ±  kb
    transcript ENSMUST00000025691 Ensembl | MGI Sequence Detail 1486 Not Applicable  
    polypeptide ENSMUSP00000025691 Ensembl | MGI Sequence Detail 327 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 2
      cDNA 28
      Primer pair 2
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11878, MGD-MRK-9711, MGI:2147489
    References
    more
    • Summaries
      All 1327
      Developmental Gene Expression 29
      Diseases 19
      Gene Ontology 45
      Phenotypes 933
    • Earliest
      J:27634 Andrews BS, et al., Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med. 1978 Nov 1;148(5):1198-215
    • Latest
      J:266578 Plein A, et al., Erythro-myeloid progenitors contribute endothelial cells to blood vessels. Nature. 2018 Oct;562(7726):223-228

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory