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Fas
Gene Detail
Symbol

Name
ID
Fas
Fas (TNF receptor superfamily member 6)
MGI:95484
Synonyms
APO-1, CD95, TNFR6, Tnfrsf6
Feature Type
protein coding gene
Genetic Map
Chromosome 19
29.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr19:34290659-34327770 bp, + strand
From NCBI annotation of GRCm38

  37112 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tumor necrosis factor receptor superfamily member 6
Gene Tree: Fas

Human
homologs
Human Homolog FAS, Fas cell surface death receptor
NCBI Gene ID 355
neXtProt AC  NX_P25445
Human Synonyms  ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Human Chr (Location)  10q24.1; chr10:88969796-89017059 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FAS
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Spontaneous(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this locus affect immune function and homozygotes show varying severity of lymphadenopathy, splenomegaly, lymphocytic infiltrations, elevated immunoglobulin levels, autoantibodies, impaired clonal deletion of T cells, and lupus-like disease.
 
Human Diseases Modeled Using Mouse Fas (4)    Alleles Annotated to Human Diseases(4)    Phenotype Images(2)
Interactions
Fas interacts with 92 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (96 annotations)
Process activation-induced cell death of T cells, apoptotic process, ...
Component apical dendrite, apical plasma membrane, ...
Function identical protein binding, kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (76)    Tissues (62)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Western blot 6
RT-PCR 46
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(2) cDNA(27) Primer pair(2) Other(3)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000024778 (Evidence)
Entrez Gene14102 (Evidence)
UniGene1626
DoTSDT.485725, DT.91304076
PDB3OQ9
Consensus CDS ProjectCCDS29758.1, CCDS50420.1
International Mouse Knockout Project StatusFas
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14102 NCBI Gene Model | MGI Sequence Detail 37112 C57BL/6J ±  kb
transcript NM_007987 RefSeq | MGI Sequence Detail 1486 Not Specified 
polypeptide P25446 UniProt | EBI | MGI Sequence Detail 327 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(5)
Polymorphisms
All PCR and RFLP(5) : PCR(1) RFLP(4) SNPs within 2kb(352 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR008063 Fas receptor
InterPro IPR001368 TNFR/NGFR cysteine-rich region
Protein Ontology PR:000001962 tumor necrosis factor receptor superfamily member 6
Graphical View of Protein Domain Structure
References
(Earliest) J:13747 Murphy ED, et al., Lymphoproliferation (lpr). Mouse News Lett. 1978;58:47
(Latest) J:212771 Koga T, et al., CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance. J Clin Invest. 2014 May 1;124(5):2234-45
All references(1136)
Disease annotation references (17)
Other
accession IDs
MGD-MRK-11878, MGD-MRK-9711, MGI:2147489

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory