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Fas Gene Detail
Summary
  • Symbol
    Fas
  • Name
    Fas (TNF receptor superfamily member 6)
  • Synonyms
    APO-1, CD95, TNFR6, Tnfrsf6
  • Feature Type
    protein coding gene
  • IDs
    MGI:95484
    NCBI Gene: 14102
  • Gene Overview
    MyGene.info: FAS
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:34290659-34327770 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37112 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 29.48 cM
  • Mapping Data
    21 experiments
Homology
more
  • Human Ortholog
    FAS, Fas cell surface death receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FAS, Fas cell surface death receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
  • Links
    NCBI Gene ID: 355
    neXtProt AC: NX_P25445
    UniProt: P25445

  • Chr Location
    10q23.31; chr10:88968429-89017061 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Fas mouse models; 1 with human FAS associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
View 4 models
IDs
View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    19 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    186 phenotypes from 10 alleles in 39 genetic backgrounds
    219 phenotypes from multigenic genotypes
    2 images
    907 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this locus affect immune function and homozygotes show varying severity of lymphadenopathy, splenomegaly, lymphocytic infiltrations, elevated immunoglobulin levels, autoantibodies, impaired clonal deletion of T cells, and lupus-like disease.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024778 Ensembl Gene Model | MGI Sequence Detail 37112 C57BL/6J ±  kb
    transcript ENSMUST00000025691 Ensembl | MGI Sequence Detail 1486 Not Applicable  
    polypeptide ENSMUSP00000025691 Ensembl | MGI Sequence Detail 327 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      351 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 2
      cDNA 27
      Primer pair 2
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11878, MGD-MRK-9711, MGI:2147489
    References
    more
    • Summaries
      All 1301
      Developmental Gene Expression 27
      Diseases 19
      Gene Ontology 46
      Phenotypes 907
    • Earliest
      J:27634 Andrews BS, et al., Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med. 1978 Nov 1;148(5):1198-215
    • Latest
      J:258813 Kou X, et al., The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing. Sci Transl Med. 2018 Mar 14;10(432)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory