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Fas
Gene Detail
Symbol

Name
ID
Fas
Fas (TNF receptor superfamily member 6)
MGI:95484
Synonyms
APO-1, CD95, TNFR6, Tnfrsf6
Feature Type
protein coding gene
Genetic Map
Chromosome 19
29.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr19:34290659-34327770 bp, + strand
From Ensembl annotation of GRCm38

  37112 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FAS
Protein SuperFamily: tumor necrosis factor receptor superfamily member 6
Gene Tree: Fas

Human
homologs
FAS, Fas cell surface death receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 355
neXtProt AC: NX_P25445

Human Synonyms: ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6

Human Chr (Location): 10q24.1; chr10:88969801-89017059 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FAS

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Chemically induced (ENU)(2) Spontaneous(2) Targeted(9) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this locus affect immune function and homozygotes show varying severity of lymphadenopathy, splenomegaly, lymphocytic infiltrations, elevated immunoglobulin levels, autoantibodies, impaired clonal deletion of T cells, and lupus-like disease.
 
Human Diseases Modeled in Mice Using Fas (3)    Mutations Annotated to Human Diseases (5)    Phenotype Images(2)
Interactions
Fas interacts with 92 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (97 annotations)
Process activation-induced cell death of T cells, apoptotic process, ...
Component apical dendrite, apical plasma membrane, ...
Function identical protein binding, kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (76)    Tissues (62)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Western blot 6
RT-PCR 46
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FAS ; Xenbase fas    NEW 
Molecular
reagents
All nucleic(34) Genomic(2) cDNA(27) Primer pair(2) Other(3)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000024778 (Evidence)
Entrez Gene 14102 (Evidence)
UniGene 1626
DoTS DT.485725, DT.91304076
PDB 3OQ9
Consensus CDS Project CCDS29758.1, CCDS50420.1
International Mouse Phenotyping Consortium Status Fas
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024778 Ensembl Gene Model | MGI Sequence Detail 37112 C57BL/6J ±  kb
transcript ENSMUST00000025691 Ensembl | MGI Sequence Detail 1486 Not Applicable 
polypeptide ENSMUSP00000025691 Ensembl | MGI Sequence Detail 327 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(6) UniProt(3)
Polymorphisms
All PCR and RFLP(5) : PCR(1) RFLP(4) SNPs within 2kb(352 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR008063 Fas receptor
InterPro IPR001368 TNFR/NGFR cysteine-rich region
Protein Ontology PR:000001962 tumor necrosis factor receptor superfamily member 6
References
(Earliest) J:13747 Murphy ED, et al., Lymphoproliferation (lpr). Mouse News Lett. 1978;58:47
(Latest) J:221793 Okamura T, et al., TGF-beta3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses. Nat Commun. 2015;6:6329
All references(1149)
Disease annotation references (18)
Other
accession IDs
MGD-MRK-11878, MGD-MRK-9711, MGI:2147489

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory