Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables identical protein binding activity. Involved in circadian rhythm; extrinsic apoptotic signaling pathway via death domain receptors; and positive regulation of protein-containing complex assembly. Acts upstream of or within several processes, including activation-induced cell death of T cells; cellular response to lithium ion; and regulation of hemopoiesis. Located in external side of plasma membrane and extracellular region. Part of CD95 death-inducing signaling complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb segment. Used to study Sjogren's syndrome; autoimmune lymphoproliferative syndrome; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor).
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