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Dlx4 Gene Detail
Summary
  • Symbol
    Dlx4
  • Name
    distal-less homeobox 4
  • Synonyms
    DII D, Dlx-4, Dlx7
  • Feature Type
    protein coding gene
  • IDs
    MGI:94904
    NCBI Gene: 13394
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr11:95031273-95037089 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.01 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94904
 protein coding gene Chr11:95031273-95037116 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018978
 protein coding gene Chr11:97330264-97336080 (-)
A/J MGP_AJ_G0018946
 protein coding gene Chr11:93400518-93406329 (-)
AKR/J MGP_AKRJ_G0018916
 protein coding gene Chr11:96289319-96295130 (-)
BALB/cJ MGP_BALBcJ_G0018919
 protein coding gene Chr11:93872124-93877938 (-)
C3H/HeJ MGP_C3HHeJ_G0018733
 protein coding gene Chr11:96413972-96419783 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019371
 protein coding gene Chr11:100392319-100398135 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017002
 protein coding gene Chr11:90886055-90892095 (-)
CAST/EiJ MGP_CASTEiJ_G0018287
 protein coding gene Chr11:97212949-97218769 (-)
CBA/J MGP_CBAJ_G0018704
 protein coding gene Chr11:104493003-104498814 (-)
DBA/2J MGP_DBA2J_G0018812
 protein coding gene Chr11:92974656-92980472 (-)
FVB/NJ MGP_FVBNJ_G0018801
 protein coding gene Chr11:92438113-92443929 (-)
LP/J MGP_LPJ_G0018882
 protein coding gene Chr11:97898751-97904567 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018828
 protein coding gene Chr11:104542061-104547875 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019411
 protein coding gene Chr11:96553634-96559448 (-)
PWK/PhJ MGP_PWKPhJ_G0018058
 protein coding gene Chr11:93892069-93897877 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017847
 protein coding gene Chr11:96237654-96243449 (-)
WSB/EiJ MGP_WSBEiJ_G0018336
 protein coding gene Chr11:96472607-96478421 (-)



Homology
more
  • Human Ortholog
    DLX4, distal-less homeobox 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLX4, distal-less homeobox 4
  • Synonyms
    BP1, DLX7, DLX8, DLX9, OFC15
  • Links
    NCBI Gene ID: 1748
    neXtProt AC: NX_Q92988
    UniProt: Q92988

  • Chr Location
    17q21.33; chr17:49968572-49974959 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DLX4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    981
  • Tissues
    166
  • cDNA Data
    16
  • Literature Summary
    27
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020871 Ensembl Gene Model | MGI Sequence Detail 5817 C57BL/6J ±  kb
transcript ENSMUST00000021241 Ensembl | MGI Sequence Detail 2282 Not Applicable  
polypeptide ENSMUSP00000021241 Ensembl | MGI Sequence Detail 240 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    Genomic 2
    cDNA 16
    Primer pair 2
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38218, MGD-MRK-8860, MGD-MRK-8864, MGI:109174
References
more
  • Summaries
    All 67
    Developmental Gene Expression 27
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:639 Robinson GW, et al., Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain. New Biol. 1991 Dec;3(12):1183-94
  • Latest
    J:345597 Quilez S, et al., Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects. Front Cell Dev Biol. 2024;12:1256465
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory