Dlx4 MGI Mouse Gene Detail - MGI:94904

Symbol

Dlx4
Name

distal-less homeobox 4
Synonyms

DII D, Dlx-4, Dlx7

Feature Type

protein coding gene
IDs

MGI:94904
NCBI Gene: 13394
Alliance

genome feature page

Sequence Map

Chr11:95031273-95037089 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.01 cM
Mapping Data

3 experiments

SNPs within 2kb

208 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_94904	protein coding gene	Chr11:95031273-95037116 (-)
129S1/SvImJ	ENSMUSG00200049107	protein coding gene	Chr11:92274574-92280390 (-)
A/J	ENSMUSG00195048610	protein coding gene	Chr11:91996018-92001829 (-)
AKR/J	ENSMUSG00220045264	protein coding gene	Chr11:92254949-92260760 (-)
BALB/cJ	ENSMUSG00180042887	protein coding gene	Chr11:92243062-92248876 (-)
C3H/HeJ	ENSMUSG00175046049	protein coding gene	Chr11:92255464-92261275 (-)
C57BL/6NJ	ENSMUSG00215053814	protein coding gene	Chr11:91847628-91853444 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017002	protein coding gene	Chr11:90886055-90892095 (-)
CAST/EiJ	ENSTCUG00005015417	protein coding gene	Chr11:91705038-91710858 (-)
CBA/J	ENSMUSG00210052774	protein coding gene	Chr11:91958862-91964673 (-)
DBA/2J	ENSMUSG00185040676	protein coding gene	Chr11:92296328-92302144 (-)
FVB/NJ	ENSMUSG00205033673	protein coding gene	Chr11:92161590-92167406 (-)
JF1/MsJ	ENSUMUG00000027791	protein coding gene	Chr11:92610988-92616799 (-)
LP/J	ENSMUSG00230044313	protein coding gene	Chr11:93357797-93363613 (-)
NOD/ShiLtJ	ENSMUSG00190048506	protein coding gene	Chr11:92336840-92342654 (-)
NZO/HlLtJ	ENSMUSG00225049093	protein coding gene	Chr11:95404520-95410334 (-)
PWK/PhJ	ENSLUMG00010028413	protein coding gene	Chr11:92159253-92165061 (-)
SPRET/EiJ	ENSMSPG00010044126	protein coding gene	Chr11:92640221-92646012 (-)
WSB/EiJ	ENSIUOG00005043795	protein coding gene	Chr11:92106772-92112586 (-)

Human Ortholog

DLX4, distal-less homeobox 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DLX4, distal-less homeobox 4
Synonyms

BP1, DLX7, DLX8, DLX9, OFC15
Links

HGNC:2917

NCBI Gene ID: 1748

UniProt: Q92988
Chr Location

17q21.33; chr17:49968572-49974959 (+) GRCh38

MGI Vertebrate Homology

Dlx4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DLX4
Gene Tree

Dlx4

Diseases

1 with human DLX4 associations

				Human Disease	Mouse Models
				orofacial cleft 15 IDs orofacial cleft 15 DOID:0080408 OMIM:616788

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Targeted

6
Genomic Mutations

2 involving Dlx4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are healthy and do not exhibit any overt altered phenotype, particularly no skin defects.

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All GO Annotations

24
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

875
Tissues

169
cDNA Data

17
Literature Summary

27

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN dlx4a, dlx4b

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All Sequences

34
RefSeq

4
UniProt

1
CCDS

CCDS25273.1

Ensembl

ENSMUSG00000020871 (Evidence)
NCBI Gene

13394

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020871	Ensembl Gene Model \| MGI Sequence Detail	5817	C57BL/6J	± kb
transcript	ENSMUST00000021241	Ensembl \| MGI Sequence Detail	2282	Not Applicable
polypeptide	ENSMUSP00000021241	Ensembl \| MGI Sequence Detail	240	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006530 homeobox protein DLX-4

(term hierarchy)
InterPro Domains

IPR050460 Distal-less homeobox transcription factors

IPR000047 Helix-turn-helix motif

IPR017970 Homeobox, conserved site

IPR001356 Homeodomain

IPR009057 Homeodomain-like superfamily

IPR020479 Homeodomain, metazoa
GlyGen

P70436 1 site

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All nucleic 25

Genomic 2

cDNA 17

Primer pair 3

Other 3

Antibodies 1

Microarray probesets 3

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MGD-MRK-38218, MGD-MRK-8860, MGD-MRK-8864, MGI:109174

Summaries

All 77

Developmental Gene Expression 27

Gene Ontology 7

Phenotypes 13
Earliest

J:639 Robinson GW, et al., Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain. New Biol. 1991 Dec;3(12):1183-94
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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