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Dlx4 Gene Detail
Summary
  • Symbol
    Dlx4
  • Name
    distal-less homeobox 4
  • Synonyms
    DII D, Dlx-4, Dlx7
  • Feature Type
    protein coding gene
  • IDs
    MGI:94904
    NCBI Gene: 13394
  • Gene Overview
    MyGene.info: DLX4
Location & Maps
more
  • Sequence Map
    Chr11:95140447-95146263 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5817 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 59.01 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DLX4, distal-less homeobox 4
  • Vertebrate Orthologs
    6
  • Human Ortholog
    DLX4, distal-less homeobox 4
    Orthology source: HomoloGene
  • Synonyms
    BP1, DLX7, DLX8, DLX9, OFC15
  • Links
    NCBI Gene ID: 1748
    neXtProt AC: NX_Q92988

  • Chr Location
    17q21.33; chr17:49969198-49974959 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DLX4 associations

Human Disease Mouse Models
       Orofacial Cleft 15; OFC15   OMIM: 616788
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    4
  • Targeted
    4
  • Genomic Mutations
    2 involving Dlx4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001615 VEGA Gene Model | MGI Sequence Detail 5817 C57BL/6J ±  kb
transcript OTTMUST00000003156 VEGA | MGI Sequence Detail 2282 Not Applicable  
polypeptide OTTMUSP00000001528 VEGA | MGI Sequence Detail 240 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    81 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 2
    cDNA 13
    Primer pair 1
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38218, MGD-MRK-8860, MGD-MRK-8864, MGI:109174
References
more
  • Summaries
    All 49
    Developmental Gene Expression 18
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:639 Robinson GW, et al., Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain. New Biol. 1991 Dec;3(12):1183-94
  • Latest
    J:224001 Wu D, et al., DLX4 is associated with orofacial clefting and abnormal jaw development. Hum Mol Genet. 2015 Aug 1;24(15):4340-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory