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Sh2b3
Gene Detail
 Symbol
Name
ID
Sh2b3
SH2B adaptor protein 3
MGI:893598
Synonyms Lnk
Feature Type protein coding gene
Genetic Map
Chromosome 5
61.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:121815488-121836859 bp, - strand
From VEGA annotation of GRCm38

  21372 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36179  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sh2b3

Human
homologs
Human Homolog SH2B3, SH2B adaptor protein 3
NCBI Gene ID 10019
neXtProt AC  NX_Q9UQQ2
Human Synonyms  IDDM20, LNK
Human Chr (Location)  12q24; chr12:111405917-111451623 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human SH2B3
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Mice homozygous for a knock-out allele exhibit severe perturbations in hematopoiesis, splenomegaly, and abnormal lymphoid and myeloid homeostasis. Mice homozygous for a different knock-out allele display altered mobility of hematopoietic stem/progenitor cells.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell differentiation, embryonic hemopoiesis, ...
Component intracellular
Function protein binding, signal transducer activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (13)    Tissues (7)    Images (3)
Theiler Stages: 15, 19, 22, 23, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 6
RT-PCR 6
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) Genomic(6) cDNA(14) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000029807 (Evidence)
Ensembl Gene ModelENSMUSG00000042594 (Evidence)
Entrez Gene16923 (Evidence)
Consensus CDS ProjectCCDS19641.1
International Mouse Knockout Project StatusSh2b3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029807 VEGA Gene Model | MGI Sequence Detail 21372 C57BL/6J ±  kb
transcript OTTMUST00000073987 VEGA | MGI Sequence Detail 4195 Not Applicable 
polypeptide OTTMUSP00000038367 VEGA | MGI Sequence Detail 548 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(12) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015012 Phenylalanine zipper
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000980 SH2 domain
Protein Ontology PR:000014811 SH2B adapter protein 3
References (Earliest) J:40949 Takaki S, et al., Characterization of Lnk. An adaptor protein expressed in lymphocytes. J Biol Chem. 1997 Jun 6;272(23):14562-70
(Latest) J:205505 Louria-Hayon I, et al., Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20599-604
All references(52)
Other
accession IDs
MGI:2140878

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory