Sh2b3
Gene Detail

Symbol Name ID

Sh2b3 SH2B adaptor protein 3 MGI:893598

Synonyms

Lnk

Feature Type

protein coding gene

Genetic Map

Chromosome 5

61.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:121815488-121836859 bp, - strand From VEGA annotation of GRCm38   21372 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36179  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sh2b3

Human homologs

Human Homolog		SH2B3, SH2B adaptor protein 3
NCBI Gene ID		10019
neXtProt AC		NX_Q9UQQ2
Human Synonyms		IDDM20, LNK
Human Chr (Location)		12q24; chr12:111843752-111889427 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human SH2B3

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit severe perturbations in hematopoiesis, splenomegaly, and abnormal lymphoid and myeloid homeostasis. Mice homozygous for a different knock-out allele display altered mobility of hematopoietic stem/progenitor cells.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	cell differentiation, embryonic hemopoiesis, ...
Function	phospholipid binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (13)    Tissues (7)    Images (3)
Theiler Stages: 15, 19, 22, 23, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	6
RT-PCR	6

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(6) cDNA(14) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000029807 (Evidence)
Ensembl Gene Model	ENSMUSG00000042594 (Evidence)
Entrez Gene	16923 (Evidence)
Consensus CDS Project	CCDS19641.1
International Mouse Knockout Project Status	Sh2b3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029807	VEGA Gene Model | MGI Sequence Detail	21372	C57BL/6J
transcript	OTTMUST00000073987	VEGA | MGI Sequence Detail	4195	Not Applicable
polypeptide	OTTMUSP00000038367	VEGA | MGI Sequence Detail	548	Not Applicable

All sequences(57) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(5 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015012	Phenylalanine zipper
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR000980	SH2 domain
Protein Ontology	PR:000014811	SH2B adapter protein 3

References

(Earliest) J:40949 Takaki S, et al., Characterization of Lnk. An adaptor protein expressed in lymphocytes. J Biol Chem. 1997 Jun 6;272(23):14562-70
(Latest) J:192918 Lin DC, et al., Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3. Blood. 2012 Oct 18;120(16):3310-7
All references(50)

Other accession IDs

MGI:2140878