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Sh2b3
Gene Detail
Symbol

Name
ID
Sh2b3
SH2B adaptor protein 3
MGI:893598
Synonyms
Lnk
Feature Type
protein coding gene
Genetic Map
Chromosome 5
61.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:121815488-121836859 bp, - strand
From VEGA annotation of GRCm38

  21372 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36179  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SH2B3
Gene Tree: Sh2b3

Human
homologs
SH2B3, SH2B adaptor protein 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10019
neXtProt AC: NX_Q9UQQ2

Human Synonyms: IDDM20, LNK

Human Chr (Location): 12q24; chr12:111405108-111451624 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human SH2B3

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit severe perturbations in hematopoiesis, splenomegaly, and abnormal lymphoid and myeloid homeostasis. Mice homozygous for a different knock-out allele display altered mobility of hematopoietic stem/progenitor cells.
 
Phenotype Images(1)
Interactions
Sh2b3 interacts with 331 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell differentiation, embryonic hemopoiesis, ...
Component intracellular
Function protein binding, signaling adaptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (13)    Tissues (7)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 6
RT-PCR 6
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sh2b3    NEW 
Molecular
reagents
All nucleic(21) Genomic(6) cDNA(14) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000029807 (Evidence)
Ensembl Gene Model ENSMUSG00000042594 (Evidence)
Entrez Gene 16923 (Evidence)
Consensus CDS Project CCDS19641.1
International Mouse Phenotyping Consortium Status Sh2b3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029807 VEGA Gene Model | MGI Sequence Detail 21372 C57BL/6J ±  kb
transcript OTTMUST00000073987 VEGA | MGI Sequence Detail 4195 Not Applicable 
polypeptide OTTMUSP00000038367 VEGA | MGI Sequence Detail 548 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(20) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015012 Phenylalanine zipper
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000980 SH2 domain
Protein Ontology PR:000014811 SH2B adapter protein 3
References
(Earliest) J:40949 Takaki S, et al., Characterization of Lnk. An adaptor protein expressed in lymphocytes. J Biol Chem. 1997 Jun 6;272(23):14562-70
(Latest) J:220548 Saleh MA, et al., Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation. J Clin Invest. 2015 Mar 2;125(3):1189-202
All references(52)
Other
accession IDs
MGI:2140878

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory