Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables protein tyrosine kinase binding activity; signaling receptor complex adaptor activity; and stem cell factor receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; megakaryocyte development; and negative regulation of signal transduction. Acts upstream of or within with a negative effect on cellular response to chemokine. Acts upstream of or within embryonic hemopoiesis; hematopoietic stem cell differentiation; and intracellular signal transduction. Predicted to be active in plasma membrane. Is expressed in aorta-gonad-mesonephros; dorsal aorta; liver; lower jaw molar; and upper jaw molar. Used to study chronic myeloid leukemia. Human ortholog(s) of this gene implicated in colorectal cancer; essential thrombocythemia; familial erythrocytosis 1; myelofibrosis; and type 1 diabetes mellitus. Orthologous to human SH2B3 (SH2B adaptor protein 3).