Sh2b3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sh2b3
SH2B adaptor protein 3
MGI:893598

38 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sh2b3^em1Cgv/Sh2b3⁺ C57BL/6NCrl-Sh2b3^em1Cgv	abnormal B cell activation	J:358257
	abnormal spleen marginal zone morphology	J:358257
	abnormal T cell differentiation	J:358257
	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:358257
	increased double-negative T cell number	J:358257
	increased effector memory CD4-positive, alpha-beta T cell number	J:358257
	increased effector memory CD8-positive, alpha-beta T cell number	J:358257
Sh2b3^em1Cgv/Sh2b3^em1Cgv C57BL/6NCrl-Sh2b3^em1Cgv	abnormal B cell activation	J:358257
	abnormal B cell number	J:358257
	abnormal spleen marginal zone morphology	J:358257
	abnormal T cell differentiation	J:358257
	decreased mature B cell number	J:358257
	enlarged spleen	J:358257
	increased activated T cell number	J:358257
	increased B cell number	J:358257
	increased double-negative T cell number	J:358257
	increased effector memory CD8-positive, alpha-beta T cell number	J:358257
	increased leukocyte cell number	J:358257
	increased lymphocyte cell number	J:358257
	increased pre-B cell number	J:358257
	increased susceptibility to autoimmune disorder	J:358257
	increased T cell number	J:358257
	increased transitional stage B cell number	J:358257
	spleen hyperplasia	J:358257
Sh2b3^em2Cgv/Sh2b3⁺ C57BL/6NCrl-Sh2b3^em2Cgv	abnormal spleen marginal zone morphology	J:358257
Sh2b3^em2Cgv/Sh2b3^em2Cgv C57BL/6NCrl-Sh2b3^em2Cgv	abnormal spleen marginal zone morphology	J:358257
	abnormal T cell differentiation	J:358257
	decreased mature B cell number	J:358257
	enlarged spleen	J:358257
	increased activated T cell number	J:358257
	increased B cell number	J:358257
	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:358257
	increased effector memory CD4-positive, alpha-beta T cell number	J:358257
	increased effector memory CD8-positive, alpha-beta T cell number	J:358257
	increased leukocyte cell number	J:358257
	increased lymphocyte cell number	J:358257
	increased T cell number	J:358257
	increased transitional stage B cell number	J:358257
	spleen hyperplasia	J:358257
Sh2b3^em3Cgv/Sh2b3⁺ C57BL/6NCrl-Sh2b3^em3Cgv	increased transitional stage B cell number	J:358257
Sh2b3^em3Cgv/Sh2b3^em3Cgv C57BL/6NCrl-Sh2b3^em3Cgv	abnormal spleen marginal zone morphology	J:358257
	enlarged spleen	J:358257
	increased B cell number	J:358257
	increased leukocyte cell number	J:358257
	increased lymphocyte cell number	J:358257
	increased T cell number	J:358257
	increased transitional stage B cell number	J:358257
	spleen hyperplasia	J:358257
Sh2b3^tm1Paw/Sh2b3^tm1Paw B6.129-Sh2b3^tm1Paw	anemia	J:107464
	increased bone marrow cell number	J:107464
	increased erythroid progenitor cell number	J:107464
	spleen hyperplasia	J:107464
Sh2b3^tm1Paw/Sh2b3^tm1Paw either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal granulocyte differentiation	J:77248
	abnormal leukocyte cell number	J:77248
	abnormal megakaryocyte morphology	J:77248
	abnormal monocyte differentiation	J:77248
	enlarged lymph nodes	J:77248
	enlarged spleen	J:77248
	extramedullary hematopoiesis	J:77248
	increased B cell number	J:77248
	increased cell proliferation	J:77248
	increased megakaryocyte cell number	J:77248
	spleen fibrosis	J:77248
	thrombocytosis	J:77248
Sh2b3^tm1Paw/Sh2b3^tm1Paw involves: 129S1/Sv * 129X1/SvJ	decreased B cell number	J:161643
	enlarged spleen	J:161643
	extramedullary hematopoiesis	J:161643
	increased granulocyte number	J:161643
	increased leukocyte cell number	J:161643
	increased lymphocyte cell number	J:161643
	increased monocyte cell number	J:161643
	increased neutrophil cell number	J:161643
	myeloid hyperplasia	J:161643
	thrombocytosis	J:161643
Sh2b3^tm1Rmp/Sh2b3^tm1Rmp involves: 129S4/SvJae	abnormal hematopoietic stem cell morphology	J:131265

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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