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Ager
Gene Detail
Symbol

Name
ID
Ager
advanced glycosylation end product-specific receptor
MGI:893592
Synonyms
RAGE
Feature Type
protein coding gene
Genetic Map
Chromosome 17
18.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:34597862-34600936 bp, + strand
From VEGA annotation of GRCm38

  3075 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:883  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: AGER
Protein SuperFamily: advanced glycosylation end products receptor
Gene Tree: Ager

Human
homologs
AGER, advanced glycosylation end product-specific receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 177
neXtProt AC: NX_Q15109

Human Synonyms: RAGE

Human Chr (Location): 6p21.3; chr6:32180968-32184322 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(5) Transgenic(1)
Incidental mutations (data from APF , CvDC )
 
Homozygotes for a null allele show increased bone mass and strength, reduced osteoclast number, abnormal blood vessel healing, and altered development of nephropathy and pain perception in induced diabetes. Homozygotes for another null allele show restored diabetes-induced angiogenic responses.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Ager interacts with 203 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (81)    Tissues (49)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 35
RT-PCR 46
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(23) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037074 (Evidence)
Ensembl Gene Model ENSMUSG00000015452 (Evidence)
Entrez Gene 11596 (Evidence)
UniGene 3383
DFCI TC1585993, TC1684508
NIA Mouse Gene Index U017860
PDB 4IM8
Consensus CDS Project CCDS28649.1, CCDS70795.1, CCDS70796.1
International Mouse Phenotyping Consortium Status Ager
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037074 VEGA Gene Model | MGI Sequence Detail 3075 C57BL/6J ±  kb
transcript OTTMUST00000095384 VEGA | MGI Sequence Detail 1370 Not Applicable 
polypeptide OTTMUSP00000053230 VEGA | MGI Sequence Detail 402 Not Applicable 

For the selected sequences
All sequences(123) RefSeq(19) UniProt(21)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000003828 advanced glycosylation end product-specific receptor
References
(Earliest) J:55874 Hofmann MA, et al., RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999 Jun 25;97(7):889-901
(Latest) J:218090 Chen X, et al., RAGE expression in tumor-associated macrophages promotes angiogenesis in glioma. Cancer Res. 2014 Dec 15;74(24):7285-97
All references(173)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory