Ager
Gene Detail

Symbol Name ID

Ager advanced glycosylation end product-specific receptor MGI:893592

Synonyms

RAGE

Feature Type

protein coding gene

Genetic Map

Chromosome 17

18.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:34597862-34600934 bp, + strand From VEGA annotation of GRCm38   3073 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:883  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: advanced glycosylation end products receptor
Gene Tree: Ager

Human homologs

Human Homolog		AGER, advanced glycosylation end product-specific receptor
NCBI Gene ID		177
neXtProt AC		NX_Q15109
Human Synonyms		RAGE
Human Chr (Location)		6p21.3; chr6:32148745-32152099 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygotes for a null allele show increased bone mass and strength, reduced osteoclast number, abnormal blood vessel healing, and altered development of nephropathy and pain perception in induced diabetes. Homozygotes for another null allele show restored diabetes-induced angiogenic responses.

 
Human Diseases Modeled Using Mouse Ager (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	calcium ion homeostasis, induction of positive chemotaxis, ...
Component	axon, basal plasma membrane, ...
Function	advanced glycation end-product receptor activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (81)    Tissues (49)    Images (23)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	35
RT-PCR	46

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(1) cDNA(23) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037074 (Evidence)
Ensembl Gene Model	ENSMUSG00000015452 (Evidence)
Entrez Gene	11596 (Evidence)
UniGene	3383
DFCI	TC1585993, TC1684508
NIA Mouse Gene Index	U017860
Consensus CDS Project	CCDS28649.1
International Mouse Knockout Project Status	Ager

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037074	VEGA Gene Model | MGI Sequence Detail	3073	C57BL/6J
transcript	OTTMUST00000095384	VEGA | MGI Sequence Detail	1370	Not Applicable
polypeptide	OTTMUSP00000053230	VEGA | MGI Sequence Detail	402	Not Applicable

All sequences(112) RefSeq(11) UniProt(20)

Polymorphisms

SNPs(12 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013162	CD80-like, immunoglobulin C2-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
Protein Ontology	PR:000003828	advanced glycosylation end product-specific receptor

References

(Earliest) J:55874 Hofmann MA, et al., RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999 Jun 25;97(7):889-901
(Latest) J:192593 Vernon PJ, et al., The receptor for advanced glycation end products promotes pancreatic carcinogenesis and accumulation of myeloid-derived suppressor cells. J Immunol. 2013 Feb 1;190(3):1372-9
All references(137)