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Ager
Gene Detail
Symbol

Name
ID
Ager
advanced glycosylation end product-specific receptor
MGI:893592
Synonyms
RAGE
Feature Type
protein coding gene
Genetic Map
Chromosome 17
18.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:34597862-34600936 bp, + strand
From VEGA annotation of GRCm38

  3075 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:883  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: advanced glycosylation end products receptor
Gene Tree: Ager

Human
homologs
Human Homolog AGER, advanced glycosylation end product-specific receptor
NCBI Gene ID 177
neXtProt AC  NX_Q15109
Human Synonyms  RAGE
Human Chr (Location)  6p21.3; chr6:32180968-32184322 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Homozygotes for a null allele show increased bone mass and strength, reduced osteoclast number, abnormal blood vessel healing, and altered development of nephropathy and pain perception in induced diabetes. Homozygotes for another null allele show restored diabetes-induced angiogenic responses.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Ager interacts with 203 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (81)    Tissues (49)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 35
RT-PCR 46
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(23) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037074 (Evidence)
Ensembl Gene ModelENSMUSG00000015452 (Evidence)
Entrez Gene11596 (Evidence)
UniGene3383
DFCITC1684508, TC1585993
NIA Mouse Gene IndexU017860
PDB4IM8
Consensus CDS ProjectCCDS28649.1, CCDS70795.1, CCDS70796.1
International Mouse Knockout Project StatusAger
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037074 VEGA Gene Model | MGI Sequence Detail 3075 C57BL/6J ±  kb
transcript OTTMUST00000095384 VEGA | MGI Sequence Detail 1370 Not Applicable 
polypeptide OTTMUSP00000053230 VEGA | MGI Sequence Detail 402 Not Applicable 

For the selected sequences
All sequences(142) RefSeq(19) UniProt(41)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000003828 advanced glycosylation end product-specific receptor
References
(Earliest) J:55874 Hofmann MA, et al., RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999 Jun 25;97(7):889-901
(Latest) J:215261 Nagareddy PR, et al., Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab. 2014 May 6;19(5):821-35
All references(166)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/23/2014
MGI 5.20
The Jackson Laboratory