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Ager
Gene Detail
 Symbol
Name
ID
Ager
advanced glycosylation end product-specific receptor
MGI:893592
Synonyms RAGE
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:34597862-34600936 bp, + strand
From VEGA annotation of GRCm38

  3075 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:883  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: advanced glycosylation end products receptor
Gene Tree: Ager

Human
homologs
Human Homolog AGER, advanced glycosylation end product-specific receptor
NCBI Gene ID 177
neXtProt AC  NX_Q15109
Human Synonyms  RAGE
Human Chr (Location)  6p21.3; chr6:32180968-32184322 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Homozygotes for a null allele show increased bone mass and strength, reduced osteoclast number, abnormal blood vessel healing, and altered development of nephropathy and pain perception in induced diabetes. Homozygotes for another null allele show restored diabetes-induced angiogenic responses.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Ager interacts with 203 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process calcium ion homeostasis, induction of positive chemotaxis, ...
Component axon, basal plasma membrane, ...
Function advanced glycation end-product receptor activity, high mobility group box 1 binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (81)    Tissues (49)    Images (23)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 35
RT-PCR 46
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(23) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037074 (Evidence)
Ensembl Gene ModelENSMUSG00000015452 (Evidence)
Entrez Gene11596 (Evidence)
UniGene3383
DFCITC1585993, TC1684508
NIA Mouse Gene IndexU017860
PDB4IM8
Consensus CDS ProjectCCDS28649.1, CCDS70795.1, CCDS70796.1
International Mouse Knockout Project StatusAger
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037074 VEGA Gene Model | MGI Sequence Detail 3075 C57BL/6J ±  kb
transcript OTTMUST00000095384 VEGA | MGI Sequence Detail 1370 Not Applicable 
polypeptide OTTMUSP00000053230 VEGA | MGI Sequence Detail 402 Not Applicable 

For the selected sequences
All sequences(122) RefSeq(19) UniProt(21)
Polymorphisms SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000003828 advanced glycosylation end product-specific receptor
References (Earliest) J:55874 Hofmann MA, et al., RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999 Jun 25;97(7):889-901
(Latest) J:210201 Al-Robaiy S, et al., The receptor for advanced glycation end-products supports lung tissue biomechanics. Am J Physiol Lung Cell Mol Physiol. 2013 Oct 1;305(7):L491-500
All references(156)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory