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Ager Gene Detail
Summary
  • Symbol
    Ager
  • Name
    advanced glycosylation end product-specific receptor
  • Synonyms
    RAGE
  • Feature Type
    protein coding gene
  • IDs
    MGI:893592
    NCBI Gene: 11596
  • Gene Overview
    MyGene.info: AGER
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:34597862-34600936 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3075 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.18 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    AGER, advanced glycosylation end-product specific receptor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AGER, advanced glycosylation end-product specific receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RAGE, SCARJ1
  • Links
    NCBI Gene ID: 177
    neXtProt AC: NX_Q15109
    UniProt: Q15109

  • Chr Location
    6p21.32; chr6:32180968-32185247 (-)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 5 alleles in 7 genetic backgrounds
    14 phenotypes from multigenic genotypes
    151 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show increased bone mass and strength, reduced osteoclast number, abnormal blood vessel healing, and altered development of nephropathy and pain perception in induced diabetes. Homozygotes for another null allele show restored diabetes-induced angiogenic responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037074 VEGA Gene Model | MGI Sequence Detail 3075 C57BL/6J ±  kb
    transcript OTTMUST00000095384 VEGA | MGI Sequence Detail 1370 Not Applicable  
    polypeptide OTTMUSP00000053230 VEGA | MGI Sequence Detail 402 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 24
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 239
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 17
      Phenotypes 151
    • Earliest
      J:55874 Hofmann MA, et al., RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999 Jun 25;97(7):889-901
    • Latest
      J:262686 Chen X, et al., Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice. Sci Rep. 2018 May 29;8(1):8319

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory