Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.3.0)

Enables S100 protein binding activity and advanced glycation end-product binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of long-term synaptic potentiation; and positive regulation of cytokine production. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of connective tissue replacement involved in inflammatory response wound healing; and positive regulation of macromolecule metabolic process. Located in extracellular region; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); cystic fibrosis; diabetes mellitus (multiple); kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor).

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Gene Ontology Evidence Code Abbreviations:

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