Ager Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ager
advanced glycosylation end product-specific receptor
MGI:893592

28 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ager^tm1.1Arnd/Ager^tm1.1Arnd B6.129P2-Ager^tm1.1Arnd	decreased bone resorption	J:104998
	decreased bone trabecular spacing	J:104998
	decreased circulating interleukin-6 level	J:104998
	decreased osteoclast cell number	J:104998
	increased bone mass	J:104998
	increased bone mineral content	J:104998
	increased bone mineral density of femur	J:104998
	increased bone strength	J:104998
	increased femur compact bone thickness	J:104998
	increased trabecular bone thickness	J:104998
	increased trabecular bone volume	J:104998
Ager^tm1.1Arnd/Ager^tm1.1Arnd involves: 129P2/OlaHsd	abnormal immune system physiology	J:113376
Ager^tm1.1Arnd/Ager^tm1.1Arnd involves: 129P2/OlaHsd	decreased fibroblast chemotaxis	J:159873
Ager^tm1.1Arnd/Ager^tm1.1Arnd involves: 129P2/OlaHsd * C57BL/6	abnormal kidney weight	J:82491
	abnormal mesangial matrix morphology	J:82491
	abnormal renal glomerulus basement membrane thickness	J:82491
	abnormal renal glomerulus morphology	J:82491
	abnormal thermal nociception	J:94702
	abnormal vascular smooth muscle physiology	J:82620
	abnormal vascular wound healing	J:82620
	decreased vascular smooth muscle cell proliferation	J:82620
	increased circulating glucose level	J:82491
Ager^tm1.1Hyam/Ager^tm1.1Hyam involves: 129P2/OlaHsd * C57BL/6J * CD-1	abnormal angiogenesis	J:116507
	abnormal blood homeostasis	J:116507
	abnormal cell proliferation	J:116507
	decreased apoptosis	J:116507
	decreased body weight	J:116507
	increased circulating glucose level	J:116507
Ager^tm1.1Hyam/Ager^tm1.1Hyam involves: 129P2/OlaHsd * CD-1	no abnormal phenotype detected	J:116040
Ager^tm1Arnd/Ager⁺ involves: 129P2/OlaHsd	no abnormal phenotype detected	J:69949
Ager^tm1Lex/Ager^tm1Lex involves: 129S5/SvEvBrd	no abnormal phenotype detected	J:82809
Tg(Tagln-Ager)#Yon/? C57BL/6-Tg(Tagln-Ager)#Yon	abnormal vascular smooth muscle physiology	J:82620
	abnormal vascular wound healing	J:82620
	decreased vascular smooth muscle cell proliferation	J:82620

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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