Ager^tm1.1Arnd
Targeted Allele Detail

Summary

• Symbol: Ager^tm1.1Arnd
• Name: advanced glycosylation end product-specific receptor; targeted mutation 1.1, Bernd Arnold
• MGI ID: MGI:2451038
• Synonyms: RA/EG, RA/EG^-, Rage^-, RAGE-, Rage^eGFP, Rage^flx, RAGE^-.GFP, RAGE KO
• Gene: Ager Location: Chr17:34816836-34819910 bp, + strand Genetic Position: Chr17, 18.18 cM
• Alliance: Ager^tm1.1Arnd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69949
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An EGFP reporter gene followed by a single loxP site was inserted into intron 1 in reverse transcriptional orientation to the gene. A neomycin selection gene followed by a single loxP site and a thymidine kinase promoter were inserted into intron 7. Cre mediated recombination in the germ line deleted exons 2-7 and brought the thymidine kinase promoter into proximity of the EGFP gene to activate its transcription. (J:69949)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ager^tm1.1Arnd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ager Mutation: 28 strains or lines available

References

• Original: J:69949 Constien R, et al., Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line. Genesis. 2001 May;30(1):36-44
• All: 163 reference(s)