About   Help   FAQ
Cyp11a1
Gene Detail
 Symbol
Name
ID
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
MGI:88582
Synonyms cholesterol side chain cleavage, cscc, Cyp11a, D9Ertd411e, P450scc, Scc
Feature Type protein coding gene
Genetic Map
Chromosome 9
31.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr9:58015017-58027023 bp, + strand
From NCBI annotation of GRCm38

  12007 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37347  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: cytochrome P450 CYP11B1
Gene Tree: Cyp11a1

Human
homologs
Human Homolog CYP11A1, cytochrome P450, family 11, subfamily A, polypeptide 1
NCBI Gene ID 1583
neXtProt AC  NX_P05108
Human Synonyms  CYP11A, CYPXIA1, P450SCC
Human Chr (Location)  15q23-q24; chr15:74337762-74369579 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CYP11A1
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are exhibit a steroid deficiency and die within days of birth showing signs of dehydration. Males are feminized with female external genitalia and underdeveloped gonads. Mice homozgyous for another knock-out allele exhibit abnormal adrenal development and neonatal lethality.
 
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process C21-steroid hormone biosynthetic process, cholesterol metabolic process, ...
Component membrane, mitochondrial crista, ...
Function cholesterol binding, cholesterol monooxygenase (side-chain-cleaving) activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (80 records)
Data Summary: Results (202)    Tissues (141)    Images (19)
Theiler Stages: 4, 10, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 129
RT-PCR 72
cDNA source data(71)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(84) Genomic(1) cDNA(74) Primer pair(6) Other(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000032323 (Evidence)
Entrez Gene13070 (Evidence)
UniGene302865
DFCITC1578831, TC1604914
DoTSDT.101724049, DT.40151364, DT.533628
NIA Mouse Gene IndexU010560, U010561
EC1.14.15.6
Consensus CDS ProjectCCDS40653.1
International Mouse Knockout Project StatusCyp11a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13070 NCBI Gene Model | MGI Sequence Detail 12007 C57BL/6J ±  kb
transcript NM_019779 RefSeq | MGI Sequence Detail 1774 C57BL/6 
polypeptide Q9QZ82 UniProt | EBI | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006096 cytochrome P450 11A1, mitochondrial
Graphical View of Protein Domain Structure
References (Earliest) J:26017 Perkins LM, et al., Quantification of P450scc, P450(17) alpha, and iron sulfur protein reductase in Leydig cells and adrenals of inbred strains of mice. Endocrinology. 1988 Dec;123(6):2675-82
(Latest) J:204550 Fujimoto Y, et al., Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development. Dev Cell. 2013 Aug 26;26(4):416-30
All references(135)
Other
accession IDs
MGD-MRK-2291, MGI:1196317

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory