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Cyp11a1
Gene Detail
Symbol

Name
ID
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
MGI:88582
Synonyms
cholesterol side chain cleavage, cscc, Cyp11a, D9Ertd411e, P450scc, Scc
Feature Type
protein coding gene
Genetic Map
Chromosome 9
31.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr9:58006411-58027023 bp, + strand
From VEGA annotation of GRCm38

  20613 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37347  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CYP11A1
Protein SuperFamily: cytochrome P450 CYP11B1
Gene Tree: Cyp11a1

Human
homologs
CYP11A1, cytochrome P450, family 11, subfamily A, polypeptide 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1583
neXtProt AC: NX_P05108

Human Synonyms: CYP11A, CYPXIA1, P450SCC

Human Chr (Location): 15q23-q24; chr15:74337762-74367740 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CYP11A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(6) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are exhibit a steroid deficiency and die within days of birth showing signs of dehydration. Males are feminized with female external genitalia and underdeveloped gonads. Mice homozgyous for another knock-out allele exhibit abnormal adrenal development and neonatal lethality.
 
Interactions
Cyp11a1 interacts with 42 markers (Mir26a-1, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (88 records)
Data Summary: Results (252)    Tissues (151)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 129
RT-PCR 121
cDNA source data(71)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100495360 ; ZFIN cyp11a1, cyp11a2    NEW 
Molecular
reagents
All nucleic(87) Genomic(1) cDNA(74) Primer pair(9) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000045946 (Evidence)
Ensembl Gene Model ENSMUSG00000032323 (Evidence)
Entrez Gene 13070 (Evidence)
UniGene 302865
DFCI TC1578831, TC1604914
DoTS DT.101724049, DT.40151364, DT.533628
NIA Mouse Gene Index U010560, U010561
EC 1.14.15.6
Consensus CDS Project CCDS40653.1
International Mouse Phenotyping Consortium Status Cyp11a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045946 VEGA Gene Model | MGI Sequence Detail 20613 C57BL/6J ±  kb
transcript OTTMUST00000120042 VEGA | MGI Sequence Detail 2120 Not Applicable 
polypeptide OTTMUSP00000066597 VEGA | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006096 cytochrome P450 11A1, mitochondrial
References
(Earliest) J:26017 Perkins LM, et al., Quantification of P450scc, P450(17) alpha, and iron sulfur protein reductase in Leydig cells and adrenals of inbred strains of mice. Endocrinology. 1988 Dec;123(6):2675-82
(Latest) J:220734 Zhang L, et al., Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4003-8
All references(145)
Other
accession IDs
MGD-MRK-2291, MGI:1196317

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory