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Creb1
Gene Detail
Symbol

Name
ID
Creb1
cAMP responsive element binding protein 1
MGI:88494
Synonyms
2310001E10Rik, 3526402H21Rik, Creb, Creb-1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
32.74 cM, cytoband C1/C5
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr1:64532645-64604548 bp, + strand
From VEGA annotation of GRCm38

  71904 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cAMP response element-binding protein (CREB)
Gene Tree: Creb1

Human
homologs
Human Homolog CREB1, cAMP responsive element binding protein 1
NCBI Gene ID 1385
neXtProt AC  NX_P16220
Human Synonyms  CREB
Human Chr (Location)  2q34; chr2:207529892-207605560 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CREB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(95) : Gene trapped(85) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for alleles lacking some or all isotypes exhibit a range of defects involving circadian rhythms, axonal growth, sensory neuron survival, long-term memory, fear conditioning, body size, respiration, and neonatal viability.
 
Interactions
Creb1 interacts with 534 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process axonogenesis, cell differentiation, ...
Component chromatin, mitochondrion, ...
Function cAMP response element binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (54)    Tissues (26)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 29
Western blot 19
cDNA source data(166)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(184) Genomic(13) cDNA(170) Primer pair(1)
Microarray probesets(14)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047617 VEGA Gene Model | MGI Sequence Detail 71904 C57BL/6J ±  kb
transcript OTTMUST00000122770 VEGA | MGI Sequence Detail 1260 Not Applicable 
polypeptide OTTMUSP00000067240 VEGA | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(131) RefSeq(18) UniProt(15)
Polymorphisms
RFLP(8) : SNPs within 2kb(356 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR001630 cAMP response element binding (CREB) protein
InterPro IPR003102 Coactivator CBP, pKID
Protein Ontology PR:000005854 cyclic AMP-responsive element-binding protein 1
References
(Earliest) J:10525 Capetanaki Y, et al., Mouse vimentin: structural relationship to fos, jun, CREB and tpr. Oncogene. 1990 May;5(5):645-55
(Latest) J:211601 Naqvi S, et al., CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling. Biochem J. 2014 Mar 15;458(3):469-79
All references(233)
Other
accession IDs
MGD-MRK-2134, MGD-MRK-2135, MGD-MRK-2136, MGI:1913601, MGI:1913933, MGI:2138519

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory