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Creb1
Gene Detail
Symbol

Name
ID
Creb1
cAMP responsive element binding protein 1
MGI:88494
Synonyms
2310001E10Rik, 3526402H21Rik, Creb, Creb-1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
32.74 cM, cytoband C1/C5
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr1:64532645-64604548 bp, + strand
From VEGA annotation of GRCm38

  71904 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CREB1
Protein SuperFamily: cAMP response element-binding protein (CREB)
Gene Tree: Creb1

Human
homologs
CREB1, cAMP responsive element binding protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1385
neXtProt AC: NX_P16220

Human Synonyms: CREB

Human Chr (Location): 2q34; chr2:207529892-207605560 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CREB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(96) : Gene trapped(85) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for alleles lacking some or all isotypes exhibit a range of defects involving circadian rhythms, axonal growth, sensory neuron survival, long-term memory, fear conditioning, body size, respiration, and neonatal viability.
 
Interactions
Creb1 interacts with 533 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (75 annotations)
Process axonogenesis, cell differentiation, ...
Component ATF4-CREB1 transcription factor complex, chromatin, ...
Function cAMP response element binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (76)    Tissues (39)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 29
Western blot 31
RT-PCR 3
cDNA source data(166)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA CREB1 ; Xenbase creb1 ; ZFIN creb1a    NEW 
Molecular
reagents
All nucleic(185) Genomic(13) cDNA(170) Primer pair(2)
Microarray probesets(14)
Other database
links
VEGA Gene Model OTTMUSG00000047617 (Evidence)
Ensembl Gene Model ENSMUSG00000025958 (Evidence)
Entrez Gene 12912 (Evidence)
UniGene 422634
DFCI TC1578445, TC1581892, TC1588408, TC1592833, TC1636325, TC1658254, TC1680019, TC1737053, TC1778717
DoTS DT.101374061, DT.492734, DT.55159207, DT.60103826, DT.91408253, DT.91437804, DT.97413151, DT.97413152, DT.97413153
PDB 1DH3
Consensus CDS Project CCDS15004.1, CCDS15005.1, CCDS48280.1
International Mouse Phenotyping Consortium Status Creb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047617 VEGA Gene Model | MGI Sequence Detail 71904 C57BL/6J ±  kb
transcript OTTMUST00000122766 VEGA | MGI Sequence Detail 5009 Not Applicable 
polypeptide OTTMUSP00000067237 VEGA | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(129) RefSeq(22) UniProt(9)
Polymorphisms
RFLP(8) : SNPs within 2kb(356 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR001630 cAMP response element binding (CREB) protein
InterPro IPR003102 Coactivator CBP, pKID
Protein Ontology PR:000005854 cyclic AMP-responsive element-binding protein 1
References
(Earliest) J:10525 Capetanaki Y, et al., Mouse vimentin: structural relationship to fos, jun, CREB and tpr. Oncogene. 1990 May;5(5):645-55
(Latest) J:221803 Koo JW, et al., Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area. Nat Neurosci. 2015 Mar;18(3):415-22
All references(241)
Other
accession IDs
MGD-MRK-2134, MGD-MRK-2135, MGD-MRK-2136, MGI:1913601, MGI:1913933, MGI:2138519

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory