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Creb1 Gene Detail
Summary
  • Symbol
    Creb1
  • Name
    cAMP responsive element binding protein 1
  • Synonyms
    2310001E10Rik, 3526402H21Rik, Creb, Creb-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88494
    NCBI Gene: 12912
  • Gene Overview
    MyGene.info: CREB1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:64532645-64604548 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71904 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 32.74 cM, cytoband C1/C5
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    CREB1, cAMP responsive element binding protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CREB1, cAMP responsive element binding protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CREB, CREB-1
  • Links
    NCBI Gene ID: 1385
    neXtProt AC: NX_P16220
    UniProt: P16220

  • Chr Location
    2q33.3; chr2:207529892-207605989 (+)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 7 alleles in 6 genetic backgrounds
    61 phenotypes from multigenic genotypes
    3 images
    105 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for alleles lacking some or all isotypes exhibit a range of defects involving circadian rhythms, axonal growth, sensory neuron survival, long-term memory, fear conditioning, body size, respiration, and neonatal viability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000047617 VEGA Gene Model | MGI Sequence Detail 71904 C57BL/6J ±  kb
    transcript OTTMUST00000122766 VEGA | MGI Sequence Detail 5009 Not Applicable  
    polypeptide OTTMUSP00000067237 VEGA | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      354 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 188
      Genomic 13
      cDNA 172
      Primer pair 2
      Other 1

      Microarray probesets 14
    Other
    Accession IDs
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    MGD-MRK-2134, MGD-MRK-2135, MGD-MRK-2136, MGI:1913601, MGI:1913933, MGI:2138519
    References
    more
    • Summaries
      All 349
      Developmental Gene Expression 52
      Diseases 1
      Gene Ontology 34
      Phenotypes 105
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:257476 Ji Y, et al., IGF1 affects macrophage invasion and activation and TNF-alpha production in the sciatic nerves of female SOD1G93A mice. Neurosci Lett. 2018 Mar 6;668:1-6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory