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Creb1
Gene Detail
 Symbol
Name
ID
Creb1
cAMP responsive element binding protein 1
MGI:88494
Synonyms 2310001E10Rik, 3526402H21Rik, Creb, Creb-1
Feature Type protein coding gene
Genetic Map
Chromosome 1
32.74 cM, cytoband C1/C5
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr1:64532645-64604548 bp, + strand
From VEGA annotation of GRCm38

  71904 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cAMP response element-binding protein (CREB)
Gene Tree: Creb1

Human
homologs
Human Homolog CREB1, cAMP responsive element binding protein 1
NCBI Gene ID 1385
neXtProt AC  NX_P16220
Human Synonyms  CREB
Human Chr (Location)  2q34; chr2:207529892-207605560 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CREB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(95) : Gene trapped(85) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for alleles lacking some or all isotypes exhibit a range of defects involving circadian rhythms, axonal growth, sensory neuron survival, long-term memory, fear conditioning, body size, respiration, and neonatal viability.
 
Interactions
Creb1 interacts with 534 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (73 annotations)
Process axonogenesis, cell differentiation, ...
Component chromatin, mitochondrion, ...
Function cAMP response element binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (54)    Tissues (26)    Images (2)
Theiler Stages: 15, 17, 19, 21, 23, 26, 27
Assay TypeResults
Immunohistochemistry 6
RNA in situ 29
Western blot 19
cDNA source data(166)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(184) Genomic(13) cDNA(170) Primer pair(1)
Microarray probesets(14)
Other database
links
VEGA Gene ModelOTTMUSG00000047617 (Evidence)
Ensembl Gene ModelENSMUSG00000025958 (Evidence)
Entrez Gene12912 (Evidence)
UniGene422634
DFCITC1578445, TC1581892, TC1588408, TC1592833, TC1636325, TC1658254, TC1680019, TC1737053, TC1778717
DoTSDT.101374061, DT.492734, DT.55159207, DT.60103826, DT.91408253, DT.91437804, DT.97413151, DT.97413152, DT.97413153
PDB1DH3
Consensus CDS ProjectCCDS15004.1, CCDS15005.1, CCDS48280.1
International Mouse Knockout Project StatusCreb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047617 VEGA Gene Model | MGI Sequence Detail 71904 C57BL/6J ±  kb
transcript OTTMUST00000122770 VEGA | MGI Sequence Detail 1260 Not Applicable 
polypeptide OTTMUSP00000067240 VEGA | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(111) RefSeq(18) UniProt(7)
Polymorphisms RFLP(8) : SNPs within 2kb(356 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR001630 cAMP response element binding (CREB) protein
InterPro IPR003102 Coactivator CBP, pKID
Protein Ontology PR:000005854 cyclic AMP-responsive element-binding protein 1
References (Earliest) J:10525 Capetanaki Y, et al., Mouse vimentin: structural relationship to fos, jun, CREB and tpr. Oncogene. 1990 May;5(5):645-55
(Latest) J:211601 Naqvi S, et al., CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling. Biochem J. 2014 Mar 15;458(3):469-79
All references(233)
Other
accession IDs
MGD-MRK-2134, MGD-MRK-2135, MGD-MRK-2136, MGI:1913601, MGI:1913933, MGI:2138519

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory