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Crabp2 Gene Detail
Summary
  • Symbol
    Crabp2
  • Name
    cellular retinoic acid binding protein II
  • Synonyms
    Crabp-2, CrabpII
  • Feature Type
    protein coding gene
  • IDs
    MGI:88491
    NCBI Gene: 12904
  • Gene Overview
    MyGene.info: CRABP2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:87948693-87953372 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.78 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88491
protein coding gene Chr3:87948666-87953376 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027376
protein coding gene Chr3:88081869-88086575 (+)
A/J MGP_AJ_G0027340
protein coding gene Chr3:85091792-85096503 (+)
AKR/J MGP_AKRJ_G0027306
protein coding gene Chr3:87184993-87189715 (+)
BALB/cJ MGP_BALBcJ_G0027349
protein coding gene Chr3:85186040-85190766 (+)
C3H/HeJ MGP_C3HHeJ_G0027092
protein coding gene Chr3:87455623-87460319 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027795
protein coding gene Chr3:91323265-91327975 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025148
protein coding gene Chr3:80714763-80719483 (+)
CAST/EiJ MGP_CASTEiJ_G0026538
protein coding gene Chr3:87665702-87672508 (+)
CBA/J MGP_CBAJ_G0027067
protein coding gene Chr3:94414025-94418756 (+)
DBA/2J MGP_DBA2J_G0027203
protein coding gene Chr3:84582824-84587542 (+)
FVB/NJ MGP_FVBNJ_G0027172
protein coding gene Chr3:82855539-82860250 (+)
LP/J MGP_LPJ_G0027311
protein coding gene Chr3:89047917-89052620 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027191
protein coding gene Chr3:100659952-100664694 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027853
protein coding gene Chr3:86940379-86944905 (+)
PWK/PhJ MGP_PWKPhJ_G0026271
protein coding gene Chr3:84378481-84383390 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026089
protein coding gene Chr3:86120587-86125306 (+)
WSB/EiJ MGP_WSBEiJ_G0026618
protein coding gene Chr3:87298805-87304330 (+)



Homology
more
  • Human Ortholog
    CRABP2, cellular retinoic acid binding protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRABP2, cellular retinoic acid binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRABP-II, RBP6
  • Links
    NCBI Gene ID: 1382
    neXtProt AC: NX_P29373
    UniProt: P29373

  • Chr Location
    1q23.1; chr1:156699606-156712900 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations may exhibit an additional postaxial digit, usually on a single forepaw. Penetrance is dependent on the genetic background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12904 NCBI Gene Model | MGI Sequence Detail 4680 C57BL/6J ±  kb
    transcript NM_007759 RefSeq | MGI Sequence Detail 900 C57BL/6  
    polypeptide P22935 UniProt | EBI | MGI Sequence Detail 138 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 76
      Genomic 1
      cDNA 68
      Primer pair 4
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2127, MGD-MRK-2129, MGI:2139840
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 45
      Diseases 1
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:20074 Giguere V, et al., Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein. Proc Natl Acad Sci U S A. 1990 Aug;87(16):6233-7
    • Latest
      J:257918 Massimino L, et al., TBR2 antagonizes retinoic acid dependent neuronal differentiation by repressing Zfp423 during corticogenesis. Dev Biol. 2018 Feb 15;434(2):231-248

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory