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Crabp2
Gene Detail
Symbol

Name
ID
Crabp2
cellular retinoic acid binding protein II
MGI:88491
Synonyms
Crabp-2, CrabpII
Feature Type
protein coding gene
Genetic Map
Chromosome 3
38.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:87948666-87953376 bp, + strand
From VEGA annotation of GRCm38

  4711 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1415  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: lipid binding protein, FABP type
Gene Tree: Crabp2

Human
homologs
Human Homolog CRABP2, cellular retinoic acid binding protein 2
NCBI Gene ID 1382
neXtProt AC  NX_P29373
Human Synonyms  CRABP-II, RBP6
Human Chr (Location)  1q21.3; chr1:156699606-156713174 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations may exhibit an additional postaxial digit, usually on a single forepaw. Penetrance is dependent on the genetic background.
 
Interactions
Crabp2 interacts with 37 markers (Mir16-2, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process embryonic forelimb morphogenesis, retinoic acid metabolic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function cyclin binding, lipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (42 records)
Data Summary: Results (546)    Tissues (220)    Images (70)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 487
Northern blot 24
RT-PCR 12
RNase protection 18
cDNA source data(66)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(71) Genomic(1) cDNA(66) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027199 (Evidence)
Ensembl Gene ModelENSMUSG00000004885 (Evidence)
Entrez Gene12904 (Evidence)
UniGene4757
DFCITC1577271
DoTSDT.492355
NIA Mouse Gene IndexU003416
Consensus CDS ProjectCCDS17460.1
International Mouse Knockout Project StatusCrabp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027199 VEGA Gene Model | MGI Sequence Detail 4711 C57BL/6J ±  kb
transcript OTTMUST00000067255 VEGA | MGI Sequence Detail 931 Not Applicable 
polypeptide OTTMUSP00000033811 VEGA | MGI Sequence Detail 138 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012674 Calycin
InterPro IPR011038 Calycin-like
InterPro IPR000463 Cytosolic fatty-acid binding
InterPro IPR000566 Lipocalin/cytosolic fatty-acid binding protein domain
Protein Ontology PR:000005844 cellular retinoic acid-binding protein 2
References
(Earliest) J:20074 Giguere V, et al., Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein. Proc Natl Acad Sci U S A. 1990 Aug;87(16):6233-7
(Latest) J:200551 Paschaki M, et al., Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling. PLoS One. 2013;8(4):e62274
All references(83)
Other
accession IDs
MGD-MRK-2127, MGD-MRK-2129, MGI:2139840

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory