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Crabp2 Gene Detail
Summary
  • Symbol
    Crabp2
  • Name
    cellular retinoic acid binding protein II
  • Synonyms
    Crabp-2, CrabpII
  • Feature Type
    protein coding gene
  • IDs
    MGI:88491
    NCBI Gene: 12904
  • Gene Overview
    MyGene.info: CRABP2
Location & Maps
more
  • Sequence Map
    Chr3:87948666-87953376 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4711 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.78 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CRABP2, cellular retinoic acid binding protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRABP2, cellular retinoic acid binding protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRABP-II, RBP6
  • Links
    NCBI Gene ID: 1382
    neXtProt AC: NX_P29373

  • Chr Location
    1q21.3; chr1:156699606-156705816 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Crabp2
  • Incidental Mutations
Homozygotes for targeted null mutations may exhibit an additional postaxial digit, usually on a single forepaw. Penetrance is dependent on the genetic background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027199 VEGA Gene Model | MGI Sequence Detail 4711 C57BL/6J ±  kb
transcript OTTMUST00000067255 VEGA | MGI Sequence Detail 931 Not Applicable  
polypeptide OTTMUSP00000033811 VEGA | MGI Sequence Detail 138 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    43 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005844 cellular retinoic acid-binding protein 2
  • InterPro Domains
    IPR012674 Calycin
    IPR011038 Calycin-like
    IPR031281 Cellular retinoic acid-binding protein 2
    IPR000463 Cytosolic fatty-acid binding
    IPR031259 Intracellular lipid binding protein
    IPR000566 Lipocalin/cytosolic fatty-acid binding domain
Molecular
Reagents
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  • All nucleic 71
    Genomic 1
    cDNA 66
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-2127, MGD-MRK-2129, MGI:2139840
References
more
  • Summaries
    All 80
    Developmental Gene Expression 43
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:20074 Giguere V, et al., Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein. Proc Natl Acad Sci U S A. 1990 Aug;87(16):6233-7
  • Latest
    J:229100 Goto M, et al., Hes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development. Brain Res. 2015 Nov 2;1625:206-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory