About   Help   FAQ
Cntf Gene Detail
Summary
  • Symbol
    Cntf
  • Name
    ciliary neurotrophic factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:88439
    NCBI Gene: 12803
  • Gene Overview
    MyGene.info: CNTF
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:12763660-12765632 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 8.73 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88439
protein coding gene Chr19:12763528-12765632 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024914
protein coding gene Chr19:10248471-10250443 (-)
A/J MGP_AJ_G0024890
protein coding gene Chr19:9600090-9602062 (-)
AKR/J MGP_AKRJ_G0024862
protein coding gene Chr19:10075258-10077230 (-)
BALB/cJ MGP_BALBcJ_G0024889
protein coding gene Chr19:9610738-9612710 (-)
C3H/HeJ MGP_C3HHeJ_G0024653
protein coding gene Chr19:9966066-9968038 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025338
protein coding gene Chr19:10797767-10799739 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022764
protein coding gene Chr19:10232872-10234846 (-)
CAST/EiJ MGP_CASTEiJ_G0024122
protein coding gene Chr19:9529468-9531439 (-)
CBA/J MGP_CBAJ_G0024627
protein coding gene Chr19:10895525-10897497 (-)
DBA/2J MGP_DBA2J_G0024759
protein coding gene Chr19:9659661-9661633 (-)
FVB/NJ MGP_FVBNJ_G0024722
protein coding gene Chr19:9665307-9667279 (-)
LP/J MGP_LPJ_G0024842
protein coding gene Chr19:10327336-10329308 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024749
protein coding gene Chr19:10659285-10661257 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025386
protein coding gene Chr19:10059134-10061106 (-)
PWK/PhJ MGP_PWKPhJ_G0023871
protein coding gene Chr19:9113052-9115020 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023675
protein coding gene Chr19:9218477-9220439 (-)
WSB/EiJ MGP_WSBEiJ_G0024190
protein coding gene Chr19:9915064-9917036 (-)



Homology
more
  • Human Ortholog
    CNTF, ciliary neurotrophic factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CNTF, ciliary neurotrophic factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HCNTF
  • Links
    NCBI Gene ID: 1270
    neXtProt AC: NX_P26441
    UniProt: P26441

  • Chr Location
    11q12.1; chr11:58622673-58625733 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display progressive atrophy and degeneration of motor neurons in adulthood and reduced muscle strength. Another allele does not display any overt abnormalities at birth, however motor neuron sprouting does not occur after damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079415 Ensembl Gene Model | MGI Sequence Detail 1973 C57BL/6J ±  kb
    transcript ENSMUST00000112933 Ensembl | MGI Sequence Detail 1073 Not Applicable  
    polypeptide ENSMUSP00000108555 Ensembl | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 10
      Primer pair 3
      Other 1
    Other
    Accession IDs
    less
    MGD-MRK-2043, MGI:2147531
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 17
      Gene Ontology 10
      Phenotypes 33
    • Earliest
      J:14942 Kaupmann K, et al., The gene for ciliary neurotrophic factor (CNTF) maps to murine Chromosome 19 and its expression is not affected in the hereditary motoneuron disease 'Wobbler' of the mouse. Eur J Neurosci. 1991;3:1182-86
    • Latest
      J:257508 Kawamura Y, et al., Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain. FEBS Lett. 2017 Nov;591(22):3709-3720

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory