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Cntf Gene Detail
Summary
  • Symbol
    Cntf
  • Name
    ciliary neurotrophic factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:88439
    NCBI Gene: 12803
  • Gene Overview
    MyGene.info: CNTF
Location & Maps
more
  • Sequence Map
    Chr19:12763660-12765632 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1973 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 8.73 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CNTF, ciliary neurotrophic factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CNTF, ciliary neurotrophic factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HCNTF
  • Links
    NCBI Gene ID: 1270
    neXtProt AC: NX_P26441

  • Chr Location
    11q12.2; chr11:58622673-58625733 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Targeted
    6
Mice homozygous for a disruption in this gene display progressive atrophy and degeneration of motor neurons in adulthood and reduced muscle strength. Another allele does not display any overt abnormalities at birth, however motor neuron sprouting does not occur after damage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024775 VEGA Gene Model | MGI Sequence Detail 1973 C57BL/6J ±  kb
transcript OTTMUST00000061010 VEGA | MGI Sequence Detail 1073 Not Applicable  
polypeptide OTTMUSP00000029848 VEGA | MGI Sequence Detail 198 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    29 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005663 ciliary neurotrophic factor
  • InterPro Domains
    IPR000151 Ciliary neurotrophic factor, CNTF
    IPR012351 Four-helical cytokine, core
    IPR009079 Four-helical cytokine-like, core
Molecular
Reagents
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  • All nucleic 12
    Genomic 1
    cDNA 9
    Primer pair 2
Other
Accession IDs
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MGD-MRK-2043, MGI:2147531
References
more
  • Summaries
    All 94
    Developmental Gene Expression 14
    Gene Ontology 10
    Phenotypes 33
  • Earliest
    J:14297 Kaupmann K, et al., The gene for ciliary neurotrophic factor (CNTF) maps to Chromosome 19 of the mouse. Mouse Genome. 1991;89:246
  • Latest
    J:224034 Zhou Q, et al., Ciliary neurotrophic factor promotes the activation of corneal epithelial stem/progenitor cells and accelerates corneal epithelial wound healing. Stem Cells. 2015 May;33(5):1566-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory