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C3
Gene Detail
Symbol

Name
ID
C3
complement component 3
MGI:88227
STS
Synonyms
acylation stimulating protein, complement factor 3, Plp
Feature Type
protein coding gene
Genetic Map
Chromosome 17
29.72 cM, cytoband E1-E3
Detailed Genetic Map ± 1 cM


Mapping data(41)
Sequence Map
Chr17:57203970-57228136 bp, - strand
From VEGA annotation of GRCm38

  24167 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68031  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 7 western clawed frog; 6 zebrafish

HCOP human homology predictions: C3
Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: C3

Human
homologs
C3, complement component 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 718
neXtProt AC: NX_P01024

Human Synonyms: AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p

Human Chr (Location): 19p13.3-p13.2; chr19:6677835-6720682 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human C3

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice exhibit abnormal immune responses, including increased mortality upon bacterial infection and decreased inflammatory response.
 
Interactions
C3 interacts with 45 markers (Mir7b, Mir22, Mir106b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process blood coagulation, complement activation, ...
Component blood microparticle, extracellular exosome, ...
Function C5L2 anaphylatoxin chemotactic receptor binding, cofactor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (85)    Tissues (43)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 22
Northern blot 5
Western blot 4
RT-PCR 44
cDNA source data(422)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase c3    NEW 
Molecular
reagents
All nucleic(428) Genomic(1) cDNA(423) Primer pair(1) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000042133 (Evidence)
Ensembl Gene Model ENSMUSG00000024164 (Evidence)
Entrez Gene 12266 (Evidence)
UniGene 19131
DFCI TC1573451
DoTS DT.101181954, DT.101377392, DT.55107305, DT.94376167
NIA Mouse Gene Index U037974
Consensus CDS Project CCDS37670.1
International Mouse Phenotyping Consortium Status C3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042133 VEGA Gene Model | MGI Sequence Detail 24167 C57BL/6J ±  kb
transcript OTTMUST00000110561 VEGA | MGI Sequence Detail 5136 Not Applicable 
polypeptide OTTMUSP00000061702 VEGA | MGI Sequence Detail 1663 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(6)
Polymorphisms
RFLP(7) : SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001599 Alpha-2-macroglobulin
InterPro IPR019742 Alpha-2-macroglobulin, conserved site
InterPro IPR002890 Alpha-2-macroglobulin, N-terminal
InterPro IPR011625 Alpha-2-macroglobulin, N-terminal 2
InterPro IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro IPR009048 Alpha-macroglobulin, receptor-binding
InterPro IPR011626 A-macroglobulin complement component
InterPro IPR018081 Anaphylatoxin
InterPro IPR000020 Anaphylatoxin/fibulin
InterPro IPR001840 Complement C3a/C4a/C5a anaphylatoxin
InterPro IPR001134 Netrin domain
InterPro IPR018933 Netrin module, non-TIMP type
InterPro IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000004900 complement C3
References
(Earliest) J:5960 Da Silva FP, et al., Murine complement component 3: genetic variation and linkage to H-2. Proc Natl Acad Sci U S A. 1978 Feb;75(2):963-5
(Latest) J:220353 Xing EM, et al., The effect of Tlr4 and/or C3 deficiency and of neonatal gene therapy on skeletal disease in mucopolysaccharidosis VII mice. Mol Genet Metab. 2015 Feb;114(2):209-16
All references(387)
Other
accession IDs
MGD-MRK-1700, MGI:2146809

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory