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C3
Gene Detail
 Symbol
Name
ID
C3
complement component 3
MGI:88227
STS D17Mit20
Synonyms acylation stimulating protein, complement factor 3, Plp
Feature Type protein coding gene
Genetic Map
Chromosome 17
29.72 cM, cytoband E1-E3
Detailed Genetic Map ± 1 cM


Mapping data(41)
Sequence Map
Chr17:57203970-57228136 bp, - strand
From VEGA annotation of GRCm38

  24167 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68031  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 6 zebrafish

Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: C3

Human
homologs
Human Homolog C3, complement component 3
NCBI Gene ID 718
neXtProt AC  NX_P01024
Human Synonyms  AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p
Human Chr (Location)  19p13.3-p13.2; chr19:6677835-6720651 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human C3
Alleles
and
phenotypes
All alleles(10) : Targeted(7) Other(3)
 
Homozygous mutant mice exhibit abnormal immune responses, including increased mortality upon bacterial infection and decreased inflammatory response.
 
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process blood coagulation, complement activation, ...
Component blood microparticle, extracellular region, ...
Function C5L2 anaphylatoxin chemotactic receptor binding, cofactor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (85)    Tissues (39)    Images (23)
Theiler Stages: 11, 13, 15, 16, 17, 18, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 22
Northern blot 5
Western blot 4
RT-PCR 44
cDNA source data(422)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(428) Genomic(1) cDNA(423) Primer pair(1) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000042133 (Evidence)
Ensembl Gene ModelENSMUSG00000024164 (Evidence)
Entrez Gene12266 (Evidence)
UniGene19131
DFCITC1573451
DoTSDT.101181954, DT.101377392, DT.55107305, DT.94376167
NIA Mouse Gene IndexU037974
Consensus CDS ProjectCCDS37670.1
International Mouse Knockout Project StatusC3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042133 VEGA Gene Model | MGI Sequence Detail 24167 C57BL/6J ±  kb
transcript OTTMUST00000110561 VEGA | MGI Sequence Detail 5136 Not Applicable 
polypeptide OTTMUSP00000061702 VEGA | MGI Sequence Detail 1663 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(6)
Polymorphisms RFLP(7) : SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001599 Alpha-2-macroglobulin
InterPro IPR019742 Alpha-2-macroglobulin, conserved site
InterPro IPR002890 Alpha-2-macroglobulin, N-terminal
InterPro IPR011625 Alpha-2-macroglobulin, N-terminal 2
InterPro IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro IPR009048 Alpha-macroglobulin, receptor-binding
InterPro IPR011626 A-macroglobulin complement component
InterPro IPR018081 Anaphylatoxin
InterPro IPR000020 Anaphylatoxin/fibulin
InterPro IPR001840 Complement C3a/C4a/C5a anaphylatoxin
InterPro IPR001134 Netrin domain
InterPro IPR018933 Netrin module, non-TIMP type
InterPro IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000004900 complement C3
References (Earliest) J:5960 Da Silva FP, et al., Murine complement component 3: genetic variation and linkage to H-2. Proc Natl Acad Sci U S A. 1978 Feb;75(2):963-5
(Latest) J:206648 Baudino L, et al., C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1503-8
All references(375)
Other
accession IDs
MGD-MRK-1700, MGI:2146809

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory