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C3 Gene Detail
Summary
  • Symbol
    C3
  • Name
    complement component 3
  • Synonyms
    acylation stimulating protein, complement factor 3, Plp
  • Feature Type
    protein coding gene
  • IDs
    MGI:88227
    NCBI Gene: 12266
  • Gene Overview
    MyGene.info: C3
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57203970-57228136 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.72 cM, cytoband E1-E3
  • Mapping Data
    41 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88227
protein coding gene Chr17:57203967-57228136 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023959
protein coding gene Chr17:58971369-59001221 (-)
A/J MGP_AJ_G0023917
protein coding gene Chr17:57335091-57359217 (-)
AKR/J MGP_AKRJ_G0023886
protein coding gene Chr17:58062465-58086584 (-)
BALB/cJ MGP_BALBcJ_G0023918
protein coding gene Chr17:57172948-57197061 (-)
C3H/HeJ MGP_C3HHeJ_G0023682
protein coding gene Chr17:58779408-58803383 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024364
protein coding gene Chr17:61267678-61293597 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021810
protein coding gene Chr17:53802779-53828080 (-)
CAST/EiJ MGP_CASTEiJ_G0023164
protein coding gene Chr17:59088416-59114439 (-)
CBA/J MGP_CBAJ_G0023658
protein coding gene Chr17:63662063-63689043 (-)
DBA/2J MGP_DBA2J_G0023786
protein coding gene Chr17:56025716-56050095 (-)
FVB/NJ MGP_FVBNJ_G0023752
protein coding gene Chr17:55604214-55628264 (-)
LP/J MGP_LPJ_G0023868
protein coding gene Chr17:59655620-59680444 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023780
protein coding gene Chr17:63092197-63116217 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024408
protein coding gene Chr17:58423657-58448824 (-)
PWK/PhJ MGP_PWKPhJ_G0022910
protein coding gene Chr17:55396411-55420853 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022721
protein coding gene Chr17:55197617-55224500 (-)
WSB/EiJ MGP_WSBEiJ_G0023230
protein coding gene Chr17:59059143-59083996 (-)



Homology
more
  • Human Ortholog
    C3, complement C3
  • Vertebrate Orthologs
    21
  • Human Ortholog
    C3, complement C3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p
  • Links
    NCBI Gene ID: 718
    neXtProt AC: NX_P01024
    UniProt: P01024

  • Chr Location
    19p13.3; chr19:6677835-6720682 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with C3 mouse models; 3 with human C3 associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    84 phenotypes from 4 alleles in 11 genetic backgrounds
    40 phenotypes from multigenic genotypes
    3 images
    316 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit abnormal immune responses, including increased mortality upon bacterial infection and decreased inflammatory response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024164 Ensembl Gene Model | MGI Sequence Detail 24167 C57BL/6J ±  kb
    transcript ENSMUST00000024988 Ensembl | MGI Sequence Detail 5136 Not Applicable  
    polypeptide ENSMUSP00000024988 Ensembl | MGI Sequence Detail 1663 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 430
      Genomic 1
      cDNA 424
      Primer pair 2
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1700, MGI:2146809
    References
    more
    • Summaries
      All 456
      Developmental Gene Expression 12
      Diseases 3
      Gene Ontology 16
      Phenotypes 316
    • Earliest
      J:5960 Da Silva FP, et al., Murine complement component 3: genetic variation and linkage to H-2. Proc Natl Acad Sci U S A. 1978 Feb;75(2):963-5
    • Latest
      J:266018 Medler TR, et al., Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy. Cancer Cell. 2018 Oct 8;34(4):561-578.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory