C3
Gene Detail

Symbol Name ID

C3 complement component 3 MGI:88227

STS

D17Mit20

Synonyms

acylation stimulating protein, complement factor 3, Plp

Feature Type

protein coding gene

Genetic Map

Chromosome 17

29.72 cM, cytoband E1-E3
Detailed Genetic Map ± 1 cM


Mapping data(41)

Sequence Map

Chr17:57203970-57228136 bp, - strand From VEGA annotation of GRCm38   24167 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68031  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 6 zebrafish

Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: C3

Human homologs

Human Homolog		C3, complement component 3
NCBI Gene ID		718
neXtProt AC		NX_P01024
Human Synonyms		AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1
Human Chr (Location)		19p13.3-p13.2; chr19:6677846-6720662 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human C3

Alleles and phenotypes

All alleles(9) : Targeted(6) Other(3)
 

Homozygous mutant mice exhibit abnormal immune responses, including increased mortality upon bacterial infection and decreased inflammatory response.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	blood coagulation, complement activation, ...
Component	extracellular region, extracellular space, ...
Function	C5L2 anaphylatoxin chemotactic receptor binding, cofactor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (85)    Tissues (39)    Images (23)
Theiler Stages: 11, 13, 15, 16, 17, 18, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	22
Northern blot	5
Western blot	4
RT-PCR	44

cDNA source data(422)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(428) Genomic(1) cDNA(423) Primer pair(1) Other(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000042133 (Evidence)
Ensembl Gene Model	ENSMUSG00000024164 (Evidence)
Entrez Gene	12266 (Evidence)
UniGene	19131
DFCI	TC1573451
DoTS	DT.101181954, DT.101377392, DT.55107305, DT.94376167
NIA Mouse Gene Index	U037974
Consensus CDS Project	CCDS37670.1
International Mouse Knockout Project Status	C3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000042133	VEGA Gene Model | MGI Sequence Detail	24167	C57BL/6J
transcript	OTTMUST00000110561	VEGA | MGI Sequence Detail	5136	Not Applicable
polypeptide	OTTMUSP00000061702	VEGA | MGI Sequence Detail	1663	Not Applicable

All sequences(46) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(7) : SNPs(82 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001599	Alpha-2-macroglobulin
InterPro	IPR019742	Alpha-2-macroglobulin, conserved site
InterPro	IPR002890	Alpha-2-macroglobulin, N-terminal
InterPro	IPR011625	Alpha-2-macroglobulin, N-terminal 2
InterPro	IPR019565	Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro	IPR009048	Alpha-macroglobulin, receptor-binding
InterPro	IPR011626	A-macroglobulin complement component
InterPro	IPR018081	Anaphylatoxin
InterPro	IPR000020	Anaphylatoxin/fibulin
InterPro	IPR001840	Complement C3a/C4a/C5a anaphylatoxin
InterPro	IPR001134	Netrin domain
InterPro	IPR018933	Netrin module, non-TIMP type
InterPro	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
InterPro	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology	PR:000004900	complement C3

References

(Earliest) J:5960 Da Silva FP, et al., Murine complement component 3: genetic variation and linkage to H-2. Proc Natl Acad Sci U S A. 1978 Feb;75(2):963-5
(Latest) J:195307 Sponarova J, et al., Efficient amyloid a clearance in the absence of immunoglobulins and complement factors. Am J Pathol. 2013 Apr;182(4):1297-307
All references(355)

Other accession IDs

MGD-MRK-1700, MGI:2146809