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Phenotypes Associated with This Genotype
Genotype
MGI:2449063
Allelic
Composition		 C3tm1Hrc/C3tm1Hrc
Genetic
Background		 either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Hrc mutation (2 available); any C3 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:56193 )
• a 2000-fold increase in pneumococci is seen compared to wild-type littermates following infection with S. pneumoniae

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
complement component 3 deficiency DOID:8354 OMIM:613779
 J:56193

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory