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Bdnf
Gene Detail
Symbol

Name
ID
Bdnf
brain derived neurotrophic factor
MGI:88145
Feature Type
protein coding gene
Genetic Map
Chromosome 2
56.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:109674700-109727007 bp, + strand
From VEGA annotation of GRCm38

  52308 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7245  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: nerve growth factor, subunit beta
Gene Tree: Bdnf

Human
homologs
Human Homolog BDNF, brain-derived neurotrophic factor
NCBI Gene ID 627
neXtProt AC  NX_P23560
Human Synonyms  ANON2, BULN2
Human Chr (Location)  11p13; chr11:27654893-27722058 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human BDNF
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(3) Targeted(24)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null alleles exhibit sensory neuron losses affecting coordination, balance, hearing, taste, and breathing, cerebellar abnormalities, increased sympathetic neuron number, and postnatal lethality. Carriers show mild defects.
 
Human Diseases Modeled Using Mouse Bdnf (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Bdnf interacts with 383 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process axon extension, axon guidance, ...
Component axon, cell, ...
Function growth factor activity, neurotrophin TRKB receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (82 records)
Data Summary: Results (262)    Tissues (154)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 226
Northern blot 4
RT-PCR 29
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(3) cDNA(13) Primer pair(5) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000015122 (Evidence)
Ensembl Gene ModelENSMUSG00000048482 (Evidence)
Entrez Gene12064 (Evidence)
UniGene1442
DFCITC1586803, TC1608965, TC1671304
DoTSDT.101345200, DT.101357751, DT.110686956, DT.40168441, DT.486320, DT.97412972, DT.97412973, DT.97412975, DT.97412976
NIA Mouse Gene IndexU002219
Consensus CDS ProjectCCDS38193.1, CCDS38194.1
International Mouse Knockout Project StatusBdnf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015122 VEGA Gene Model | MGI Sequence Detail 52308 C57BL/6J ±  kb
transcript OTTMUST00000101214 VEGA | MGI Sequence Detail 3905 Not Applicable 
polypeptide OTTMUSP00000056674 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(118) RefSeq(22) UniProt(11)
Polymorphisms
SNPs within 2kb(237 from dbSNP Build 137)    SNPs within 2kb including multiple locations(239)
Protein-related
information
ResourceIDDescription
InterPro IPR020430 Brain-derived neurotrophic factor
InterPro IPR019846 Nerve growth factor conserved site
InterPro IPR020408 Nerve growth factor-like
InterPro IPR002072 Nerve growth factor-related
Protein Ontology PR:000004716 brain-derived neurotrophic factor
References
(Earliest) J:14600 Barde YA, et al., Purification of a new neurotrophic factor from mammalian brain. EMBO J. 1982;1(5):549-53
(Latest) J:214739 Glerup S, et al., SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. 2014 Jun 4;82(5):1074-87
All references(474)
Other
accession IDs
MGD-MRK-1534

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory