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Bdnf Gene Detail
Summary
  • Symbol
    Bdnf
  • Name
    brain derived neurotrophic factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:88145
    NCBI Gene: 12064
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:109674700-109727007 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 56.63 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    234 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88145
protein coding gene Chr2:109674700-109727043 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026240
protein coding gene Chr2:112013777-112067064 (+)
A/J MGP_AJ_G0026201
protein coding gene Chr2:107324885-107377558 (+)
AKR/J MGP_AKRJ_G0026181
protein coding gene Chr2:110340165-110392410 (+)
BALB/cJ MGP_BALBcJ_G0026210
protein coding gene Chr2:107597053-107649357 (+)
C3H/HeJ MGP_C3HHeJ_G0025960
protein coding gene Chr2:110629214-110682570 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026661
protein coding gene Chr2:115669430-115721724 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024047
protein coding gene Chr2:102886110-102938070 (+)
CAST/EiJ MGP_CASTEiJ_G0025425
protein coding gene Chr2:111130755-111184804 (+)
CBA/J MGP_CBAJ_G0025938
protein coding gene Chr2:119682136-119733922 (+)
DBA/2J MGP_DBA2J_G0026076
protein coding gene Chr2:106827382-106879729 (+)
FVB/NJ MGP_FVBNJ_G0026039
protein coding gene Chr2:105743340-105808154 (+)
LP/J MGP_LPJ_G0026179
protein coding gene Chr2:112197197-112250630 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026063
protein coding gene Chr2:123799629-123855706 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026715
protein coding gene Chr2:110489322-110542512 (+)
PWK/PhJ MGP_PWKPhJ_G0025160
protein coding gene Chr2:106463432-106516119 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024960
protein coding gene Chr2:109711491-109766141 (+)
WSB/EiJ MGP_WSBEiJ_G0025492
protein coding gene Chr2:111244220-111298109 (+)



Homology
more
  • Human Ortholog
    BDNF, brain derived neurotrophic factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BDNF, brain derived neurotrophic factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ANON2, BULN2
  • Links
    NCBI Gene ID: 627
    neXtProt AC: NX_P23560
    UniProt: P23560

  • Chr Location
    11p14.1; chr11:27654893-27722058 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    151 phenotypes from 21 alleles in 28 genetic backgrounds
    45 phenotypes from multigenic genotypes
    361 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null alleles exhibit sensory neuron losses affecting coordination, balance, hearing, taste, and breathing, cerebellar abnormalities, increased sympathetic neuron number, and postnatal lethality. Carriers show mild defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048482 Ensembl Gene Model | MGI Sequence Detail 52308 C57BL/6J ±  kb
    transcript ENSMUST00000111042 Ensembl | MGI Sequence Detail 3905 Not Applicable  
    polypeptide ENSMUSP00000106671 Ensembl | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 3
      cDNA 14
      Primer pair 6
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1534
    References
    more
    • Summaries
      All 659
      Developmental Gene Expression 96
      Diseases 2
      Gene Ontology 38
      Phenotypes 361
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:264523 Colgan LA, et al., PKCalpha integrates spatiotemporally distinct Ca(2+) and autocrine BDNF signaling to facilitate synaptic plasticity. Nat Neurosci. 2018 Aug;21(8):1027-1037

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory