Bdnf
Gene Detail

Symbol Name ID

Bdnf brain derived neurotrophic factor MGI:88145

Feature Type

protein coding gene

Genetic Map

Chromosome 2

56.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr2:109674700-109727007 bp, + strand From VEGA annotation of GRCm38   52308 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7245  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: nerve growth factor, subunit beta
Gene Tree: Bdnf

Human homologs

Human Homolog		BDNF, brain-derived neurotrophic factor
NCBI Gene ID		627
neXtProt AC		NX_P23560
Human Synonyms		ANON2, BULN2
Human Chr (Location)		11p13; chr11:27676440-27743605 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human BDNF

Alleles and phenotypes

All alleles(27) : Targeted(24) Gene trapped(3)
 

Homozygotes for targeted null alleles exhibit sensory neuron losses affecting coordination, balance, hearing, taste, and breathing, cerebellar abnormalities, increased sympathetic neuron number, and postnatal lethality. Carriers show mild defects.

 
Human Diseases Modeled Using Mouse Bdnf (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	axon guidance, axon target recognition, ...
Component	cytoplasmic membrane-bounded vesicle, extracellular region, ...
Function	growth factor activity, neurotrophin TRKB receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (76 records)
Data Summary: Results (262)    Tissues (152)    Images (39)
Theiler Stages: 17, 19, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	226
Northern blot	4
RT-PCR	29

cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(3) cDNA(15) Primer pair(5) Other(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000015122 (Evidence)
Ensembl Gene Model	ENSMUSG00000048482 (Evidence)
Entrez Gene	12064 (Evidence)
UniGene	1442
DFCI	TC1586803, TC1608965, TC1671304
DoTS	DT.101345200, DT.101357751, DT.110686956, DT.40168441, DT.486320, DT.97412972, DT.97412973, DT.97412975, DT.97412976
NIA Mouse Gene Index	U002219
Consensus CDS Project	CCDS38193.1, CCDS38194.1
International Mouse Knockout Project Status	Bdnf

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015122	VEGA Gene Model | MGI Sequence Detail	52308	C57BL/6J
transcript	OTTMUST00000101214	VEGA | MGI Sequence Detail	3905	Not Applicable
polypeptide	OTTMUSP00000056674	VEGA | MGI Sequence Detail	289	Not Applicable

All sequences(99) RefSeq(8) UniProt(6)

Polymorphisms

SNPs(201 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020430	Brain-derived neurotrophic factor
InterPro	IPR019846	Nerve growth factor conserved site
InterPro	IPR020408	Nerve growth factor-like
InterPro	IPR002072	Nerve growth factor-related
Protein Ontology	PR:000004716	brain-derived neurotrophic factor

References

(Earliest) J:14600 Barde YA, et al., Purification of a new neurotrophic factor from mammalian brain. EMBO J. 1982;1(5):549-53
(Latest) J:193539 Fox EA, et al., Mechanism of hyperphagia contributing to obesity in brain-derived neurotrophic factor knockout mice. Neuroscience. 2013 Jan 15;229:176-99
All references(435)

Other accession IDs

MGD-MRK-1534