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Araf
Gene Detail
Symbol

Name
ID
Araf
v-raf murine sarcoma 3611 viral oncogene homolog
MGI:88065
Synonyms
1200013E08Rik, A-Raf, Araf1
Feature Type
protein coding gene
Genetic Map
Chromosome X
16.30 cM, cytoband A2-A3.1
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
ChrX:20797814-20860519 bp, + strand
From VEGA annotation of GRCm38

  62706 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: ARAF
Protein SuperFamily: RAF proto-oncogene serine/threonine-protein kinase
Gene Tree: Araf

Human
homologs
ARAF, A-Raf proto-oncogene, serine/threonine kinase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 369
neXtProt AC: NX_P10398

Human Synonyms: A-RAF, ARAF1, PKS2, RAFA1

Human Chr (Location): Xp11.4-p11.2; chrX:47561100-47571921 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(29) Targeted(2)
 
Homozygous females or hemizygous males for a null targeted mutation show variable genetic background effects, from preweaning death, wasting, tremors, distended colon and small thymus to normal survival and breeding with mild neurological defects.
 
Interactions
Araf interacts with 246 markers (Mir1a-1, Mir1a-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process activation of MAPKK activity, intracellular signal transduction, ...
Component cytosol, mitochondrion
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (109)    Tissues (73)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 40
Northern blot 62
RT-PCR 7
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100495479    NEW 
Molecular
reagents
All nucleic(31) Genomic(2) cDNA(26) Primer pair(1) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000017167 (Evidence)
Ensembl Gene Model ENSMUSG00000001127 (Evidence)
Entrez Gene 11836 (Evidence)
DFCI TC1573034, TC1580012, TC1588119, TC1659229, TC1730717
DoTS DT.101733749, DT.101735005, DT.111029646, DT.40183228, DT.55224006, DT.87054640, DT.91334583, DT.94190495, DT.97377492
NIA Mouse Gene Index U019753
EC 2.7.11.1
Consensus CDS Project CCDS40886.1, CCDS53016.1
International Mouse Phenotyping Consortium Status Araf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017167 VEGA Gene Model | MGI Sequence Detail 62706 C57BL/6J ±  kb
transcript OTTMUST00000041570 VEGA | MGI Sequence Detail 2358 Not Applicable 
polypeptide OTTMUSP00000018673 VEGA | MGI Sequence Detail 604 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(12) UniProt(8)
Polymorphisms
RFLP(5) : SNPs within 2kb(139 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR003116 Raf-like Ras-binding
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR029071 Ubiquitin-related domain
Protein Ontology PR:000004192 serine/threonine-protein kinase A-Raf
References
(Earliest) J:8306 Huebner K, et al., Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3934-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(64)
Other
accession IDs
MGD-MRK-1385, MGI:1914126, MGI:2148014

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory