Fscn2
Gene Detail

Symbol Name ID

Fscn2 fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) MGI:2443337

Synonyms

ahl8, C630046B20Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

84.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:120361534-120368168 bp, + strand From VEGA annotation of GRCm38   6635 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22722  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: Fascin
Gene Tree: Fscn2

Human homologs

Human Homolog		FSCN2, Fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
NCBI Gene ID		25794
neXtProt AC		NX_O14926
Human Synonyms		RFSN, RP30
Human Chr (Location)		17q25; chr17:79495417-79504156 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FSCN2

Alleles and phenotypes

All alleles(9) : Targeted(5) Gene trapped(3) Spontaneous(1)
 

Mice homozygous for disruptions in this gene display retinal generation with structural abnormalities of the outer segment and depressed rod and cone ERGs that worsen with age.

 
Human Diseases Modeled Using Mouse Fscn2 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	eye photoreceptor cell development
Component	actin cytoskeleton, cell projection, ...
Function	actin binding, actin filament binding, ...

External Resources: FuncBase

Expression

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(7)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000004147 (Evidence)
Ensembl Gene Model	ENSMUSG00000025380 (Evidence)
Entrez Gene	238021 (Evidence)
UniGene	481403
DFCI	TC1588378, TC1595227
DoTS	DT.101723683, DT.91396071, DT.94278749
NIA Mouse Gene Index	U013657
Consensus CDS Project	CCDS25731.1
International Mouse Knockout Project Status	Fscn2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004147	VEGA Gene Model | MGI Sequence Detail	6635	C57BL/6J
transcript	OTTMUST00000009385	VEGA | MGI Sequence Detail	1713	Not Applicable
polypeptide	OTTMUSP00000004566	VEGA | MGI Sequence Detail	492	Not Applicable

All sequences(26) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(40 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008999	Actin cross-linking
InterPro	IPR024703	Fascin
InterPro	IPR022768	Fascin domain
Protein Ontology	PR:000007678	fascin-2

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)

Other accession IDs

MGI:3575429