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Fscn2
Gene Detail
 Symbol
Name
ID
Fscn2
fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
MGI:2443337
Synonyms ahl8, C630046B20Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
84.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:120361534-120368168 bp, + strand
From VEGA annotation of GRCm38

  6635 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22722  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: Fascin
Gene Tree: Fscn2

Human
homologs
Human Homolog FSCN2, fascin actin-bundling protein 2, retinal
NCBI Gene ID 25794
neXtProt AC  NX_O14926
Human Synonyms  RFSN, RP30
Human Chr (Location)  17q25; chr17:81513995-81537130 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FSCN2
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(3) Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display retinal generation with structural abnormalities of the outer segment and depressed rod and cone ERGs that worsen with age.
 
Human Diseases Modeled Using Mouse Fscn2 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Fscn2 interacts with 12 markers (Mir141, Mir155, Mir327, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process actin filament organization, eye photoreceptor cell development
Component actin cytoskeleton, cell projection, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000004147 (Evidence)
Ensembl Gene ModelENSMUSG00000025380 (Evidence)
Entrez Gene238021 (Evidence)
UniGene481403
DFCITC1588378, TC1595227
DoTSDT.101723683, DT.91396071, DT.94278749
NIA Mouse Gene IndexU013657
Consensus CDS ProjectCCDS25731.1
International Mouse Knockout Project StatusFscn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004147 VEGA Gene Model | MGI Sequence Detail 6635 C57BL/6J ±  kb
transcript OTTMUST00000009385 VEGA | MGI Sequence Detail 1713 Not Applicable 
polypeptide OTTMUSP00000004566 VEGA | MGI Sequence Detail 492 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008999 Actin cross-linking
InterPro IPR010431 Fascin
InterPro IPR022768 Fascin domain
InterPro IPR024703 Fascin, metazoans
Protein Ontology PR:000007678 fascin-2
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:197137 Perrin BJ, et al., beta-Actin and Fascin-2 Cooperate to Maintain Stereocilia Length. J Neurosci. 2013 May 8;33(19):8114-21
All references(32)
Disease annotation references (1)
Other
accession IDs
MGI:3575429

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory