About   Help   FAQ
Fscn2 Gene Detail
Summary
  • Symbol
    Fscn2
  • Name
    fascin actin-bundling protein 2
  • Synonyms
    ahl8, C630046B20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443337
    NCBI Gene: 238021
  • Gene Overview
    MyGene.info: FSCN2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:120361534-120368168 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6635 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 84.08 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FSCN2, fascin actin-bundling protein 2, retinal
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FSCN2, fascin actin-bundling protein 2, retinal
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RFSN, RP30
  • Links
    NCBI Gene ID: 25794
    neXtProt AC: NX_O14926
    UniProt: O14926

  • Chr Location
    17q25.3; chr17:81513019-81537130 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 22722
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FSCN2
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Fscn2 mouse models; 1 with human FSCN2 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 4 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display retinal generation with structural abnormalities of the outer segment and depressed rod and cone ERGs that worsen with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000004147 VEGA Gene Model | MGI Sequence Detail 6635 C57BL/6J ±  kb
    transcript OTTMUST00000009385 VEGA | MGI Sequence Detail 1713 Not Applicable  
    polypeptide OTTMUSP00000004566 VEGA | MGI Sequence Detail 492 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      44 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:3575429
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:242628 Krey JF, et al., Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid. J Cell Biol. 2016 Nov 21;215(4):467-482

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory