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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fscn2
fascin actin-bundling protein 2
MGI:2443337
30 phenotypes from 4 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fscn2ahl8/Fscn2ahl8
DBA/2J 		abnormal auditory brainstem response J:139223
decreased inner hair cell stereocilia number J:162868
decreased outer hair cell stereocilia number J:162868
increased or absent threshold for auditory brainstem response J:162868
increased susceptibility to age-related hearing loss J:139223, J:162868
Fscn2em1Fhan/Fscn2em1Fhan
C57BL/6J-Fscn2em1Fhan 		abnormal cochlear hair cell stereociliary bundle morphology J:274170
abnormal cochlear outer hair cell physiology J:274170
abnormal photoreceptor inner segment morphology J:274170
abnormal photoreceptor outer segment size J:274170
abnormal vision J:274170
cochlear outer hair cell degeneration J:274170
decreased a-wave amplitude J:274170
decreased b-wave amplitude J:274170
decreased distortion product otoacoustic emission amplitude J:274170
decreased total retina thickness J:274170
impaired hearing J:274170
increased or absent threshold for auditory brainstem response J:274170
photoreceptor inner segment degeneration J:274170
photoreceptor outer segment degeneration J:274170
retina degeneration J:274170
retina outer nuclear layer degeneration J:274170
short cochlear hair cell stereocilia J:274170
thin retina outer nuclear layer J:274170
Fscn2tm1Sykk/Fscn2+
involves: 129S4/SvJae * C57BL/6 		abnormal cone electrophysiology J:103713
abnormal eye electrophysiology J:103713
abnormal retina morphology J:103713
abnormal rod electrophysiology J:103713
increased susceptibility to age-related retinal degeneration J:103713
short photoreceptor outer segment J:103713
thin retina inner nuclear layer J:103713
thin retina outer nuclear layer J:103713
Fscn2tm1Sykk/Fscn2tm1Sykk
involves: 129S4/SvJae * C57BL/6 		abnormal cone electrophysiology J:103713
abnormal eye electrophysiology J:103713
abnormal retina morphology J:103713
abnormal rod electrophysiology J:103713
increased susceptibility to age-related retinal degeneration J:103713
short photoreceptor outer segment J:103713
thin retina inner nuclear layer J:103713
thin retina outer nuclear layer J:103713
Fscn2tm2Sykk/Fscn2+
involves: 129S4/SvJae * C57BL/6 		abnormal cone electrophysiology J:103713
abnormal eye electrophysiology J:103713
abnormal retina morphology J:103713
abnormal rod electrophysiology J:103713
increased susceptibility to age-related retinal degeneration J:103713
short photoreceptor outer segment J:103713
thin retina inner nuclear layer J:103713
thin retina outer nuclear layer J:103713
Fscn2tm2Sykk/Fscn2tm2Sykk
involves: 129S4/SvJae * C57BL/6 		abnormal cone electrophysiology J:103713
abnormal eye electrophysiology J:103713
abnormal photoreceptor outer segment morphology J:103713
abnormal retina morphology J:103713
abnormal rod electrophysiology J:103713
increased susceptibility to age-related retinal degeneration J:103713
short photoreceptor outer segment J:103713
thin retina inner nuclear layer J:103713
thin retina outer nuclear layer J:103713
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory