Fscn2^em1Fhan
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fscn2^em1Fhan
• Name: fascin actin-bundling protein 2; endonuclease-mediated mutation 1, Fengchan Han
• MGI ID: MGI:6386115
• Gene: Fscn2 Location: Chr11:120252360-120258994 bp, + strand Genetic Position: Chr11, 84.08 cM
• Alliance: Fscn2^em1Fhan page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN methodology generated a 41-bp deletion in exon 1. This deletion was expected to produce a truncated peptide with 36 amino acid residues. However, Western blot analysis showed no protein in cochlea or the retina. (J:274170)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fscn2 Mutation: 37 strains or lines available

References

• Original: J:274170 Liu X, et al., Null Mutation of the Fascin2 Gene by TALEN Leading to Progressive Hearing Loss and Retinal Degeneration in C57BL/6J Mice. G3 (Bethesda). 2018 Oct 3;8(10):3221-3230
• All: 2 reference(s)