About   Help   FAQ
Arid5a Gene Detail
Summary
  • Symbol
    Arid5a
  • Name
    AT rich interactive domain 5A (MRF1-like)
  • Synonyms
    D430024K22Rik, Mrf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443039
    NCBI Gene: 214855
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:36307733-36324029 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16297 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 15.20 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ARID5A, AT-rich interaction domain 5A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ARID5A, AT-rich interaction domain 5A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MRF1, MRF-1, RP11-363D14
  • Links
    NCBI Gene ID: 10865
    neXtProt AC: NX_Q03989
    UniProt: Q03989

  • Chr Location
    2q11.2; chr2:96536719-96552638 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced serum interleukin-6 and tumor necrosis factor levels following LPS treatment, and decreased susceptibility to experimental autoimmune encephalomyelitis along with decreased T-helper 17 cell number and increased IFN-gamma producing T cell number.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021515 VEGA Gene Model | MGI Sequence Detail 16297 C57BL/6J ±  kb
    transcript OTTMUST00000051017 VEGA | MGI Sequence Detail 3002 Not Applicable  
    polypeptide OTTMUSP00000023951 VEGA | MGI Sequence Detail 684 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      111 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 58
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:246343 Dubey PK, et al., Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury. Int Immunol. 2017 Feb 01;29(2):79-85

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory