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Mfn2
Gene Detail
Symbol

Name
ID
Mfn2
mitofusin 2
MGI:2442230
Synonyms
D630023P19Rik, Fzo, hypertension related protein 1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
78.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:147873599-147904704 bp, - strand
From VEGA annotation of GRCm38

  31106 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8915  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MFN2
Gene Tree: Mfn2

Human
homologs
MFN2, mitofusin 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9927
neXtProt AC: NX_O95140

Human Synonyms: CMT2A, CMT2A2, CPRP1, HSG, MARF

Human Chr (Location): 1p36.22; chr1:11980181-12013515 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human MFN2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(2) Targeted(9) Transgenic(2)
Genomic Mutations involving Mfn2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die in mid-gestation. Structural and functional abnormalities of mitochondria are reported.
 
Mutations Annotated to Human Diseases (3)    Phenotype Images(5)
Interactions
Mfn2 interacts with 229 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process apoptotic process, autophagy, ...
Component cytosol, integral component of membrane, ...
Function GTPase activity, GTPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (33)    Tissues (15)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
Western blot 13
RT-PCR 13
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase mfn2 ; ZFIN mfn2    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000010659 (Evidence)
Ensembl Gene Model ENSMUSG00000029020 (Evidence)
Entrez Gene 170731 (Evidence)
DFCI TC1698279, TC1695428, TC1591606, TC1679780, TC1571897
DoTS DT.101382049, DT.533632, DT.101382048, DT.101382046, DT.110811295, DT.91397514, DT.99863381, DT.91294542
NIA Mouse Gene Index U025777
EC 3.6.5.-
Consensus CDS Project CCDS38965.1
International Mouse Phenotyping Consortium Status Mfn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010659 VEGA Gene Model | MGI Sequence Detail 31106 C57BL/6J ±  kb
transcript OTTMUST00000024883 VEGA | MGI Sequence Detail 4241 Not Applicable 
polypeptide OTTMUSP00000011416 VEGA | MGI Sequence Detail 757 Not Applicable 

For the selected sequences
All sequences(110) RefSeq(30) UniProt(5)
Polymorphisms
SNPs within 2kb(211 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006884 Fzo/mitofusin HR2 domain
InterPro IPR027089 Mitofusin-2
InterPro IPR027094 Mitofusin family
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010370 mitofusin-2
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:219969 Song M, et al., Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab. 2015 Feb 3;21(2):273-85
All references(79)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory