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Mfn2
Gene Detail
 Symbol
Name
ID
Mfn2
mitofusin 2
MGI:2442230
Synonyms D630023P19Rik, Fzo, hypertension related protein 1
Feature Type protein coding gene
Genetic Map
Chromosome 4
78.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:147873599-147904704 bp, - strand
From VEGA annotation of GRCm38

  31106 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8915  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mfn2

Human
homologs
Human Homolog MFN2, mitofusin 2
NCBI Gene ID 9927
neXtProt AC  NX_O95140
Human Synonyms  CMT2A, CMT2A2, CPRP1, HSG, MARF
Human Chr (Location)  1p36.22; chr1:11980181-12013515 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human MFN2
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die in mid-gestation. Structural and functional abnormalities of mitochondria are reported.
 
Human Diseases Modeled Using Mouse Mfn2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Mfn2 interacts with 229 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process blastocyst formation, camera-type eye morphogenesis, ...
Component cytosol, integral component of membrane, ...
Function GTPase activity, GTPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (33)    Tissues (15)    Images (3)
Theiler Stages: 1, 2, 3, 4, 5, 17, 20, 22, 26, 27, 28
Assay TypeResults
Immunohistochemistry 7
Western blot 13
RT-PCR 13
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000010659 (Evidence)
Ensembl Gene ModelENSMUSG00000029020 (Evidence)
Entrez Gene170731 (Evidence)
DFCITC1571897, TC1591606, TC1679780, TC1695428, TC1698279
DoTSDT.101382046, DT.101382048, DT.101382049, DT.110811295, DT.533632, DT.91294542, DT.91397514, DT.99863381
NIA Mouse Gene IndexU025777
EC3.6.5.-
Consensus CDS ProjectCCDS38965.1
International Mouse Knockout Project StatusMfn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010659 VEGA Gene Model | MGI Sequence Detail 31106 C57BL/6J ±  kb
transcript OTTMUST00000024883 VEGA | MGI Sequence Detail 4241 Not Applicable 
polypeptide OTTMUSP00000011416 VEGA | MGI Sequence Detail 757 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(30) UniProt(5)
Polymorphisms SNPs within 2kb(211 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001401 Dynamin, GTPase domain
InterPro IPR006884 Fzo/mitofusin HR2 domain
InterPro IPR027089 Mitofusin-2
InterPro IPR027094 Mitofusin family
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010370 mitofusin-2
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:211366 Yue W, et al., A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Cell Res. 2014 Apr;24(4):482-96
All references(76)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory